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Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases.
Mol Neurobiol. 2015; 51(3):1249-62.MN

Abstract

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), originate from a loss of neurons in the central nervous system (CNS) and are severely debilitating. The incidence of neurodegenerative diseases increases with age, and they are expected to become more common due to extended life expectancy. Because of no clear mechanisms, these diseases have become a major challenge in neurobiology. It is well recognized that these disorders become the culmination of many different genetic and environmental influences. Prior studies have shown that microRNAs (miRNAs) are pathologically altered during the inexorable course of some neurodegenerative diseases, suggesting that miRNAs may be the contributing factor in neurodegeneration. Here, we review what is known about the involvement of miRNAs in the pathogenesis of neurodegenerative diseases. The biogenesis of miRNAs and various functions of miRNAs that act as the chief regulators will be discussed. We focus in particular on dysregulation of miRNAs which leads to several neurodegenerative diseases from three aspects: miRNA-generating disorders, miRNA-targeting genes and epigenetic alterations. Furthermore, recent evidences have shown that circulating miRNA expression levels are changed in patients with neurodegenerative diseases. Circulating miRNA expression levels are reported in patients in order to evaluate their application as biomarkers of these diseases. A discussion is included with a potential diagnostic biomarker and the possible future direction in exploring the nexus between miRNAs and various neurodegenerative diseases.

Authors+Show Affiliations

College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24973986

Citation

Tan, Lin, et al. "Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases." Molecular Neurobiology, vol. 51, no. 3, 2015, pp. 1249-62.
Tan L, Yu JT, Tan L. Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases. Mol Neurobiol. 2015;51(3):1249-62.
Tan, L., Yu, J. T., & Tan, L. (2015). Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases. Molecular Neurobiology, 51(3), 1249-62. https://doi.org/10.1007/s12035-014-8803-9
Tan L, Yu JT, Tan L. Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases. Mol Neurobiol. 2015;51(3):1249-62. PubMed PMID: 24973986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases. AU - Tan,Lin, AU - Yu,Jin-Tai, AU - Tan,Lan, Y1 - 2014/06/29/ PY - 2014/05/13/received PY - 2014/06/22/accepted PY - 2014/6/30/entrez PY - 2014/6/30/pubmed PY - 2016/3/11/medline SP - 1249 EP - 62 JF - Molecular neurobiology JO - Mol Neurobiol VL - 51 IS - 3 N2 - Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), originate from a loss of neurons in the central nervous system (CNS) and are severely debilitating. The incidence of neurodegenerative diseases increases with age, and they are expected to become more common due to extended life expectancy. Because of no clear mechanisms, these diseases have become a major challenge in neurobiology. It is well recognized that these disorders become the culmination of many different genetic and environmental influences. Prior studies have shown that microRNAs (miRNAs) are pathologically altered during the inexorable course of some neurodegenerative diseases, suggesting that miRNAs may be the contributing factor in neurodegeneration. Here, we review what is known about the involvement of miRNAs in the pathogenesis of neurodegenerative diseases. The biogenesis of miRNAs and various functions of miRNAs that act as the chief regulators will be discussed. We focus in particular on dysregulation of miRNAs which leads to several neurodegenerative diseases from three aspects: miRNA-generating disorders, miRNA-targeting genes and epigenetic alterations. Furthermore, recent evidences have shown that circulating miRNA expression levels are changed in patients with neurodegenerative diseases. Circulating miRNA expression levels are reported in patients in order to evaluate their application as biomarkers of these diseases. A discussion is included with a potential diagnostic biomarker and the possible future direction in exploring the nexus between miRNAs and various neurodegenerative diseases. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/24973986/Causes_and_Consequences_of_MicroRNA_Dysregulation_in_Neurodegenerative_Diseases_ L2 - https://dx.doi.org/10.1007/s12035-014-8803-9 DB - PRIME DP - Unbound Medicine ER -