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Antimicrobial susceptibility patterns of Burkholderia pseudomallei among melioidosis cases in Kedah, Malaysia.

Abstract

Burkholderia pseudomallei, the causative agent of melioidosis is an important cause of morbidity and mortality particularly among diabetics. We evaluated 228 isolates of B. pseudomallei for antimicrobial sensitivity during 2005-2010 using the disc diffusion technique, of which 144 were obtained from blood culture. More than 90% of the strains were susceptible to cefoperazone, ceftazidime, chloramphenicol and imipenem. Eighty-two percent of the isolates were susceptible to tetracycline and amoxicillin/clavulanate. The susceptibilities to ciprofloxacin was 78% and to trimethoprim-sulfamethoxezole was 47%. The susceptibilities to aminoglycoside antibiotics were low (21% to gentamicin and 6% to amikacin). The susceptibilities were similar between isolates from females and males, bacteremic and abacteremic cases, diabetics and non-diabetics, pneumonia and non-pneumonia cases and between those who died and those who survived. Our findings show antibiotic susceptibility patterns are not a major factor in determining outcomes of B. pseudomallei infection. Monitoring the drug susceptibilities among B. pseudomallei isolates needs to be conducted regularly to guide empiric therapy for melioidosis, as it causes high mortality, especially among diabetic cases.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24974653

Citation

Hassan, Muhammad R A., et al. "Antimicrobial Susceptibility Patterns of Burkholderia Pseudomallei Among Melioidosis Cases in Kedah, Malaysia." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 45, no. 3, 2014, pp. 680-8.
Hassan MR, Vijayalakshmi N, Pani SP, et al. Antimicrobial susceptibility patterns of Burkholderia pseudomallei among melioidosis cases in Kedah, Malaysia. Southeast Asian J Trop Med Public Health. 2014;45(3):680-8.
Hassan, M. R., Vijayalakshmi, N., Pani, S. P., Peng, N. P., Mehenderkar, R., Voralu, K., & Michael, E. (2014). Antimicrobial susceptibility patterns of Burkholderia pseudomallei among melioidosis cases in Kedah, Malaysia. The Southeast Asian Journal of Tropical Medicine and Public Health, 45(3), 680-8.
Hassan MR, et al. Antimicrobial Susceptibility Patterns of Burkholderia Pseudomallei Among Melioidosis Cases in Kedah, Malaysia. Southeast Asian J Trop Med Public Health. 2014;45(3):680-8. PubMed PMID: 24974653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial susceptibility patterns of Burkholderia pseudomallei among melioidosis cases in Kedah, Malaysia. AU - Hassan,Muhammad R A, AU - Vijayalakshmi,Natesan, AU - Pani,Subhada Prasad, AU - Peng,Ng P, AU - Mehenderkar,Ranjith, AU - Voralu,Kirtanaa, AU - Michael,Edwin, PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2014/7/22/medline SP - 680 EP - 8 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 45 IS - 3 N2 - Burkholderia pseudomallei, the causative agent of melioidosis is an important cause of morbidity and mortality particularly among diabetics. We evaluated 228 isolates of B. pseudomallei for antimicrobial sensitivity during 2005-2010 using the disc diffusion technique, of which 144 were obtained from blood culture. More than 90% of the strains were susceptible to cefoperazone, ceftazidime, chloramphenicol and imipenem. Eighty-two percent of the isolates were susceptible to tetracycline and amoxicillin/clavulanate. The susceptibilities to ciprofloxacin was 78% and to trimethoprim-sulfamethoxezole was 47%. The susceptibilities to aminoglycoside antibiotics were low (21% to gentamicin and 6% to amikacin). The susceptibilities were similar between isolates from females and males, bacteremic and abacteremic cases, diabetics and non-diabetics, pneumonia and non-pneumonia cases and between those who died and those who survived. Our findings show antibiotic susceptibility patterns are not a major factor in determining outcomes of B. pseudomallei infection. Monitoring the drug susceptibilities among B. pseudomallei isolates needs to be conducted regularly to guide empiric therapy for melioidosis, as it causes high mortality, especially among diabetic cases. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/24974653/Antimicrobial_susceptibility_patterns_of_Burkholderia_pseudomallei_among_melioidosis_cases_in_Kedah_Malaysia_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -