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Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review.
Exerc Immunol Rev. 2014; 20:94-116.EI

Abstract

An increasing number of studies have examined how the immune system of patients with Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis, responds to exercise. The objective of the present study was to systematically review the scientific literature addressing exercise-induced immunological changes in CFS patients compared to healthy control subjects. A systematic literature search was conducted in the PubMed and Web of science databases using different keyword combinations. We included 23 case control studies that examined whether CFS patients, compared to healthy sedentary controls, have a different immune response to exercise. The included articles were evaluated on their methodological quality. Compared to the normal response of the immune system to exercise as seen in healthy subjects, patients with CFS have a more pronounced response in the complement system (i.e. C4a split product levels), oxidative stress system (i.e. enhanced oxidative stress combined with a delayed and reduced anti-oxidant response), and an alteration in the immune cells' gene expression profile (increases in post-exercise interleukin-10 and toll-like receptor 4 gene expression), but not in circulating pro- or anti-inflammatory cytokines. Many of these immune changes relate to post-exertional malaise in CFS, a major characteristic of the illness. The literature review provides level B evidence for an altered immune response to exercise in patients with CFS.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24974723

Citation

Nijs, Jo, et al. "Altered Immune Response to Exercise in Patients With Chronic Fatigue Syndrome/myalgic Encephalomyelitis: a Systematic Literature Review." Exercise Immunology Review, vol. 20, 2014, pp. 94-116.
Nijs J, Nees A, Paul L, et al. Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. Exerc Immunol Rev. 2014;20:94-116.
Nijs, J., Nees, A., Paul, L., De Kooning, M., Ickmans, K., Meeus, M., & Van Oosterwijck, J. (2014). Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. Exercise Immunology Review, 20, 94-116.
Nijs J, et al. Altered Immune Response to Exercise in Patients With Chronic Fatigue Syndrome/myalgic Encephalomyelitis: a Systematic Literature Review. Exerc Immunol Rev. 2014;20:94-116. PubMed PMID: 24974723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. AU - Nijs,Jo, AU - Nees,Andrea, AU - Paul,Lorna, AU - De Kooning,Margot, AU - Ickmans,Kelly, AU - Meeus,Mira, AU - Van Oosterwijck,Jessica, PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2014/7/18/medline SP - 94 EP - 116 JF - Exercise immunology review JO - Exerc Immunol Rev VL - 20 N2 - An increasing number of studies have examined how the immune system of patients with Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis, responds to exercise. The objective of the present study was to systematically review the scientific literature addressing exercise-induced immunological changes in CFS patients compared to healthy control subjects. A systematic literature search was conducted in the PubMed and Web of science databases using different keyword combinations. We included 23 case control studies that examined whether CFS patients, compared to healthy sedentary controls, have a different immune response to exercise. The included articles were evaluated on their methodological quality. Compared to the normal response of the immune system to exercise as seen in healthy subjects, patients with CFS have a more pronounced response in the complement system (i.e. C4a split product levels), oxidative stress system (i.e. enhanced oxidative stress combined with a delayed and reduced anti-oxidant response), and an alteration in the immune cells' gene expression profile (increases in post-exercise interleukin-10 and toll-like receptor 4 gene expression), but not in circulating pro- or anti-inflammatory cytokines. Many of these immune changes relate to post-exertional malaise in CFS, a major characteristic of the illness. The literature review provides level B evidence for an altered immune response to exercise in patients with CFS. SN - 1077-5552 UR - https://www.unboundmedicine.com/medline/citation/24974723/Altered_immune_response_to_exercise_in_patients_with_chronic_fatigue_syndrome/myalgic_encephalomyelitis:_a_systematic_literature_review L2 - http://eir-isei.de/2014/eir-2014-094-article.pdf DB - PRIME DP - Unbound Medicine ER -