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Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats.
Pharmacol Biochem Behav. 2014 Sep; 124:290-6.PB

Abstract

Depression and anxiety are common comorbidities of neuropathic pain (NP). Pharmacological preclinical studies on NP have given abundant information on the effects of drugs on reflex measures of stimulus-evoked pain. However, few preclinical studies focus on relief of comorbidities evoked by NP. In this study, we investigated the effects of tramadol on nociceptive reflex, depression-associated and anxiety-related behaviors in a NP model in rats. We used chronic constriction injury (CCI) of the sciatic nerve as an animal model of neuropathic pain. We performed electronic von Frey tests (evF) to measure mechanical sensitivity, elevated plus maze tests (EPM) to record anxiety-related behaviors and forced swimming tests (FST) to evaluate depression-associated behaviors. In the evF, CCI rats showed a decrease of 82% of the paw withdrawal threshold (PWT) compared to sham (P<0.001). Tramadol increased the PWT by 336% in CCI rats (P<0.001) and by 16% in sham (P<0.05). On the EPM, CCI rats spent 45% less time than sham on the open arms of the maze (P<0.05). Tramadol increased the time spent on the open arms of CCI rats by 67% (P<0.05) and had no significant effect on sham. During the FST, CCI rats showed 28% longer immobility than sham (P<0.01). Tramadol reduced the immobility time in CCI rats by 22% (P<0.001), while having no effect on sham. Tramadol reversed the changes in mechanical sensitivity as well as anxiety-related and depression-associated behaviors that are caused by injury of the sciatic nerve with only minor effects in the absence of injury. These data suggest that tramadol relieves chronic pain and its indirect consequences and comorbidities, and that this study also is a model for pharmacological studies seeking to investigate the effect of drugs on the major disabling symptoms of NP.

Authors+Show Affiliations

Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Ludolf-Krehl-Str. 13, D-68167 Mannheim, Germany. Electronic address: Ombretta.Caspani@medma.uni-heidelberg.de.Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Ludolf-Krehl-Str. 13, D-68167 Mannheim, Germany.Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research, Birkendorfer Straβe 65, D-88397 Biberach/Riβ, Germany.Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research, Birkendorfer Straβe 65, D-88397 Biberach/Riβ, Germany.Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Ludolf-Krehl-Str. 13, D-68167 Mannheim, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24974768

Citation

Caspani, Ombretta, et al. "Tramadol Reduces Anxiety-related and Depression-associated Behaviors Presumably Induced By Pain in the Chronic Constriction Injury Model of Neuropathic Pain in Rats." Pharmacology, Biochemistry, and Behavior, vol. 124, 2014, pp. 290-6.
Caspani O, Reitz MC, Ceci A, et al. Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats. Pharmacol Biochem Behav. 2014;124:290-6.
Caspani, O., Reitz, M. C., Ceci, A., Kremer, A., & Treede, R. D. (2014). Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats. Pharmacology, Biochemistry, and Behavior, 124, 290-6. https://doi.org/10.1016/j.pbb.2014.06.018
Caspani O, et al. Tramadol Reduces Anxiety-related and Depression-associated Behaviors Presumably Induced By Pain in the Chronic Constriction Injury Model of Neuropathic Pain in Rats. Pharmacol Biochem Behav. 2014;124:290-6. PubMed PMID: 24974768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats. AU - Caspani,Ombretta, AU - Reitz,Marie-Céline, AU - Ceci,Angelo, AU - Kremer,Andreas, AU - Treede,Rolf-Detlef, Y1 - 2014/06/27/ PY - 2013/10/12/received PY - 2014/05/22/revised PY - 2014/06/20/accepted PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2015/5/20/medline KW - Anxiety KW - Depression KW - Elevated plus maze KW - Forced swimming test KW - Neuropathic pain KW - Tramadol SP - 290 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 124 N2 - Depression and anxiety are common comorbidities of neuropathic pain (NP). Pharmacological preclinical studies on NP have given abundant information on the effects of drugs on reflex measures of stimulus-evoked pain. However, few preclinical studies focus on relief of comorbidities evoked by NP. In this study, we investigated the effects of tramadol on nociceptive reflex, depression-associated and anxiety-related behaviors in a NP model in rats. We used chronic constriction injury (CCI) of the sciatic nerve as an animal model of neuropathic pain. We performed electronic von Frey tests (evF) to measure mechanical sensitivity, elevated plus maze tests (EPM) to record anxiety-related behaviors and forced swimming tests (FST) to evaluate depression-associated behaviors. In the evF, CCI rats showed a decrease of 82% of the paw withdrawal threshold (PWT) compared to sham (P<0.001). Tramadol increased the PWT by 336% in CCI rats (P<0.001) and by 16% in sham (P<0.05). On the EPM, CCI rats spent 45% less time than sham on the open arms of the maze (P<0.05). Tramadol increased the time spent on the open arms of CCI rats by 67% (P<0.05) and had no significant effect on sham. During the FST, CCI rats showed 28% longer immobility than sham (P<0.01). Tramadol reduced the immobility time in CCI rats by 22% (P<0.001), while having no effect on sham. Tramadol reversed the changes in mechanical sensitivity as well as anxiety-related and depression-associated behaviors that are caused by injury of the sciatic nerve with only minor effects in the absence of injury. These data suggest that tramadol relieves chronic pain and its indirect consequences and comorbidities, and that this study also is a model for pharmacological studies seeking to investigate the effect of drugs on the major disabling symptoms of NP. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/24974768/Tramadol_reduces_anxiety_related_and_depression_associated_behaviors_presumably_induced_by_pain_in_the_chronic_constriction_injury_model_of_neuropathic_pain_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(14)00188-9 DB - PRIME DP - Unbound Medicine ER -