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Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation.
Vet Clin Pathol. 2014 Sep; 43(3):437-46.VC

Abstract

BACKGROUND

Cerebrospinal fluid (CSF) is commonly acquired in dogs with intervertebral disk herniation (IVDH) and is a common method to assess inflammatory responses following spinal cord injury (SCI).

OBJECTIVES

The purpose of the study was to describe relationships between cisternal CSF characteristics, behavioral measures of SCI, T2- weighted (T2W) hyperintensity on magnetic resonance imaging (MRI), and long-term outcome in dogs with IVDH. Diagnostic accuracy of CSF for differentiating IVDH from other myelopathies was also assessed.

METHODS

The retrospective case series included 727 dogs, 443 with thoracolumbar IVDH, 103 with cervical IVDH, and 181 with other spinal cord diseases. Signalment, initial neurologic function, ambulatory function at long-term follow-up, T2W MRI, and CSF variables were recorded for dogs with IVDH. Signalment, etiology, and CSF data were retrieved for dogs with other myelopathies. Associations between CSF predictors, diagnosis, and outcomes were assessed.

RESULTS

CSF total nucleated cell count (TNCC) increased with SCI severity (rho -0.256, P < .001) in dogs with IVDH, TNCC was significantly higher in the presence of T2W hyperintensity (P = .001) in dogs with thoracolumbar IVDH, but TNCC, RBC count, microprotein, and percent neutrophils decreased with increasing injury duration (rho -0.253, P < .001; rho -0.269, P < .001; rho -0.141, P = .004, and rho -0.356, P < .001, respectively). CSF characteristics were not accurate for differentiating IVDH from other spinal cord diseases.

CONCLUSIONS

In dogs with IVDH, CSF TNCC, RBC count, microprotein, and percent neutrophils are correlated with clinical aspects of SCI such as injury severity and duration, but cannot differentiate IVDH from other etiologies.

Authors+Show Affiliations

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24976308

Citation

Levine, Gwendolyn J., et al. "Relationships Between Cerebrospinal Fluid Characteristics, Injury Severity, and Functional Outcome in Dogs With and Without Intervertebral Disk Herniation." Veterinary Clinical Pathology, vol. 43, no. 3, 2014, pp. 437-46.
Levine GJ, Cook JR, Kerwin SC, et al. Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation. Vet Clin Pathol. 2014;43(3):437-46.
Levine, G. J., Cook, J. R., Kerwin, S. C., Mankin, J., Griffin, J. F., Fosgate, G. T., & Levine, J. M. (2014). Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation. Veterinary Clinical Pathology, 43(3), 437-46. https://doi.org/10.1111/vcp.12165
Levine GJ, et al. Relationships Between Cerebrospinal Fluid Characteristics, Injury Severity, and Functional Outcome in Dogs With and Without Intervertebral Disk Herniation. Vet Clin Pathol. 2014;43(3):437-46. PubMed PMID: 24976308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation. AU - Levine,Gwendolyn J, AU - Cook,Jennifer R, AU - Kerwin,Sharon C, AU - Mankin,Joseph, AU - Griffin,John F, AU - Fosgate,Geoffrey T, AU - Levine,Jonathan M, Y1 - 2014/06/27/ PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2015/6/13/medline KW - Canine KW - locomotion KW - prognosis KW - spinal cord injury SP - 437 EP - 46 JF - Veterinary clinical pathology JO - Vet Clin Pathol VL - 43 IS - 3 N2 - BACKGROUND: Cerebrospinal fluid (CSF) is commonly acquired in dogs with intervertebral disk herniation (IVDH) and is a common method to assess inflammatory responses following spinal cord injury (SCI). OBJECTIVES: The purpose of the study was to describe relationships between cisternal CSF characteristics, behavioral measures of SCI, T2- weighted (T2W) hyperintensity on magnetic resonance imaging (MRI), and long-term outcome in dogs with IVDH. Diagnostic accuracy of CSF for differentiating IVDH from other myelopathies was also assessed. METHODS: The retrospective case series included 727 dogs, 443 with thoracolumbar IVDH, 103 with cervical IVDH, and 181 with other spinal cord diseases. Signalment, initial neurologic function, ambulatory function at long-term follow-up, T2W MRI, and CSF variables were recorded for dogs with IVDH. Signalment, etiology, and CSF data were retrieved for dogs with other myelopathies. Associations between CSF predictors, diagnosis, and outcomes were assessed. RESULTS: CSF total nucleated cell count (TNCC) increased with SCI severity (rho -0.256, P < .001) in dogs with IVDH, TNCC was significantly higher in the presence of T2W hyperintensity (P = .001) in dogs with thoracolumbar IVDH, but TNCC, RBC count, microprotein, and percent neutrophils decreased with increasing injury duration (rho -0.253, P < .001; rho -0.269, P < .001; rho -0.141, P = .004, and rho -0.356, P < .001, respectively). CSF characteristics were not accurate for differentiating IVDH from other spinal cord diseases. CONCLUSIONS: In dogs with IVDH, CSF TNCC, RBC count, microprotein, and percent neutrophils are correlated with clinical aspects of SCI such as injury severity and duration, but cannot differentiate IVDH from other etiologies. SN - 1939-165X UR - https://www.unboundmedicine.com/medline/citation/24976308/Relationships_between_cerebrospinal_fluid_characteristics_injury_severity_and_functional_outcome_in_dogs_with_and_without_intervertebral_disk_herniation_ L2 - https://doi.org/10.1111/vcp.12165 DB - PRIME DP - Unbound Medicine ER -