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Short-term effect of G-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus.
Nutrition. 2014 Oct; 30(10):1158-64.N

Abstract

OBJECTIVE

Salacia oblonga, Tinospora cordifolia, Emblica offinalis Gaertn, Curcuma longa and Gymnema sylvestre are Ayurvedic medicinal plants reported to lower plasma glucose levels in animal models. To our knowledge, however, no clinical validations of those extracts for efficacy have been. The aim of this study was to evaluate the effect of polyherbal combination in patients with type 2 diabetes mellitus.

METHODS

We screened 250 patients enrolled in a diabetes mellitus screening camp held at District Ayurvedic Hospital, Kottayam, Kerala, India. Of these, 89 patients diagnosed with type 2 diabetes mellitus and 50 healthy volunteers of similar age group were included in the study. Patients were treated with a polyherbal combination drug namely G-400 (1000 mg/d) for 8 wk with a follow-up of 2wk interval.

RESULTS

Fasting and postprandial blood glucose levels measured after 8 wk of G-400 treatment in patients were significantly lower. Indeed diabetic rats showed similar protection with G-400 administration. Furthermore, glycosylated hemoglobin, serum total cholesterol, both high- and low-density lipoprotein cholesterol, and triglycerides showed a significant improvement in G-400-administered patients. Toxicologic profile of the drug was assessed by analyzing the enzyme activities of alkaline phosphatase and alanine aminotransferase along with the concentration of blood urea nitrogen and creatinine in blood and found insignificant change compared with control.

CONCLUSION

Short-term supplementation of G-400 not only attenuates the hyperglycemia, but also acts as hypolipidemic agent in patients with diabetes. Further study should be done for the long-term effect of the drug in larger populations.

Authors+Show Affiliations

Department of Medical Biochemistry, School of Medical Education, Mahatma Gandhi University, Kottayam, India; School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India. Electronic address: kurian@scbt.sastra.edu.Department of Medical Biochemistry, School of Medical Education, Mahatma Gandhi University, Kottayam, India.Department of Medical Biochemistry, School of Medical Education, Mahatma Gandhi University, Kottayam, India.Department of Medical Biochemistry, School of Medical Education, Mahatma Gandhi University, Kottayam, India.Amala Cancer Research Centre, Thrissur, Kottayam, India.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24976431

Citation

Kurian, Gino A., et al. "Short-term Effect of G-400, Polyherbal Formulation in the Management of Hyperglycemia and Hyperlipidemia Conditions in Patients With Type 2 Diabetes Mellitus." Nutrition (Burbank, Los Angeles County, Calif.), vol. 30, no. 10, 2014, pp. 1158-64.
Kurian GA, Manjusha V, Nair SS, et al. Short-term effect of G-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus. Nutrition. 2014;30(10):1158-64.
Kurian, G. A., Manjusha, V., Nair, S. S., Varghese, T., & Padikkala, J. (2014). Short-term effect of G-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus. Nutrition (Burbank, Los Angeles County, Calif.), 30(10), 1158-64. https://doi.org/10.1016/j.nut.2014.02.026
Kurian GA, et al. Short-term Effect of G-400, Polyherbal Formulation in the Management of Hyperglycemia and Hyperlipidemia Conditions in Patients With Type 2 Diabetes Mellitus. Nutrition. 2014;30(10):1158-64. PubMed PMID: 24976431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effect of G-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus. AU - Kurian,Gino A, AU - Manjusha,V, AU - Nair,Sunitha S, AU - Varghese,Thomas, AU - Padikkala,Jose, Y1 - 2014/03/14/ PY - 2013/09/10/received PY - 2014/01/20/revised PY - 2014/02/15/accepted PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2015/5/13/medline KW - Ayurvedic medicine KW - Clinical trial KW - Poly herbal combination KW - Type 2 diabetes mellitus patients SP - 1158 EP - 64 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 30 IS - 10 N2 - OBJECTIVE: Salacia oblonga, Tinospora cordifolia, Emblica offinalis Gaertn, Curcuma longa and Gymnema sylvestre are Ayurvedic medicinal plants reported to lower plasma glucose levels in animal models. To our knowledge, however, no clinical validations of those extracts for efficacy have been. The aim of this study was to evaluate the effect of polyherbal combination in patients with type 2 diabetes mellitus. METHODS: We screened 250 patients enrolled in a diabetes mellitus screening camp held at District Ayurvedic Hospital, Kottayam, Kerala, India. Of these, 89 patients diagnosed with type 2 diabetes mellitus and 50 healthy volunteers of similar age group were included in the study. Patients were treated with a polyherbal combination drug namely G-400 (1000 mg/d) for 8 wk with a follow-up of 2wk interval. RESULTS: Fasting and postprandial blood glucose levels measured after 8 wk of G-400 treatment in patients were significantly lower. Indeed diabetic rats showed similar protection with G-400 administration. Furthermore, glycosylated hemoglobin, serum total cholesterol, both high- and low-density lipoprotein cholesterol, and triglycerides showed a significant improvement in G-400-administered patients. Toxicologic profile of the drug was assessed by analyzing the enzyme activities of alkaline phosphatase and alanine aminotransferase along with the concentration of blood urea nitrogen and creatinine in blood and found insignificant change compared with control. CONCLUSION: Short-term supplementation of G-400 not only attenuates the hyperglycemia, but also acts as hypolipidemic agent in patients with diabetes. Further study should be done for the long-term effect of the drug in larger populations. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/24976431/Short_term_effect_of_G_400_polyherbal_formulation_in_the_management_of_hyperglycemia_and_hyperlipidemia_conditions_in_patients_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00132-4 DB - PRIME DP - Unbound Medicine ER -