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Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis.
World J Gastroenterol. 2014 Jun 28; 20(24):7941-9.WJ

Abstract

AIM

To examine the association between obesity-related adipokines (adiponectin, leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and colorectal cancer (CRC) risk.

METHODS

Serum levels of adipokines were measured in 100 CRC patients and age- and sex-matched controls for the data analysis. Unconditional logistic regression models were used for estimating ORs and 95%CIs related to each adipokine. For the meta-analysis, studies published before July 2013 available on Medline/PubMed and EMBASE were retrieved. The analysis included a total of 17 relevant studies (including the present case-control study): nine studies on adiponectin and eight on leptin. The effect sizes of ORs and 95%CIs were estimated using RevMan 5.1. Heterogeneity was evaluated using Cochran's Q-test and I (2) statistics.

RESULTS

Among the five adipokines, only resistin levels were significantly higher in cases than in controls (P < 0.001). The case-control study results showed no association between adiponectin and CRC and a negative association between leptin and CRC. However, the results of the meta-analysis showed a significant inverse association between adiponectin and CRC (OR = 0.91, 95%CI: 0.83-1.00, P = 0.04) and no association between CRC and leptin. After stratification by study design, an inverse association between adiponectin and CRC was observed in prospective studies only (OR = 0.90, 95%CI: 0.82-0.99, P = 0.03), whereas the association between leptin and CRC was inconsistent (prospective studies: OR = 1.14, 95%CI: 1.02-1.27, P = 0.02 and retrospective studies: OR = 0.47, 95%CI: 0.29-0.74, P = 0.001). The associations of resistin and TNF-α with CRC risk were positive, but no association was observed for IL-6.

CONCLUSION

Our results suggest a negative association of leptin, positive associations of resistin and TNF-α, and null associations of adiponectin and IL-6 with CRC. However, further studies with larger number of prospective approaches are needed.

Authors+Show Affiliations

Rakhi Kumari Joshi, Sang-Ah Lee, Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-701, South Korea.Rakhi Kumari Joshi, Sang-Ah Lee, Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-701, South Korea.Rakhi Kumari Joshi, Sang-Ah Lee, Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-701, South Korea.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24976730

Citation

Joshi, Rakhi Kumari, et al. "Association Between Obesity-related Adipokines and Colorectal Cancer: a Case-control Study and Meta-analysis." World Journal of Gastroenterology, vol. 20, no. 24, 2014, pp. 7941-9.
Joshi RK, Kim WJ, Lee SA. Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis. World J Gastroenterol. 2014;20(24):7941-9.
Joshi, R. K., Kim, W. J., & Lee, S. A. (2014). Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis. World Journal of Gastroenterology, 20(24), 7941-9. https://doi.org/10.3748/wjg.v20.i24.7941
Joshi RK, Kim WJ, Lee SA. Association Between Obesity-related Adipokines and Colorectal Cancer: a Case-control Study and Meta-analysis. World J Gastroenterol. 2014 Jun 28;20(24):7941-9. PubMed PMID: 24976730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis. AU - Joshi,Rakhi Kumari, AU - Kim,Woo Jin, AU - Lee,Sang-Ah, PY - 2013/10/25/received PY - 2014/01/24/revised PY - 2014/04/08/accepted PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2015/4/14/medline KW - Adipokines KW - Cancer risk KW - Colorectal cancer KW - Obesity KW - Obesity-related adipokines SP - 7941 EP - 9 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 24 N2 - AIM: To examine the association between obesity-related adipokines (adiponectin, leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and colorectal cancer (CRC) risk. METHODS: Serum levels of adipokines were measured in 100 CRC patients and age- and sex-matched controls for the data analysis. Unconditional logistic regression models were used for estimating ORs and 95%CIs related to each adipokine. For the meta-analysis, studies published before July 2013 available on Medline/PubMed and EMBASE were retrieved. The analysis included a total of 17 relevant studies (including the present case-control study): nine studies on adiponectin and eight on leptin. The effect sizes of ORs and 95%CIs were estimated using RevMan 5.1. Heterogeneity was evaluated using Cochran's Q-test and I (2) statistics. RESULTS: Among the five adipokines, only resistin levels were significantly higher in cases than in controls (P < 0.001). The case-control study results showed no association between adiponectin and CRC and a negative association between leptin and CRC. However, the results of the meta-analysis showed a significant inverse association between adiponectin and CRC (OR = 0.91, 95%CI: 0.83-1.00, P = 0.04) and no association between CRC and leptin. After stratification by study design, an inverse association between adiponectin and CRC was observed in prospective studies only (OR = 0.90, 95%CI: 0.82-0.99, P = 0.03), whereas the association between leptin and CRC was inconsistent (prospective studies: OR = 1.14, 95%CI: 1.02-1.27, P = 0.02 and retrospective studies: OR = 0.47, 95%CI: 0.29-0.74, P = 0.001). The associations of resistin and TNF-α with CRC risk were positive, but no association was observed for IL-6. CONCLUSION: Our results suggest a negative association of leptin, positive associations of resistin and TNF-α, and null associations of adiponectin and IL-6 with CRC. However, further studies with larger number of prospective approaches are needed. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24976730/Association_between_obesity_related_adipokines_and_colorectal_cancer:_a_case_control_study_and_meta_analysis_ L2 - http://www.wjgnet.com/1007-9327/full/v20/i24/7941.htm DB - PRIME DP - Unbound Medicine ER -