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Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran.
Transplantation 2014; 98(1):66-71T

Abstract

INTRODUCTION

Hyperhomocysteinemia (hyperHcy) is an important risk factor for atherosclerosis, which is currently a major cause of death in renal transplant patients (RTRs). The aim of this study was to determine the associated factors of hyperHcy in RTRs in northern Iran.

METHODS

In 148 stable RTRs, total serum homocysteine (tHcy) level, folate, serum albumin and creatinine, creatinine clearance, lipid status, body mass index (BMI), and blood cyclosporine levels (C0 and C2) were determined. The mean doses of cyclosporine A (mg/kg/day) were recorded.

RESULTS

In this analytic cross-sectional study the prevalence of hyperHcy was 70.3%. Hyperhomocysteinemia was defined as total serum homocysteine of 12 μmol/L or greater. The comparison of the group of 44 patients with tHcy level less than 12 and the group of 104 patients with tHcy level of 12 μmol/L or greater revealed that those subjects with hyperHcy were mostly younger, male, with lower BMI, history of glomerulonephritis, higher serum level of uric acid, and blood cyclosporine trough level (C0) and used higher doses of cyclosporine A. Significant correlation was found between tHcy level and recipients age, serum creatinine, BUN, folate concentrations, and creatinine clearance. However, multivariate analysis indicated that serum folate (P=0.01), vitamin B12 (P=0.05), creatinine (P=0.03), and BUN (P=0.05), and blood cyclosporine trough level (C0, P=0.005) were independently associated with tHcy levels.

CONCLUSION

HyperHcy persists after successful kidney transplantation in the majority of RTRs. Serum creatinine, BUN, folate and vitamin B12, and blood cyclosporine trough level (C0) are independently associated with tHcy levels.

Authors+Show Affiliations

1 Urology Research Center, School of Medical, Guilan University of Medical Sciences, Rasht, Iran. 2 School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. 3 Address correspondence to: Seyyede Zeinab Azimi, M.D., Urology Research Center, School of Medical, Guilan University of Medical Sciences, Department of Nephrology, Razi Hospital, Rasht, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24978036

Citation

Monfared, Ali, et al. "Hyperhomocysteinemia and Assessment of Its Associated Factors in Renal Transplant Recipients: a Single-center Study in Northern Iran." Transplantation, vol. 98, no. 1, 2014, pp. 66-71.
Monfared A, Azimi SZ, Kazemnezhad E, et al. Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran. Transplantation. 2014;98(1):66-71.
Monfared, A., Azimi, S. Z., Kazemnezhad, E., Khosravi, M., Lebadi, M., Mirzajani, E., & Ashtiani, M. N. (2014). Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran. Transplantation, 98(1), pp. 66-71. doi:10.1097/01.TP.0000443222.82207.3d.
Monfared A, et al. Hyperhomocysteinemia and Assessment of Its Associated Factors in Renal Transplant Recipients: a Single-center Study in Northern Iran. Transplantation. 2014 Jul 15;98(1):66-71. PubMed PMID: 24978036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran. AU - Monfared,Ali, AU - Azimi,Seyyede Zeinab, AU - Kazemnezhad,Ehsan, AU - Khosravi,Masoud, AU - Lebadi,Mohammadkazem, AU - Mirzajani,Ebrahim, AU - Ashtiani,Mohammad Najafi, PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2014/9/3/medline SP - 66 EP - 71 JF - Transplantation JO - Transplantation VL - 98 IS - 1 N2 - INTRODUCTION: Hyperhomocysteinemia (hyperHcy) is an important risk factor for atherosclerosis, which is currently a major cause of death in renal transplant patients (RTRs). The aim of this study was to determine the associated factors of hyperHcy in RTRs in northern Iran. METHODS: In 148 stable RTRs, total serum homocysteine (tHcy) level, folate, serum albumin and creatinine, creatinine clearance, lipid status, body mass index (BMI), and blood cyclosporine levels (C0 and C2) were determined. The mean doses of cyclosporine A (mg/kg/day) were recorded. RESULTS: In this analytic cross-sectional study the prevalence of hyperHcy was 70.3%. Hyperhomocysteinemia was defined as total serum homocysteine of 12 μmol/L or greater. The comparison of the group of 44 patients with tHcy level less than 12 and the group of 104 patients with tHcy level of 12 μmol/L or greater revealed that those subjects with hyperHcy were mostly younger, male, with lower BMI, history of glomerulonephritis, higher serum level of uric acid, and blood cyclosporine trough level (C0) and used higher doses of cyclosporine A. Significant correlation was found between tHcy level and recipients age, serum creatinine, BUN, folate concentrations, and creatinine clearance. However, multivariate analysis indicated that serum folate (P=0.01), vitamin B12 (P=0.05), creatinine (P=0.03), and BUN (P=0.05), and blood cyclosporine trough level (C0, P=0.005) were independently associated with tHcy levels. CONCLUSION: HyperHcy persists after successful kidney transplantation in the majority of RTRs. Serum creatinine, BUN, folate and vitamin B12, and blood cyclosporine trough level (C0) are independently associated with tHcy levels. SN - 1534-6080 UR - https://www.unboundmedicine.com/medline/citation/24978036/Hyperhomocysteinemia_and_assessment_of_its_associated_factors_in_renal_transplant_recipients:_a_single_center_study_in_northern_Iran_ L2 - http://Insights.ovid.com/pubmed?pmid=24978036 DB - PRIME DP - Unbound Medicine ER -