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Is cetrimide-chlorhexidine risky for secondary sclerosing cholangitis?
Adv Clin Exp Med 2014 May-Jun; 23(3):395-8AC

Abstract

BACKGROUND

The liver is the most frequent organ for placement of hydatid cyst disease. All known protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The cetrimide-chlorhexidine combination is an effective protoscolicidal agent for treatment of hydatid liver cysts.

OBJECTIVES

The aim of this experimental study was to examine this combination for potential risks of caustic secondary sclerosing cholangitis.

MATERIAL AND METHODS

Thirty rats were enrolled and divided into two groups. In the study group, 0.15 mL of a cetrimide (0.5%) and chlorhexidine (0.05%) combination was injected into the bile ducts for five minutes. The control group included the same amount of normal saline and waiting period. The rats were followed for 120 days and the living rats were examined for biliary injury by biochemical analysis and histopathology.

RESULTS

No specific histopathological findings for caustic sclerosing cholangitis such as bile duct stricture or periductal fibrosis were present in any groups. Other pathological criteria demonstrating inflammation including portal inflammation, bile duct proliferation and necrosis were similar in both groups. Biochemical analysis including a liver function test (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase) appeared similar to the control group.

CONCLUSIONS

A cetrimide 0.5% and chlorhexidine 0.05% combination has similar liver function results and histopathological effects to normal saline on bile ducts and it appears to be safe for bile ducts.

Authors+Show Affiliations

Inonu University, Turgut Ozal Medical Center, Department of General Surgery, Malatya, Turkey.Inonu University, Turgut Ozal Medical Center, Department of General Surgery, Malatya, Turkey.Turkey Yuksek Ihtisas Hospital, Department of Gastrointestinal Surgery, Ankara, Turke.Turkey Yuksek Ihtisas Hospital, Department of Gastrointestinal Surgery, Ankara, Turke.Gulhane Military Medicine Academy, Department of General Surgery, Ankara, Turkey.Inonu University, Turgut Ozal Medical Center, Department of General Surgery, Malatya, Turkey.Gulhane Military Medicine Academy, Department of General Surgery, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24979510

Citation

Aydin, Cemalettin, et al. "Is Cetrimide-chlorhexidine Risky for Secondary Sclerosing Cholangitis?" Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, vol. 23, no. 3, 2014, pp. 395-8.
Aydin C, Kayaalp C, Nessar G, et al. Is cetrimide-chlorhexidine risky for secondary sclerosing cholangitis? Adv Clin Exp Med. 2014;23(3):395-8.
Aydin, C., Kayaalp, C., Nessar, G., Zengin, N., Balkan, M., Unal, B., & Ozgurtas, T. (2014). Is cetrimide-chlorhexidine risky for secondary sclerosing cholangitis? Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 23(3), pp. 395-8.
Aydin C, et al. Is Cetrimide-chlorhexidine Risky for Secondary Sclerosing Cholangitis. Adv Clin Exp Med. 2014;23(3):395-8. PubMed PMID: 24979510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is cetrimide-chlorhexidine risky for secondary sclerosing cholangitis? AU - Aydin,Cemalettin, AU - Kayaalp,Cuneyt, AU - Nessar,Gurel, AU - Zengin,Neslihan, AU - Balkan,Mujdat, AU - Unal,Bulent, AU - Ozgurtas,Taner, PY - 2014/7/1/entrez PY - 2014/7/1/pubmed PY - 2014/10/1/medline SP - 395 EP - 8 JF - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JO - Adv Clin Exp Med VL - 23 IS - 3 N2 - BACKGROUND: The liver is the most frequent organ for placement of hydatid cyst disease. All known protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The cetrimide-chlorhexidine combination is an effective protoscolicidal agent for treatment of hydatid liver cysts. OBJECTIVES: The aim of this experimental study was to examine this combination for potential risks of caustic secondary sclerosing cholangitis. MATERIAL AND METHODS: Thirty rats were enrolled and divided into two groups. In the study group, 0.15 mL of a cetrimide (0.5%) and chlorhexidine (0.05%) combination was injected into the bile ducts for five minutes. The control group included the same amount of normal saline and waiting period. The rats were followed for 120 days and the living rats were examined for biliary injury by biochemical analysis and histopathology. RESULTS: No specific histopathological findings for caustic sclerosing cholangitis such as bile duct stricture or periductal fibrosis were present in any groups. Other pathological criteria demonstrating inflammation including portal inflammation, bile duct proliferation and necrosis were similar in both groups. Biochemical analysis including a liver function test (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase) appeared similar to the control group. CONCLUSIONS: A cetrimide 0.5% and chlorhexidine 0.05% combination has similar liver function results and histopathological effects to normal saline on bile ducts and it appears to be safe for bile ducts. SN - 1899-5276 UR - https://www.unboundmedicine.com/medline/citation/24979510/Is_cetrimide_chlorhexidine_risky_for_secondary_sclerosing_cholangitis L2 - http://www.advances.am.wroc.pl/pdf/2014/23/3/395.pdf DB - PRIME DP - Unbound Medicine ER -