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Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: frequency and contributing factors.
Am J Rhinol Allergy. 2014 May-Jun; 28(3):239-43.AJ

Abstract

BACKGROUND

Aspirin-exacerbated respiratory disease (AERD) is a syndrome frequently seen in patients with chronic rhinosinusitis and nasal polyposis (CRSwNP). However, there are few studies on evaluating the prevalence of aspirin (acetylsalicylic acid [ASA]) hypersensitivity in patients with CRSwNP using the oral aspirin challenge (OAC) test. This cross-sectional study was designed to determine the frequency of ASA hypersensitivity and factors associated with it in patients with CRSwNP in Tehran, Iran.

METHODS

Adult patients with CRSwNP who were presented to the asthma and allergy clinic were recruited for the study. After confirming CRS and NP, OAC was performed to evaluate/confirm the diagnosis of ASA hypersensitivity. Atopic evaluation was performed using skin-prick test, nasal smear, blood eosinophil count, and serum total IgE.

RESULTS

Eighty Iranian patients (43 women and 37 men) with CRSwNP were enrolled (mean age, 38.9 ± 10.7 years). OAC was performed in all of the patients and 39 patients (48.8%) had a positive reaction; among them, 14 (35.8%) had a self-reported history of ASA hypersensitivity. Concomitant asthma, previous polyp surgery, high polyp score, and ASA hypersensitivity history were all associated with positive OAC (p < 0.05). Presence of AERD was not associated with age, stage of asthma, blood eosinophilia, nasal smear eosinophilia, and atopy.

CONCLUSION

ASA hypersensitivity is common in patients with CRSwNP in Tehran, Iran. Patients at risk for AERD should be evaluated for the presence of ASA hypersensitivity with ASA provocation challenge test to confirm the diagnosis.

Authors+Show Affiliations

Department of Allergy and Immunology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24980235

Citation

Nabavi, Mohammad, et al. "Aspirin Hypersensitivity in Patients With Chronic Rhinosinusitis and Nasal Polyposis: Frequency and Contributing Factors." American Journal of Rhinology & Allergy, vol. 28, no. 3, 2014, pp. 239-43.
Nabavi M, Esmaeilzadeh H, Arshi S, et al. Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: frequency and contributing factors. Am J Rhinol Allergy. 2014;28(3):239-43.
Nabavi, M., Esmaeilzadeh, H., Arshi, S., Bemanian, M. H., Fallahpour, M., Bahrami, A., Mortazavi, N., Kamrava, K., Farhadi, M., Taghipour, R., & Rezaei, N. (2014). Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: frequency and contributing factors. American Journal of Rhinology & Allergy, 28(3), 239-43. https://doi.org/10.2500/ajra.2014.28.4034
Nabavi M, et al. Aspirin Hypersensitivity in Patients With Chronic Rhinosinusitis and Nasal Polyposis: Frequency and Contributing Factors. Am J Rhinol Allergy. 2014 May-Jun;28(3):239-43. PubMed PMID: 24980235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: frequency and contributing factors. AU - Nabavi,Mohammad, AU - Esmaeilzadeh,Hossein, AU - Arshi,Saba, AU - Bemanian,Mohammad Hassan, AU - Fallahpour,Morteza, AU - Bahrami,Ahmad, AU - Mortazavi,Negar, AU - Kamrava,Kamran, AU - Farhadi,Mohammad, AU - Taghipour,Reza, AU - Rezaei,Nima, PY - 2014/7/2/entrez PY - 2014/7/2/pubmed PY - 2015/4/17/medline SP - 239 EP - 43 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 28 IS - 3 N2 - BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a syndrome frequently seen in patients with chronic rhinosinusitis and nasal polyposis (CRSwNP). However, there are few studies on evaluating the prevalence of aspirin (acetylsalicylic acid [ASA]) hypersensitivity in patients with CRSwNP using the oral aspirin challenge (OAC) test. This cross-sectional study was designed to determine the frequency of ASA hypersensitivity and factors associated with it in patients with CRSwNP in Tehran, Iran. METHODS: Adult patients with CRSwNP who were presented to the asthma and allergy clinic were recruited for the study. After confirming CRS and NP, OAC was performed to evaluate/confirm the diagnosis of ASA hypersensitivity. Atopic evaluation was performed using skin-prick test, nasal smear, blood eosinophil count, and serum total IgE. RESULTS: Eighty Iranian patients (43 women and 37 men) with CRSwNP were enrolled (mean age, 38.9 ± 10.7 years). OAC was performed in all of the patients and 39 patients (48.8%) had a positive reaction; among them, 14 (35.8%) had a self-reported history of ASA hypersensitivity. Concomitant asthma, previous polyp surgery, high polyp score, and ASA hypersensitivity history were all associated with positive OAC (p < 0.05). Presence of AERD was not associated with age, stage of asthma, blood eosinophilia, nasal smear eosinophilia, and atopy. CONCLUSION: ASA hypersensitivity is common in patients with CRSwNP in Tehran, Iran. Patients at risk for AERD should be evaluated for the presence of ASA hypersensitivity with ASA provocation challenge test to confirm the diagnosis. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/24980235/Aspirin_hypersensitivity_in_patients_with_chronic_rhinosinusitis_and_nasal_polyposis:_frequency_and_contributing_factors_ DB - PRIME DP - Unbound Medicine ER -