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Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men.
Br J Dermatol. 2014 Nov; 171(5):1052-9.BJ

Abstract

BACKGROUND

Androgenetic alopecia (AGA) is the most common type of baldness in men. The balding process is associated with the gradual miniaturization of hair follicles and successive hair loss. However, the relative contributions of hair density and diameter to AGA are still unclear.

OBJECTIVES

Hair density and hair diameter were investigated in Japanese men with or without AGA to elucidate the importance of these factors in the balding process.

METHODS

Male Japanese subjects with or without AGA (n = 369) were included in this study. Hair appearance at the vertex was evaluated by comparison with a series of standard photographs. Hair density was measured using a phototrichogram-based videomicroscopy technique, and hair diameter was assessed by comparison with a series of calibrated threads on the phototrichogram image.

RESULTS

All subjects with AGA were ≥ 25 years of age. The mean percentage of thick hairs (> 80 μm) in all subjects with AGA was significantly lower than that in subjects without AGA aged ≥ 25 years (P < 0·01), but the mean percentage of vellus hairs (< 40 μm) in subjects with AGA was significantly higher (P < 0·001). By contrast, the mean density of the hair in all patients with AGA did not significantly differ from the density of those without AGA aged ≥ 25 years. However, the mean density of the hair in subjects without AGA aged < 25 years was significantly higher than that of both subjects without AGA aged ≥ 25 years (P < 0·001) and all subjects with AGA.

CONCLUSIONS

Hair loss in men with AGA results mainly from the miniaturization of hair follicles rather than the loss of hair (shedding), at least for individuals who are ≥ 25 years of age and present with AGA.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ishino A
Shiseido Research Center, 2-2-1 Hayabuchi, Tsuzuki, Yokohama, Kanagawa, 224-8558, Japan.
Takahashi T
No affiliation info available
Suzuki J
No affiliation info available
Nakazawa Y
No affiliation info available
Iwabuchi T
No affiliation info available
Tajima M
No affiliation info available

MeSH

AdolescentAdultAge DistributionAlopeciaDisease ProgressionHairHumansJapanMaleMicroscopy, VideoMiddle AgedOrgan SizePhotographyYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24981717

Citation

Ishino, A, et al. "Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men." The British Journal of Dermatology, vol. 171, no. 5, 2014, pp. 1052-9.
Ishino A, Takahashi T, Suzuki J, et al. Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men. Br J Dermatol. 2014;171(5):1052-9.
Ishino, A., Takahashi, T., Suzuki, J., Nakazawa, Y., Iwabuchi, T., & Tajima, M. (2014). Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men. The British Journal of Dermatology, 171(5), 1052-9. https://doi.org/10.1111/bjd.13230
Ishino A, et al. Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men. Br J Dermatol. 2014;171(5):1052-9. PubMed PMID: 24981717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men. AU - Ishino,A, AU - Takahashi,T, AU - Suzuki,J, AU - Nakazawa,Y, AU - Iwabuchi,T, AU - Tajima,M, Y1 - 2014/10/19/ PY - 2014/06/27/accepted PY - 2014/7/2/entrez PY - 2014/7/2/pubmed PY - 2015/7/8/medline SP - 1052 EP - 9 JF - The British journal of dermatology JO - Br J Dermatol VL - 171 IS - 5 N2 - BACKGROUND: Androgenetic alopecia (AGA) is the most common type of baldness in men. The balding process is associated with the gradual miniaturization of hair follicles and successive hair loss. However, the relative contributions of hair density and diameter to AGA are still unclear. OBJECTIVES: Hair density and hair diameter were investigated in Japanese men with or without AGA to elucidate the importance of these factors in the balding process. METHODS: Male Japanese subjects with or without AGA (n = 369) were included in this study. Hair appearance at the vertex was evaluated by comparison with a series of standard photographs. Hair density was measured using a phototrichogram-based videomicroscopy technique, and hair diameter was assessed by comparison with a series of calibrated threads on the phototrichogram image. RESULTS: All subjects with AGA were ≥ 25 years of age. The mean percentage of thick hairs (> 80 μm) in all subjects with AGA was significantly lower than that in subjects without AGA aged ≥ 25 years (P < 0·01), but the mean percentage of vellus hairs (< 40 μm) in subjects with AGA was significantly higher (P < 0·001). By contrast, the mean density of the hair in all patients with AGA did not significantly differ from the density of those without AGA aged ≥ 25 years. However, the mean density of the hair in subjects without AGA aged < 25 years was significantly higher than that of both subjects without AGA aged ≥ 25 years (P < 0·001) and all subjects with AGA. CONCLUSIONS: Hair loss in men with AGA results mainly from the miniaturization of hair follicles rather than the loss of hair (shedding), at least for individuals who are ≥ 25 years of age and present with AGA. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/24981717/Contribution_of_hair_density_and_hair_diameter_to_the_appearance_and_progression_of_androgenetic_alopecia_in_Japanese_men_ DB - PRIME DP - Unbound Medicine ER -