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Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial.
Nutrition 2014 Jul-Aug; 30(7-8):814-21N

Abstract

OBJECTIVE

There are several reports regarding the role of therapeutic diets for patients with non-alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to determine the effects of a low-calorie, low-carbohydrate soy-containing diet on lipid profiles, liver enzymes, and coagulating factors in patients with NAFLD.

METHOD

This was a randomized parallel clinical trial involving 45 patients with NAFLD. The participants consumed three kinds of diets for 8 wk. Patients were randomly assigned to consume a low-calorie diet; a low-calorie, low-carbohydrate diet; or a low-calorie, low-carbohydrate soy-containing diet. Measurements were done according to the standard method.

RESULTS

Changes in weight were not significantly different in the three groups. The low-calorie, low-carbohydrate soy-containing diet could reduce alanine aminotransferase (-15.2 ± 12.1 versus -6.8 ± 4.6 in the low-calorie, low-carbohydrate diet, and -6.4 ± 4.4 IU/L in the low-calorie diet; P = 0.02) and serum fibrinogen levels (-49.1 ± 60.1 versus -12.9 ± 8.1 and -17.4 ± 8.4 g/L, respectively; P = 0.01). Reductions in aspartate aminotransferase were significantly higher in the low-calorie, low-carbohydrate soy-containing group. Changes in lipid profiles did not differ significantly between the groups. The soy-containing diet did reduce malondialdehyde more than the other diets (P = 0.01).

CONCLUSION

A low-calorie, low-carbohydrate soy-containing diet could have beneficial effects on liver enzymes, malondialdehyde, and serum fibrinogen levels in patients with NAFLD.

Authors+Show Affiliations

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Azadbakht@hlth.mui.ac.ir.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24984998

Citation

Kani, Ali Hashemi, et al. "Effects of a Novel Therapeutic Diet On Liver Enzymes and Coagulating Factors in Patients With Non-alcoholic Fatty Liver Disease: a Parallel Randomized Trial." Nutrition (Burbank, Los Angeles County, Calif.), vol. 30, no. 7-8, 2014, pp. 814-21.
Kani AH, Alavian SM, Esmaillzadeh A, et al. Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial. Nutrition. 2014;30(7-8):814-21.
Kani, A. H., Alavian, S. M., Esmaillzadeh, A., Adibi, P., & Azadbakht, L. (2014). Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial. Nutrition (Burbank, Los Angeles County, Calif.), 30(7-8), pp. 814-21. doi:10.1016/j.nut.2013.11.008.
Kani AH, et al. Effects of a Novel Therapeutic Diet On Liver Enzymes and Coagulating Factors in Patients With Non-alcoholic Fatty Liver Disease: a Parallel Randomized Trial. Nutrition. 2014;30(7-8):814-21. PubMed PMID: 24984998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease: A parallel randomized trial. AU - Kani,Ali Hashemi, AU - Alavian,Seyed Moayed, AU - Esmaillzadeh,Ahmad, AU - Adibi,Peyman, AU - Azadbakht,Leila, Y1 - 2013/12/02/ PY - 2013/07/21/received PY - 2013/11/25/revised PY - 2013/11/25/accepted PY - 2014/7/3/entrez PY - 2014/7/6/pubmed PY - 2015/2/11/medline KW - Coagulation KW - Lipid abnormalities KW - Low-calorie diet KW - Low-carbohydrate diet KW - Non-alcoholic fatty liver KW - Soy SP - 814 EP - 21 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 30 IS - 7-8 N2 - OBJECTIVE: There are several reports regarding the role of therapeutic diets for patients with non-alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to determine the effects of a low-calorie, low-carbohydrate soy-containing diet on lipid profiles, liver enzymes, and coagulating factors in patients with NAFLD. METHOD: This was a randomized parallel clinical trial involving 45 patients with NAFLD. The participants consumed three kinds of diets for 8 wk. Patients were randomly assigned to consume a low-calorie diet; a low-calorie, low-carbohydrate diet; or a low-calorie, low-carbohydrate soy-containing diet. Measurements were done according to the standard method. RESULTS: Changes in weight were not significantly different in the three groups. The low-calorie, low-carbohydrate soy-containing diet could reduce alanine aminotransferase (-15.2 ± 12.1 versus -6.8 ± 4.6 in the low-calorie, low-carbohydrate diet, and -6.4 ± 4.4 IU/L in the low-calorie diet; P = 0.02) and serum fibrinogen levels (-49.1 ± 60.1 versus -12.9 ± 8.1 and -17.4 ± 8.4 g/L, respectively; P = 0.01). Reductions in aspartate aminotransferase were significantly higher in the low-calorie, low-carbohydrate soy-containing group. Changes in lipid profiles did not differ significantly between the groups. The soy-containing diet did reduce malondialdehyde more than the other diets (P = 0.01). CONCLUSION: A low-calorie, low-carbohydrate soy-containing diet could have beneficial effects on liver enzymes, malondialdehyde, and serum fibrinogen levels in patients with NAFLD. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/24984998/Effects_of_a_novel_therapeutic_diet_on_liver_enzymes_and_coagulating_factors_in_patients_with_non_alcoholic_fatty_liver_disease:_A_parallel_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(13)00536-4 DB - PRIME DP - Unbound Medicine ER -