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On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process.
Biointerphases. 2014 Jun; 9(2):029013.B

Abstract

Environmental surfaces are increasingly recognized as important sources of transmission of hospital-acquired infections. The use of antibacterial surface coatings may constitute an effective solution to reduce the spread of contamination in healthcare settings, provided that they exhibit sufficient stability and a long-term antibacterial effect. In this study, silver-incorporated diamondlike carbon films (Ag-DLC) were prepared in a continuous, single-step plasma process using a hybrid, inductively coupled plasma reactor combined with a very-low-frequency sputtering setup. The average Ag concentration in the films, ranging from 0 to 2.4 at. %, was controlled by varying the sputtering bias on the silver target. The authors found that the activity of Escherichia coli was reduced by 2.5 orders of magnitude, compared with the control surface, after a 4-h contact with a 2.4 at. % Ag-DLC coating. The coatings displayed slow release kinetics, with a total silver ion release in the sub-ppb range after 4 h in solution, as measured by graphite furnace-atomic absorption spectroscopy. This was confirmed by Kirby-Bauer diffusion tests, which showed limited diffusion of biocidal silver with a localized antibacterial effect. As a slow and continuous release is mandatory to ensure a lasting antibacterial effect, the newly developed Ag-DLC coatings appears as promising materials for environmental hospital surfaces.

Authors+Show Affiliations

Laboratory for Biomaterials and Bioengineering (CRC I), Department of Min-Met-Materials Engineering and University Hospital Research Center, Laval University, Quebec City, Quebec G1A 0V6, Canada and Laboratoire Procédés, Plasmas, Microsystèmes (2PM), Institut de Recherche de Chimie Paris, CNRS - Chimie ParisTech, UPMC, 11 rue Pierre et Marie Curie, 75005 Paris, France.Laboratory for Biomaterials and Bioengineering (CRC I), Department of Min-Met-Materials Engineering and University Hospital Research Center, Laval University, Quebec City, Quebec G1A 0V6, Canada.Laboratory for Biomaterials and Bioengineering (CRC I), Department of Min-Met-Materials Engineering and University Hospital Research Center, Laval University, Quebec City, Quebec G1A 0V6, Canada and Laboratoire Procédés, Plasmas, Microsystèmes (2PM), Institut de Recherche de Chimie Paris, CNRS - Chimie ParisTech, UPMC, 11 rue Pierre et Marie Curie, 75005 Paris, France.Laboratory for Biomaterials and Bioengineering (CRC I), Department of Min-Met-Materials Engineering and University Hospital Research Center, Laval University, Quebec City, Quebec G1A 0V6, Canada.Laboratory for Biomaterials and Bioengineering (CRC I), Department of Min-Met-Materials Engineering and University Hospital Research Center, Laval University, Quebec City, Quebec G1A 0V6, Canada.Laboratoire Procédés, Plasmas, Microsystèmes (2PM), Institut de Recherche de Chimie Paris, CNRS - Chimie ParisTech, UPMC, 11 rue Pierre et Marie Curie, 75005 Paris, France.Laboratory for Biomaterials and Bioengineering (CRC I), Department of Min-Met-Materials Engineering and University Hospital Research Center, Laval University, Quebec City, Quebec G1A 0V6, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24985217

Citation

Cloutier, Maxime, et al. "On the Long Term Antibacterial Features of Silver-doped Diamondlike Carbon Coatings Deposited Via a Hybrid Plasma Process." Biointerphases, vol. 9, no. 2, 2014, p. 029013.
Cloutier M, Tolouei R, Lesage O, et al. On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process. Biointerphases. 2014;9(2):029013.
Cloutier, M., Tolouei, R., Lesage, O., Lévesque, L., Turgeon, S., Tatoulian, M., & Mantovani, D. (2014). On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process. Biointerphases, 9(2), 029013. https://doi.org/10.1116/1.4871435
Cloutier M, et al. On the Long Term Antibacterial Features of Silver-doped Diamondlike Carbon Coatings Deposited Via a Hybrid Plasma Process. Biointerphases. 2014;9(2):029013. PubMed PMID: 24985217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process. AU - Cloutier,Maxime, AU - Tolouei,Ranna, AU - Lesage,Olivier, AU - Lévesque,Lucie, AU - Turgeon,Stéphane, AU - Tatoulian,Michael, AU - Mantovani,Diego, PY - 2014/7/3/entrez PY - 2014/7/6/pubmed PY - 2015/2/11/medline SP - 029013 EP - 029013 JF - Biointerphases JO - Biointerphases VL - 9 IS - 2 N2 - Environmental surfaces are increasingly recognized as important sources of transmission of hospital-acquired infections. The use of antibacterial surface coatings may constitute an effective solution to reduce the spread of contamination in healthcare settings, provided that they exhibit sufficient stability and a long-term antibacterial effect. In this study, silver-incorporated diamondlike carbon films (Ag-DLC) were prepared in a continuous, single-step plasma process using a hybrid, inductively coupled plasma reactor combined with a very-low-frequency sputtering setup. The average Ag concentration in the films, ranging from 0 to 2.4 at. %, was controlled by varying the sputtering bias on the silver target. The authors found that the activity of Escherichia coli was reduced by 2.5 orders of magnitude, compared with the control surface, after a 4-h contact with a 2.4 at. % Ag-DLC coating. The coatings displayed slow release kinetics, with a total silver ion release in the sub-ppb range after 4 h in solution, as measured by graphite furnace-atomic absorption spectroscopy. This was confirmed by Kirby-Bauer diffusion tests, which showed limited diffusion of biocidal silver with a localized antibacterial effect. As a slow and continuous release is mandatory to ensure a lasting antibacterial effect, the newly developed Ag-DLC coatings appears as promising materials for environmental hospital surfaces. SN - 1559-4106 UR - https://www.unboundmedicine.com/medline/citation/24985217/On_the_long_term_antibacterial_features_of_silver_doped_diamondlike_carbon_coatings_deposited_via_a_hybrid_plasma_process_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -