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Low mortality of Staphylococcus aureus bacteremia in Icelandic children: nationwide study on incidence and outcome.
Pediatr Infect Dis J 2015; 34(2):140-4PI

Abstract

BACKGROUND

Staphylococcus aureus is a major cause of blood stream infections, but population-based studies on pediatric S. aureus bacteremia (SAB) are sparse. The objective of the study was to evaluate the incidence and mortality of SAB in Icelandic children over time, and to assess the proportions of nosocomial and health-care-associated infections.

METHODS

Children <18 years with positive blood cultures for S. aureus from January 1995 through December 2011 were identified retrospectively at the clinical microbiology laboratories performing blood cultures in Iceland. Clinical data were collected from medical records.

RESULTS

In total, 140 children had 146 distinct episodes of SAB. Bacteremia-related mortality was 0.7% (1/146), all-cause 30-day mortality, 1.4% (2/146), and 1-year mortality, 3.6% (5/140). The annual incidence of SAB was 10.9/100,000 children, decreasing by 36% from 13.1/100,000 in 1995-2003 to 8.4/100,000 in 2004-2011 (P < 0.001). At the same time the annual number of blood cultures analyzed at the main study site decreased from 1529 to 1143 (25%). SAB incidence was highest in infants (<1 year), 58.8/100,000. Of 146 episodes 50 (34%) were nosocomial, 21 (14%) health-care associated and 75 (51%) community acquired. No methicillin-resistant S. aureus isolate was identified.

CONCLUSIONS

In this nationwide study on pediatric SAB, the case fatality ratio was very low. A decreasing incidence was seen, possibly related to fewer blood cultures being collected. Nosocomial and health-care-associated infections accounted for 50% of the cases. The findings provide useful information on the epidemiology and outcome of SAB in children.

Authors+Show Affiliations

From the *Department of Infectious Diseases, Karolinska University Hospital; †Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; ‡Department of Infectious Diseases; §Department of Infection Control; ¶Department of Clinical Microbiology, Landspitali University Hospital, Reykjavík, Iceland; ‖Faculty of Medicine, University of Iceland, Reykjavik, Iceland; **The Children's Hospital Iceland, Landspitali University Hospital, Reykjavík, Iceland; and ††Department of Internal Medicine, Akureyri Hospital, Akureyri, Iceland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24992124

Citation

Asgeirsson, Hilmir, et al. "Low Mortality of Staphylococcus Aureus Bacteremia in Icelandic Children: Nationwide Study On Incidence and Outcome." The Pediatric Infectious Disease Journal, vol. 34, no. 2, 2015, pp. 140-4.
Asgeirsson H, Gudlaugsson O, Kristinsson KG, et al. Low mortality of Staphylococcus aureus bacteremia in Icelandic children: nationwide study on incidence and outcome. Pediatr Infect Dis J. 2015;34(2):140-4.
Asgeirsson, H., Gudlaugsson, O., Kristinsson, K. G., Vilbergsson, G. R., Heiddal, S., Haraldsson, A., ... Kristjansson, M. (2015). Low mortality of Staphylococcus aureus bacteremia in Icelandic children: nationwide study on incidence and outcome. The Pediatric Infectious Disease Journal, 34(2), pp. 140-4. doi:10.1097/INF.0000000000000485.
Asgeirsson H, et al. Low Mortality of Staphylococcus Aureus Bacteremia in Icelandic Children: Nationwide Study On Incidence and Outcome. Pediatr Infect Dis J. 2015;34(2):140-4. PubMed PMID: 24992124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low mortality of Staphylococcus aureus bacteremia in Icelandic children: nationwide study on incidence and outcome. AU - Asgeirsson,Hilmir, AU - Gudlaugsson,Olafur, AU - Kristinsson,Karl G, AU - Vilbergsson,Gauti R, AU - Heiddal,Sigurdur, AU - Haraldsson,Asgeir, AU - Weiland,Ola, AU - Kristjansson,Mar, PY - 2014/7/4/entrez PY - 2014/7/6/pubmed PY - 2015/11/14/medline SP - 140 EP - 4 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 34 IS - 2 N2 - BACKGROUND: Staphylococcus aureus is a major cause of blood stream infections, but population-based studies on pediatric S. aureus bacteremia (SAB) are sparse. The objective of the study was to evaluate the incidence and mortality of SAB in Icelandic children over time, and to assess the proportions of nosocomial and health-care-associated infections. METHODS: Children <18 years with positive blood cultures for S. aureus from January 1995 through December 2011 were identified retrospectively at the clinical microbiology laboratories performing blood cultures in Iceland. Clinical data were collected from medical records. RESULTS: In total, 140 children had 146 distinct episodes of SAB. Bacteremia-related mortality was 0.7% (1/146), all-cause 30-day mortality, 1.4% (2/146), and 1-year mortality, 3.6% (5/140). The annual incidence of SAB was 10.9/100,000 children, decreasing by 36% from 13.1/100,000 in 1995-2003 to 8.4/100,000 in 2004-2011 (P < 0.001). At the same time the annual number of blood cultures analyzed at the main study site decreased from 1529 to 1143 (25%). SAB incidence was highest in infants (<1 year), 58.8/100,000. Of 146 episodes 50 (34%) were nosocomial, 21 (14%) health-care associated and 75 (51%) community acquired. No methicillin-resistant S. aureus isolate was identified. CONCLUSIONS: In this nationwide study on pediatric SAB, the case fatality ratio was very low. A decreasing incidence was seen, possibly related to fewer blood cultures being collected. Nosocomial and health-care-associated infections accounted for 50% of the cases. The findings provide useful information on the epidemiology and outcome of SAB in children. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/24992124/Low_mortality_of_Staphylococcus_aureus_bacteremia_in_Icelandic_children:_nationwide_study_on_incidence_and_outcome_ L2 - http://Insights.ovid.com/pubmed?pmid=24992124 DB - PRIME DP - Unbound Medicine ER -