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The vitamin D status in inflammatory bowel disease.

Abstract

CONTEXT

There is no consensus on the vitamin D status of children and adolescents with inflammatory bowel disease (IBD).

AIM

To determine the vitamin D status of patients with IBD by comparing their serum 25(OH)D concentration to that of healthy controls.

HYPOTHESIS

Serum 25(OH)D concentration will be lower in patients with IBD compared to controls.

SUBJECTS AND METHODS

A case-controlled retrospective study of subjects with IBD (n = 58) of 2-20 years (male n = 31, age 16.38±2.21 years; female n = 27, age 16.56±2.08 years) and healthy controls (n = 116; male n = 49, age 13.90±4.59 years; female n = 67, age 15.04±4.12 years). Study subject inclusion criteria: diagnosis of Crohn's disease (CD) or ulcerative colitis (UC). Vitamin D deficiency was defined as 25(OH)D of (<20 ng/mL) (<50 nmol/L), overweight as BMI of ≥85th but <95th percentile, and obesity as BMI ≥95th percentile. Data were expressed as mean ± SD.

RESULTS

Patients with CD, UC, and their controls had mean serum 25(OH)D concentrations of 61.69±24.43 nmol/L, 53.26±25.51, and 65.32±27.97 respectively (ANOVA, p = 0.196). The overweight/obese controls had significantly lower 25(OH)D concentration compared to the normal-weight controls (p = 0.031); whereas 25(OH)D concentration was similar between the normal-weight and overweight/obese IBD patients (p = 0.883). There was no difference in 25(OH)D between patients with UC and CD, or between subjects with active IBD and controls. However, IBD subjects with elevated ESR had significantly lower 25(OH)D than IBD subjects with normal ESR (p = 0.025), as well as controls (65.3±28.0 nmol/L vs. 49.5±25.23, p = 0.045).

CONCLUSION

There is no difference in mean serum 25(OH)D concentration between children and adolescents with IBD and controls. However, IBD subjects with elevated ESR have significantly lower 25(OH)D than controls. Therefore, IBD subjects with elevated ESR should be monitored for vitamin D deficiency.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

    ,

    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

    ,

    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

    Source

    PloS one 9:7 2014 pg e101583

    MeSH

    Adolescent
    Blood Sedimentation
    Body Height
    Body Mass Index
    Case-Control Studies
    Child
    Child, Preschool
    Cohort Studies
    Colitis, Ulcerative
    Crohn Disease
    Female
    Humans
    Immunoassay
    Inflammatory Bowel Diseases
    Male
    Retrospective Studies
    Severity of Illness Index
    Vitamin D
    Vitamin D Deficiency
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24992465

    Citation

    Veit, Lauren Elizabeth, et al. "The Vitamin D Status in Inflammatory Bowel Disease." PloS One, vol. 9, no. 7, 2014, pp. e101583.
    Veit LE, Maranda L, Fong J, et al. The vitamin D status in inflammatory bowel disease. PLoS ONE. 2014;9(7):e101583.
    Veit, L. E., Maranda, L., Fong, J., & Nwosu, B. U. (2014). The vitamin D status in inflammatory bowel disease. PloS One, 9(7), pp. e101583. doi:10.1371/journal.pone.0101583.
    Veit LE, et al. The Vitamin D Status in Inflammatory Bowel Disease. PLoS ONE. 2014;9(7):e101583. PubMed PMID: 24992465.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The vitamin D status in inflammatory bowel disease. AU - Veit,Lauren Elizabeth, AU - Maranda,Louise, AU - Fong,Jay, AU - Nwosu,Benjamin Udoka, Y1 - 2014/07/03/ PY - 2014/04/06/received PY - 2014/06/06/accepted PY - 2014/7/4/entrez PY - 2014/7/6/pubmed PY - 2015/10/16/medline SP - e101583 EP - e101583 JF - PloS one JO - PLoS ONE VL - 9 IS - 7 N2 - CONTEXT: There is no consensus on the vitamin D status of children and adolescents with inflammatory bowel disease (IBD). AIM: To determine the vitamin D status of patients with IBD by comparing their serum 25(OH)D concentration to that of healthy controls. HYPOTHESIS: Serum 25(OH)D concentration will be lower in patients with IBD compared to controls. SUBJECTS AND METHODS: A case-controlled retrospective study of subjects with IBD (n = 58) of 2-20 years (male n = 31, age 16.38±2.21 years; female n = 27, age 16.56±2.08 years) and healthy controls (n = 116; male n = 49, age 13.90±4.59 years; female n = 67, age 15.04±4.12 years). Study subject inclusion criteria: diagnosis of Crohn's disease (CD) or ulcerative colitis (UC). Vitamin D deficiency was defined as 25(OH)D of (<20 ng/mL) (<50 nmol/L), overweight as BMI of ≥85th but <95th percentile, and obesity as BMI ≥95th percentile. Data were expressed as mean ± SD. RESULTS: Patients with CD, UC, and their controls had mean serum 25(OH)D concentrations of 61.69±24.43 nmol/L, 53.26±25.51, and 65.32±27.97 respectively (ANOVA, p = 0.196). The overweight/obese controls had significantly lower 25(OH)D concentration compared to the normal-weight controls (p = 0.031); whereas 25(OH)D concentration was similar between the normal-weight and overweight/obese IBD patients (p = 0.883). There was no difference in 25(OH)D between patients with UC and CD, or between subjects with active IBD and controls. However, IBD subjects with elevated ESR had significantly lower 25(OH)D than IBD subjects with normal ESR (p = 0.025), as well as controls (65.3±28.0 nmol/L vs. 49.5±25.23, p = 0.045). CONCLUSION: There is no difference in mean serum 25(OH)D concentration between children and adolescents with IBD and controls. However, IBD subjects with elevated ESR have significantly lower 25(OH)D than controls. Therefore, IBD subjects with elevated ESR should be monitored for vitamin D deficiency. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24992465/The_vitamin_D_status_in_inflammatory_bowel_disease_ L2 - http://dx.plos.org/10.1371/journal.pone.0101583 DB - PRIME DP - Unbound Medicine ER -