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Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation.
Exp Brain Res 2014; 232(10):3345-51EB

Abstract

The capacity for transcranial direct current stimulation (tDCS) to increase learning and cognition shows promise for the development of enhanced therapeutic interventions. One potential application is the combination of tDCS with cognitive training (CT), a psychological intervention which aims to improve targeted cognitive abilities. We have previously shown that tDCS enhanced performance accuracy, but not skill acquisition, on a dual n-back working memory (WM) CT task over repeated sessions. In the current study, we investigated the optimal timing for combining tDCS with the same CT task to enhance within and between session performance outcomes across two daily CT sessions. Twenty healthy participants received in a randomised order 30 min of anodal tDCS to the left dorsolateral prefrontal cortex immediately before ('offline' tDCS) and during performance ('online' tDCS) on a dual n-back WM CT task, in an intra-individual crossover design. Analyses examined within and between session consolidation effects of tDCS on CT performance outcomes. Results showed that 'online' tDCS was associated with better within session skill acquisition on the CT task, with a significant difference found between conditions the following day. These results suggest that 'online' tDCS is superior to 'offline' tDCS for enhancing skill acquisition when combining anodal tDCS with CT. This finding may assist with the development of enhanced protocols involving the combination of tDCS with CT and other rehabilitation protocols.

Authors+Show Affiliations

Black Dog Institute, School of Psychiatry, Prince of Wales Hospital, University of New South Wales, Barker St, Randwick, Sydney, 2031, Australia, donel.martin@unsw.edu.au.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24992897

Citation

Martin, Donel M., et al. "Use of Transcranial Direct Current Stimulation (tDCS) to Enhance Cognitive Training: Effect of Timing of Stimulation." Experimental Brain Research, vol. 232, no. 10, 2014, pp. 3345-51.
Martin DM, Liu R, Alonzo A, et al. Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation. Exp Brain Res. 2014;232(10):3345-51.
Martin, D. M., Liu, R., Alonzo, A., Green, M., & Loo, C. K. (2014). Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation. Experimental Brain Research, 232(10), pp. 3345-51. doi:10.1007/s00221-014-4022-x.
Martin DM, et al. Use of Transcranial Direct Current Stimulation (tDCS) to Enhance Cognitive Training: Effect of Timing of Stimulation. Exp Brain Res. 2014;232(10):3345-51. PubMed PMID: 24992897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation. AU - Martin,Donel M, AU - Liu,Rose, AU - Alonzo,Angelo, AU - Green,Melissa, AU - Loo,Colleen K, Y1 - 2014/07/04/ PY - 2014/03/05/received PY - 2014/06/17/accepted PY - 2014/7/5/entrez PY - 2014/7/6/pubmed PY - 2015/8/15/medline SP - 3345 EP - 51 JF - Experimental brain research JO - Exp Brain Res VL - 232 IS - 10 N2 - The capacity for transcranial direct current stimulation (tDCS) to increase learning and cognition shows promise for the development of enhanced therapeutic interventions. One potential application is the combination of tDCS with cognitive training (CT), a psychological intervention which aims to improve targeted cognitive abilities. We have previously shown that tDCS enhanced performance accuracy, but not skill acquisition, on a dual n-back working memory (WM) CT task over repeated sessions. In the current study, we investigated the optimal timing for combining tDCS with the same CT task to enhance within and between session performance outcomes across two daily CT sessions. Twenty healthy participants received in a randomised order 30 min of anodal tDCS to the left dorsolateral prefrontal cortex immediately before ('offline' tDCS) and during performance ('online' tDCS) on a dual n-back WM CT task, in an intra-individual crossover design. Analyses examined within and between session consolidation effects of tDCS on CT performance outcomes. Results showed that 'online' tDCS was associated with better within session skill acquisition on the CT task, with a significant difference found between conditions the following day. These results suggest that 'online' tDCS is superior to 'offline' tDCS for enhancing skill acquisition when combining anodal tDCS with CT. This finding may assist with the development of enhanced protocols involving the combination of tDCS with CT and other rehabilitation protocols. SN - 1432-1106 UR - https://www.unboundmedicine.com/medline/citation/24992897/Use_of_transcranial_direct_current_stimulation__tDCS__to_enhance_cognitive_training:_effect_of_timing_of_stimulation_ L2 - https://dx.doi.org/10.1007/s00221-014-4022-x DB - PRIME DP - Unbound Medicine ER -