Tags

Type your tag names separated by a space and hit enter

Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance.
Hum Pathol. 2014 Sep; 45(9):1805-12.HP

Abstract

We have recently shown seminal vesicle intraepithelial involvement of prostate cancer in cases with seminal vesicle invasion (pT3b). Based on the manner of seminal vesicle invasion, there could be 2 possible mechanisms of seminal vesicle intraepithelial involvement: direct intraepithelial invasion from prostate carcinoma in the muscular wall of seminal vesicles or intraepithelial involvement of cancer from the invaginated extraprostatic space (IES)/ejaculatory duct system to extraprostatic seminal vesicle. We aimed to clarify the manner and clinicopathological significance of seminal vesicle intraepithelial involvement. Of 1629 consecutive radical prostatectomies, 109 cases (6.7%) showed seminal vesicle invasion in whole-mounted radical prostatectomy specimens. In these pT3b cases, 18 (17%) showed seminal vesicle intraepithelial involvement by prostate cancer. Stromal invasion of the IES/ejaculatory duct system and ejaculatory duct intraepithelial invasion by prostate cancer were identified in 62 and 5 of 109 pT3b cases, respectively. However, the presence/absence of IES/ejaculatory duct system involvement by prostate cancer does not predict seminal vesicle intraepithelial involvement. No statistically significant correlation was observed between all pathologic parameters/biochemical recurrence and the presence/absence of seminal vesicle intra-epithelial involvement in the pT3b cases. These findings suggest that seminal vesicle intraepithelial involvement is more likely due to direct invasion of carcinoma from the muscular wall of seminal vesicles rather than intraepithelial extension from the ejaculatory duct system in the IES. Further studies with a substantially greater case number are needed to clarify the clinicopathological significance of seminal vesicle intraepithelial involvement in a better manner.

Authors+Show Affiliations

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX.Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX.Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX.Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; Weill Cornell Medical College of Cornell University, Houston, TX.Department of Urology, Houston Methodist Hospital, Houston, TX.Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; Weill Cornell Medical College of Cornell University, Houston, TX.Department of Pathology Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; Weill Cornell Medical College of Cornell University, Houston, TX. Electronic address: jaero@houstonmethodist.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24993314

Citation

Miyai, Kosuke, et al. "Seminal Vesicle Intraepithelial Involvement By Prostate Cancer: Putative Mechanism and Clinicopathological Significance." Human Pathology, vol. 45, no. 9, 2014, pp. 1805-12.
Miyai K, Kristiansen A, Egevad L, et al. Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance. Hum Pathol. 2014;45(9):1805-12.
Miyai, K., Kristiansen, A., Egevad, L., Pina-Oviedo, S., Divatia, M. K., Shen, S. S., Miles, B. J., Ayala, A. G., Park, Y. W., & Ro, J. Y. (2014). Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance. Human Pathology, 45(9), 1805-12. https://doi.org/10.1016/j.humpath.2014.05.004
Miyai K, et al. Seminal Vesicle Intraepithelial Involvement By Prostate Cancer: Putative Mechanism and Clinicopathological Significance. Hum Pathol. 2014;45(9):1805-12. PubMed PMID: 24993314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance. AU - Miyai,Kosuke, AU - Kristiansen,Anna, AU - Egevad,Lars, AU - Pina-Oviedo,Sergio, AU - Divatia,Mukul K, AU - Shen,Steven S, AU - Miles,Brian J, AU - Ayala,Alberto G, AU - Park,Yong Wook, AU - Ro,Jae Y, Y1 - 2014/05/23/ PY - 2014/03/21/received PY - 2014/05/05/revised PY - 2014/05/07/accepted PY - 2014/7/5/entrez PY - 2014/7/6/pubmed PY - 2014/11/13/medline KW - Intraepithelial involvement KW - Pathogenesis KW - Prostate KW - Prostate cancer KW - Seminal vesicle invasion SP - 1805 EP - 12 JF - Human pathology JO - Hum Pathol VL - 45 IS - 9 N2 - We have recently shown seminal vesicle intraepithelial involvement of prostate cancer in cases with seminal vesicle invasion (pT3b). Based on the manner of seminal vesicle invasion, there could be 2 possible mechanisms of seminal vesicle intraepithelial involvement: direct intraepithelial invasion from prostate carcinoma in the muscular wall of seminal vesicles or intraepithelial involvement of cancer from the invaginated extraprostatic space (IES)/ejaculatory duct system to extraprostatic seminal vesicle. We aimed to clarify the manner and clinicopathological significance of seminal vesicle intraepithelial involvement. Of 1629 consecutive radical prostatectomies, 109 cases (6.7%) showed seminal vesicle invasion in whole-mounted radical prostatectomy specimens. In these pT3b cases, 18 (17%) showed seminal vesicle intraepithelial involvement by prostate cancer. Stromal invasion of the IES/ejaculatory duct system and ejaculatory duct intraepithelial invasion by prostate cancer were identified in 62 and 5 of 109 pT3b cases, respectively. However, the presence/absence of IES/ejaculatory duct system involvement by prostate cancer does not predict seminal vesicle intraepithelial involvement. No statistically significant correlation was observed between all pathologic parameters/biochemical recurrence and the presence/absence of seminal vesicle intra-epithelial involvement in the pT3b cases. These findings suggest that seminal vesicle intraepithelial involvement is more likely due to direct invasion of carcinoma from the muscular wall of seminal vesicles rather than intraepithelial extension from the ejaculatory duct system in the IES. Further studies with a substantially greater case number are needed to clarify the clinicopathological significance of seminal vesicle intraepithelial involvement in a better manner. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/24993314/Seminal_vesicle_intraepithelial_involvement_by_prostate_cancer:_putative_mechanism_and_clinicopathological_significance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(14)00208-1 DB - PRIME DP - Unbound Medicine ER -