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Clinical features of human papilloma virus-related head and neck squamous cell carcinoma of an unknown primary site.
ORL J Otorhinolaryngol Relat Spec. 2014; 76(3):137-46.OJ

Abstract

PURPOSE

Head and neck squamous cell carcinoma of an unknown primary site (HNSCCUP) is a heterogeneous group of tumors that includes the human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. To investigate the relationship between HNSCCUP and HPV, we reviewed p16 overexpression and HPV DNA in lymph node metastases and examined their correlation with the primary site and clinical features.

MATERIALS AND METHODS

Thirty-three patients with HNSCCUP were retrospectively studied. Dissected neck metastases were analyzed for p16 overexpression by immunohistochemistry, and the presence of HPV DNA was investigated by in situ hybridization.

RESULTS

Of the 33 patients, 8 (24%) exhibited p16 overexpression. p16-positive lymph node metastases contained significantly more HPV DNA and were most frequently associated with occult primary lesions in the oropharynx and a favorable prognosis. Patients with a lower alcohol consumption, only level II/III metastasis, and cystic lymph node metastasis tended to have p16 overexpression.

CONCLUSIONS

This is the first report on the relationship of HNSCCUP with p16 and HPV DNA status in Asian patients. In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in neck metastasis was predictive of both an occult primary lesion in the oropharynx and an association with HPV infection. Alcohol consumption, location, and features of neck metastasis were correlated with p16 expression.

Authors+Show Affiliations

Department of Otolaryngology, Head and Neck Surgery, The University of Tokyo Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24993345

Citation

Kobayashi, Kenya, et al. "Clinical Features of Human Papilloma Virus-related Head and Neck Squamous Cell Carcinoma of an Unknown Primary Site." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 76, no. 3, 2014, pp. 137-46.
Kobayashi K, Saito Y, Omura G, et al. Clinical features of human papilloma virus-related head and neck squamous cell carcinoma of an unknown primary site. ORL J Otorhinolaryngol Relat Spec. 2014;76(3):137-46.
Kobayashi, K., Saito, Y., Omura, G., Ando, M., Sakamoto, T., Yamasoba, T., & Asakage, T. (2014). Clinical features of human papilloma virus-related head and neck squamous cell carcinoma of an unknown primary site. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 76(3), 137-46. https://doi.org/10.1159/000363190
Kobayashi K, et al. Clinical Features of Human Papilloma Virus-related Head and Neck Squamous Cell Carcinoma of an Unknown Primary Site. ORL J Otorhinolaryngol Relat Spec. 2014;76(3):137-46. PubMed PMID: 24993345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of human papilloma virus-related head and neck squamous cell carcinoma of an unknown primary site. AU - Kobayashi,Kenya, AU - Saito,Yuki, AU - Omura,Go, AU - Ando,Mizuo, AU - Sakamoto,Takashi, AU - Yamasoba,Tatsuya, AU - Asakage,Takahiro, Y1 - 2014/07/02/ PY - 2014/02/03/received PY - 2014/04/24/accepted PY - 2014/7/5/entrez PY - 2014/7/6/pubmed PY - 2015/5/23/medline SP - 137 EP - 46 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 76 IS - 3 N2 - PURPOSE: Head and neck squamous cell carcinoma of an unknown primary site (HNSCCUP) is a heterogeneous group of tumors that includes the human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. To investigate the relationship between HNSCCUP and HPV, we reviewed p16 overexpression and HPV DNA in lymph node metastases and examined their correlation with the primary site and clinical features. MATERIALS AND METHODS: Thirty-three patients with HNSCCUP were retrospectively studied. Dissected neck metastases were analyzed for p16 overexpression by immunohistochemistry, and the presence of HPV DNA was investigated by in situ hybridization. RESULTS: Of the 33 patients, 8 (24%) exhibited p16 overexpression. p16-positive lymph node metastases contained significantly more HPV DNA and were most frequently associated with occult primary lesions in the oropharynx and a favorable prognosis. Patients with a lower alcohol consumption, only level II/III metastasis, and cystic lymph node metastasis tended to have p16 overexpression. CONCLUSIONS: This is the first report on the relationship of HNSCCUP with p16 and HPV DNA status in Asian patients. In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in neck metastasis was predictive of both an occult primary lesion in the oropharynx and an association with HPV infection. Alcohol consumption, location, and features of neck metastasis were correlated with p16 expression. SN - 1423-0275 UR - https://www.unboundmedicine.com/medline/citation/24993345/Clinical_features_of_human_papilloma_virus_related_head_and_neck_squamous_cell_carcinoma_of_an_unknown_primary_site_ L2 - https://www.karger.com?DOI=10.1159/000363190 DB - PRIME DP - Unbound Medicine ER -