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The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): rationale, study design, and cohort description.
Neuroepidemiology. 2014; 43(1):9-14.N

Abstract

BACKGROUND

Accumulating epidemiological evidence from several populations supports the important role of the Mediterranean-type diet (MeDi) in reducing the risk for age-related diseases such as Alzheimer's disease (AD). However, the relevant literature is clearly deficient for most Mediterranean countries that more closely adhere to the originally described MeDi. Greece resides in the Mediterranean basin, and older generations traditionally adhere to a MeDi.

METHODS

We here present the design and the preliminary baseline characteristics of the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). The HELIAD is a population-based, multidisciplinary, collaborative study designed to estimate the prevalence and incidence of AD, other dementias, mild cognitive impairment, and other neuropsychiatric conditions of aging in the Greek population and to investigate associations between nutrition and cognitive dysfunction/age-related neuropsychiatric diseases in this Mediterranean population. The study also ascertains several demographic, medical, social, environmental, clinical, nutritional, and neuropsychological determinants and lifestyle activities.

RESULTS

In total, 1,050 participants of a random sample have already completed the initial evaluation. The subjects were, on average, 73.4 (SD = 6.0) years old, 60% of the sample were female, and most of the participants were poorly educated with an average of 5.41 (SD = 3.5) years of education. The performance on the neuropsychological tests was equivalent to the average scores of previous normative Greek samples. More than one third of the population under investigation was considered to be at high risk for malnutrition.

CONCLUSIONS

The HELIAD may provide important data for expanding our knowledge regarding the prevalence, incidence, and risk factors of AD and several other neuropsychiatric diseases in the Mediterranean region.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Dardiotis E
Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Kosmidis MH
No affiliation info available
Yannakoulia M
No affiliation info available
Hadjigeorgiou GM
No affiliation info available
Scarmeas N
No affiliation info available

MeSH

AgedAged, 80 and overAgingAlzheimer DiseaseDiet, MediterraneanFemaleGreeceHumansLongitudinal StudiesMaleNeuropsychological TestsResearch DesignRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24993387

Citation

Dardiotis, Efthimios, et al. "The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, Study Design, and Cohort Description." Neuroepidemiology, vol. 43, no. 1, 2014, pp. 9-14.
Dardiotis E, Kosmidis MH, Yannakoulia M, et al. The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): rationale, study design, and cohort description. Neuroepidemiology. 2014;43(1):9-14.
Dardiotis, E., Kosmidis, M. H., Yannakoulia, M., Hadjigeorgiou, G. M., & Scarmeas, N. (2014). The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): rationale, study design, and cohort description. Neuroepidemiology, 43(1), 9-14. https://doi.org/10.1159/000362723
Dardiotis E, et al. The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, Study Design, and Cohort Description. Neuroepidemiology. 2014;43(1):9-14. PubMed PMID: 24993387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): rationale, study design, and cohort description. AU - Dardiotis,Efthimios, AU - Kosmidis,Mary H, AU - Yannakoulia,Mary, AU - Hadjigeorgiou,Georgios M, AU - Scarmeas,Nikolaos, Y1 - 2014/07/02/ PY - 2013/12/03/received PY - 2014/04/08/accepted PY - 2014/7/5/entrez PY - 2014/7/6/pubmed PY - 2015/7/8/medline SP - 9 EP - 14 JF - Neuroepidemiology JO - Neuroepidemiology VL - 43 IS - 1 N2 - BACKGROUND: Accumulating epidemiological evidence from several populations supports the important role of the Mediterranean-type diet (MeDi) in reducing the risk for age-related diseases such as Alzheimer's disease (AD). However, the relevant literature is clearly deficient for most Mediterranean countries that more closely adhere to the originally described MeDi. Greece resides in the Mediterranean basin, and older generations traditionally adhere to a MeDi. METHODS: We here present the design and the preliminary baseline characteristics of the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). The HELIAD is a population-based, multidisciplinary, collaborative study designed to estimate the prevalence and incidence of AD, other dementias, mild cognitive impairment, and other neuropsychiatric conditions of aging in the Greek population and to investigate associations between nutrition and cognitive dysfunction/age-related neuropsychiatric diseases in this Mediterranean population. The study also ascertains several demographic, medical, social, environmental, clinical, nutritional, and neuropsychological determinants and lifestyle activities. RESULTS: In total, 1,050 participants of a random sample have already completed the initial evaluation. The subjects were, on average, 73.4 (SD = 6.0) years old, 60% of the sample were female, and most of the participants were poorly educated with an average of 5.41 (SD = 3.5) years of education. The performance on the neuropsychological tests was equivalent to the average scores of previous normative Greek samples. More than one third of the population under investigation was considered to be at high risk for malnutrition. CONCLUSIONS: The HELIAD may provide important data for expanding our knowledge regarding the prevalence, incidence, and risk factors of AD and several other neuropsychiatric diseases in the Mediterranean region. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/24993387/The_Hellenic_Longitudinal_Investigation_of_Aging_and_Diet__HELIAD_:_rationale_study_design_and_cohort_description_ DB - PRIME DP - Unbound Medicine ER -