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Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD.
J Atten Disord 2017; 21(6):487-493JA

Abstract

OBJECTIVE

In our study, we aimed to evaluate the plasma homocysteine levels and oxidative stress parameters in patients with adult ADHD (A-ADHD).

METHOD

Blood samples were taken from 32 A-ADHD patients and 32 controls enrolled in the study and plasma homocysteine, serum folate, vitamin B12, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined. Results were compared between the groups.

RESULTS

Patients' plasma homocysteine level was significantly lower and serum folate level was significantly higher than the controls. The means of plasma homocysteine and folate levels were statistically significantly different between the groups (p < .05). However, a statistically significant difference was not detected between groups for mean serum vitamin B12, TAS, TOS, and OSI levels (p > .05).

CONCLUSION

Our study suggests that oxidative balance is not impaired in A-ADHD, and contrary to other psychiatric disorders, homocysteine levels were found to be lower.

Authors+Show Affiliations

1 Harran University, Sanliurfa, Turkey.2 Antalya Training and Research Hospital, Turkey.3 Bezmialem Vakif University, İstanbul, Turkey.4 Mevlana University, Konya, Turkey.5 Konya Training and Research Hospital, Turkey.1 Harran University, Sanliurfa, Turkey.1 Harran University, Sanliurfa, Turkey.1 Harran University, Sanliurfa, Turkey.1 Harran University, Sanliurfa, Turkey.1 Harran University, Sanliurfa, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24994877

Citation

Karababa, İbrahim Fatih, et al. "Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD." Journal of Attention Disorders, vol. 21, no. 6, 2017, pp. 487-493.
Karababa İF, Savas SN, Selek S, et al. Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD. J Atten Disord. 2017;21(6):487-493.
Karababa, İ. F., Savas, S. N., Selek, S., Cicek, E., Cicek, E. I., Asoglu, M., ... Ulas, T. (2017). Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD. Journal of Attention Disorders, 21(6), pp. 487-493. doi:10.1177/1087054714538657.
Karababa İF, et al. Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD. J Atten Disord. 2017;21(6):487-493. PubMed PMID: 24994877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD. AU - Karababa,İbrahim Fatih, AU - Savas,Sermin Nur, AU - Selek,Sehabettin, AU - Cicek,Erdinc, AU - Cicek,Esra Ismet, AU - Asoglu,Mehmet, AU - Bayazit,Huseyin, AU - Kandemir,Hasan, AU - Kati,Mahmut, AU - Ulas,Turgay, Y1 - 2016/07/27/ PY - 2014/7/6/pubmed PY - 2017/12/19/medline PY - 2014/7/5/entrez KW - adult ADHD KW - homocysteine KW - oxidative status SP - 487 EP - 493 JF - Journal of attention disorders JO - J Atten Disord VL - 21 IS - 6 N2 - OBJECTIVE: In our study, we aimed to evaluate the plasma homocysteine levels and oxidative stress parameters in patients with adult ADHD (A-ADHD). METHOD: Blood samples were taken from 32 A-ADHD patients and 32 controls enrolled in the study and plasma homocysteine, serum folate, vitamin B12, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined. Results were compared between the groups. RESULTS: Patients' plasma homocysteine level was significantly lower and serum folate level was significantly higher than the controls. The means of plasma homocysteine and folate levels were statistically significantly different between the groups (p < .05). However, a statistically significant difference was not detected between groups for mean serum vitamin B12, TAS, TOS, and OSI levels (p > .05). CONCLUSION: Our study suggests that oxidative balance is not impaired in A-ADHD, and contrary to other psychiatric disorders, homocysteine levels were found to be lower. SN - 1557-1246 UR - https://www.unboundmedicine.com/medline/citation/24994877/Homocysteine_Levels_and_Oxidative_Stress_Parameters_in_Patients_With_Adult_ADHD_ L2 - http://journals.sagepub.com/doi/full/10.1177/1087054714538657?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -