Tags

Type your tag names separated by a space and hit enter

The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.
Brain Pathol. 2015 Mar; 25(2):121-35.BP

Abstract

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are among the human synucleinopathies, which show alpha-synuclein immunoreactive neuronal and/or glial aggregations and progressive neuronal loss in selected brain regions (eg, substantia nigra, ventral tegmental area, pedunculopontine nucleus). Despite several studies about brainstem pathologies in PD and DLB, there is currently no detailed information available regarding the presence of alpha-synuclein immunoreactive inclusions (i) in the cranial nerve, precerebellar, vestibular and oculomotor brainstem nuclei and (ii) in brainstem fiber tracts and oligodendroctyes. Therefore, we analyzed the inclusion pathologies in the brainstem nuclei (Lewy bodies, LB; Lewy neurites, LN; coiled bodies, CB) and fiber tracts (LN, CB) of PD and DLB patients. As reported in previous studies, LB and LN were most prevalent in the substantia nigra, ventral tegmental area, pedunculopontine and raphe nuclei, periaqueductal gray, locus coeruleus, parabrachial nuclei, reticular formation, prepositus hypoglossal, dorsal motor vagal and solitary nuclei. Additionally we were able to demonstrate LB and LN in all cranial nerve nuclei, premotor oculomotor, precerebellar and vestibular brainstem nuclei, as well as LN in all brainstem fiber tracts. CB were present in nearly all brainstem nuclei and brainstem fiber tracts containing LB and/or LN. These findings can contribute to a large variety of less well-explained PD and DLB symptoms (eg, gait and postural instability, impaired balance and postural reflexes, falls, ingestive and oculomotor dysfunctions) and point to the occurrence of disturbances of intra-axonal transport processes and transneuronal spread of the underlying pathological processes of PD and DLB along anatomical pathways.

Links

PMC Free PDF

Authors+Show Affiliations

Seidel K
Dr. Senckenbergisches Chronomedizinisches Institute, J.W. Goethe University, Frankfurt/Main, Germany.
Mahlke J
No affiliation info available
Siswanto S
No affiliation info available
Krüger R
No affiliation info available
Heinsen H
No affiliation info available
Auburger G
No affiliation info available
Bouzrou M
No affiliation info available
Grinberg LT
No affiliation info available
Wicht H
No affiliation info available
Korf HW
No affiliation info available
den Dunnen W
No affiliation info available
Rüb U
No affiliation info available

MeSH

AgedAged, 80 and overBrain StemCoiled BodiesFemaleHumansLewy BodiesLewy Body DiseaseMaleMiddle AgedNeuronsOligodendrogliaParkinson Diseasealpha-Synuclein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24995389

Citation

Seidel, Kay, et al. "The Brainstem Pathologies of Parkinson's Disease and Dementia With Lewy Bodies." Brain Pathology (Zurich, Switzerland), vol. 25, no. 2, 2015, pp. 121-35.
Seidel K, Mahlke J, Siswanto S, et al. The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. Brain Pathol. 2015;25(2):121-35.
Seidel, K., Mahlke, J., Siswanto, S., Krüger, R., Heinsen, H., Auburger, G., Bouzrou, M., Grinberg, L. T., Wicht, H., Korf, H. W., den Dunnen, W., & Rüb, U. (2015). The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. Brain Pathology (Zurich, Switzerland), 25(2), 121-35. https://doi.org/10.1111/bpa.12168
Seidel K, et al. The Brainstem Pathologies of Parkinson's Disease and Dementia With Lewy Bodies. Brain Pathol. 2015;25(2):121-35. PubMed PMID: 24995389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. AU - Seidel,Kay, AU - Mahlke,Josefine, AU - Siswanto,Sonny, AU - Krüger,Reijko, AU - Heinsen,Helmut, AU - Auburger,Georg, AU - Bouzrou,Mohamed, AU - Grinberg,Lea T, AU - Wicht,Helmut, AU - Korf,Horst-Werner, AU - den Dunnen,Wilfred, AU - Rüb,Udo, Y1 - 2014/09/12/ PY - 2014/4/29/received PY - 2014/6/22/accepted PY - 2014/7/5/entrez PY - 2014/7/6/pubmed PY - 2015/10/23/medline KW - Parkinson's disease KW - alpha-synuclein KW - brainstem KW - dementia with Lewy bodies KW - prion-like disease SP - 121 EP - 35 JF - Brain pathology (Zurich, Switzerland) JO - Brain Pathol VL - 25 IS - 2 N2 - Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are among the human synucleinopathies, which show alpha-synuclein immunoreactive neuronal and/or glial aggregations and progressive neuronal loss in selected brain regions (eg, substantia nigra, ventral tegmental area, pedunculopontine nucleus). Despite several studies about brainstem pathologies in PD and DLB, there is currently no detailed information available regarding the presence of alpha-synuclein immunoreactive inclusions (i) in the cranial nerve, precerebellar, vestibular and oculomotor brainstem nuclei and (ii) in brainstem fiber tracts and oligodendroctyes. Therefore, we analyzed the inclusion pathologies in the brainstem nuclei (Lewy bodies, LB; Lewy neurites, LN; coiled bodies, CB) and fiber tracts (LN, CB) of PD and DLB patients. As reported in previous studies, LB and LN were most prevalent in the substantia nigra, ventral tegmental area, pedunculopontine and raphe nuclei, periaqueductal gray, locus coeruleus, parabrachial nuclei, reticular formation, prepositus hypoglossal, dorsal motor vagal and solitary nuclei. Additionally we were able to demonstrate LB and LN in all cranial nerve nuclei, premotor oculomotor, precerebellar and vestibular brainstem nuclei, as well as LN in all brainstem fiber tracts. CB were present in nearly all brainstem nuclei and brainstem fiber tracts containing LB and/or LN. These findings can contribute to a large variety of less well-explained PD and DLB symptoms (eg, gait and postural instability, impaired balance and postural reflexes, falls, ingestive and oculomotor dysfunctions) and point to the occurrence of disturbances of intra-axonal transport processes and transneuronal spread of the underlying pathological processes of PD and DLB along anatomical pathways. SN - 1750-3639 UR - https://www.unboundmedicine.com/medline/citation/24995389/The_brainstem_pathologies_of_Parkinson's_disease_and_dementia_with_Lewy_bodies_ DB - PRIME DP - Unbound Medicine ER -