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Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness.
Respirology. 2014 Oct; 19(7):1046-51.R

Abstract

BACKGROUND AND OBJECTIVE

Ventilation heterogeneity (VH) has been linked to airway responsiveness (AR) based on various measures of VH involving inert gas washout, forced oscillation and lung imaging. We explore whether VH at baseline, as measured by the simple ratio of single breath alveolar volume to plethysmographically determined total lung capacity (VA/TLC), would correlate with AR as measured by methacholine challenge testing.

METHODS

We analysed data from spirometry, lung volumes, diffusing capacity and methacholine challenge to derive the VA/TLC and the dose-response slope (DRS) of forced expiratory volume in 1 s (DRS-FEV1) during methacholine challenge from 136 patients. We separated out airway closure versus narrowing by examining the DRS for forced vital capacity (DRS-FVC) and the DRS for FEV1/FVC (DRS-FEV1/FVC), respectively. Similarly, we calculated the DRS for sGaw (DRS-sGaw) as another measure of airway narrowing. We performed statistical analysis using Spearman rank correlation and multifactor linear regression using a backward stepwise modelling procedure.

RESULTS

We found that the DRS-FEV1 correlated with baseline VA/TLC (rho = -0.26, P < 0.01), and VA/TLC and FEV1 were independently associated with DRS-FEV1 (R(2) = 0.14, P = 0.01). In addition, VA/TLC was associated with both airway narrowing and closure in response to methacholine.

CONCLUSIONS

These results confirm that baseline VA/TLC is associated with AR, and reflects both airway closure and airway narrowing following methacholine challenge.

Authors+Show Affiliations

Vermont Lung Center, Pulmonary Disease and Critical Care Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24995907

Citation

Kaminsky, David A., et al. "Relationship Between the Baseline Alveolar Volume-to-total Lung Capacity Ratio and Airway Responsiveness." Respirology (Carlton, Vic.), vol. 19, no. 7, 2014, pp. 1046-51.
Kaminsky DA, Daud A, Chapman DG. Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness. Respirology. 2014;19(7):1046-51.
Kaminsky, D. A., Daud, A., & Chapman, D. G. (2014). Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness. Respirology (Carlton, Vic.), 19(7), 1046-51. https://doi.org/10.1111/resp.12347
Kaminsky DA, Daud A, Chapman DG. Relationship Between the Baseline Alveolar Volume-to-total Lung Capacity Ratio and Airway Responsiveness. Respirology. 2014;19(7):1046-51. PubMed PMID: 24995907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness. AU - Kaminsky,David A, AU - Daud,Anees, AU - Chapman,David G, Y1 - 2014/07/03/ PY - 2014/01/22/received PY - 2014/02/27/revised PY - 2014/04/25/revised PY - 2014/05/22/accepted PY - 2014/7/5/entrez PY - 2014/7/6/pubmed PY - 2015/6/5/medline KW - asthma KW - clinical respiratory medicine KW - respiratory function test KW - respiratory mechanics KW - respiratory structure and function SP - 1046 EP - 51 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 19 IS - 7 N2 - BACKGROUND AND OBJECTIVE: Ventilation heterogeneity (VH) has been linked to airway responsiveness (AR) based on various measures of VH involving inert gas washout, forced oscillation and lung imaging. We explore whether VH at baseline, as measured by the simple ratio of single breath alveolar volume to plethysmographically determined total lung capacity (VA/TLC), would correlate with AR as measured by methacholine challenge testing. METHODS: We analysed data from spirometry, lung volumes, diffusing capacity and methacholine challenge to derive the VA/TLC and the dose-response slope (DRS) of forced expiratory volume in 1 s (DRS-FEV1) during methacholine challenge from 136 patients. We separated out airway closure versus narrowing by examining the DRS for forced vital capacity (DRS-FVC) and the DRS for FEV1/FVC (DRS-FEV1/FVC), respectively. Similarly, we calculated the DRS for sGaw (DRS-sGaw) as another measure of airway narrowing. We performed statistical analysis using Spearman rank correlation and multifactor linear regression using a backward stepwise modelling procedure. RESULTS: We found that the DRS-FEV1 correlated with baseline VA/TLC (rho = -0.26, P < 0.01), and VA/TLC and FEV1 were independently associated with DRS-FEV1 (R(2) = 0.14, P = 0.01). In addition, VA/TLC was associated with both airway narrowing and closure in response to methacholine. CONCLUSIONS: These results confirm that baseline VA/TLC is associated with AR, and reflects both airway closure and airway narrowing following methacholine challenge. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/24995907/Relationship_between_the_baseline_alveolar_volume_to_total_lung_capacity_ratio_and_airway_responsiveness_ L2 - https://doi.org/10.1111/resp.12347 DB - PRIME DP - Unbound Medicine ER -