Tags

Type your tag names separated by a space and hit enter

First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany.
J Clin Virol. 2014 Sep; 61(1):170-2.JC

Abstract

Hepatitis E is usually a self-limiting disease and an important cause of acute hepatitis in endemic countries in Asia and Africa. However, the mortality rate for pregnant women infected with hepatitis E virus (HEV) in this area is about 25%. In Germany, sporadic cases of acute hepatitis E infections have been described and the number of autochthonous infections is increasing. Here we report an autochthonous HEV subgenotype 3c infection in a 27-year old pregnant woman. This is the first documented case of a hepatitis E infection during pregnancy in Germany. The patient presented in week 26 of gestation with acute hepatitis and elevated transaminases. During follow-up, she tested positive for anti-HEV antibodies. HEV viral load during the acute hepatitis was 2.3×10(6) copies/ml serum, however viremia declined and cleared rapidly. Sequence analysis revealed a HEV subgenotype 3c closely related to European isolates. The patient had not travelled outside Germany, had regular contact to animals, but the source of infection remains unclear. The newborn was delivered in week 40 of gestation in good health, HEV was not transmitted and liver enzymes were normal. In conclusion, hepatitis E should be considered in differential diagnosis in patients with acute hepatitis especially during pregnancy, even without travel history to countries with high endemicity.

Authors+Show Affiliations

Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.Institute of Clinical Microbiology and Hygiene, Regensburg University Medical Center, Regensburg, Germany.Department of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany.Schwetzinger Str. 51, Heidelberg, Germany.Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany. Electronic address: Paul_Schnitzler@med.uni-heidelberg.de.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24996764

Citation

Tabatabai, J, et al. "First Case Report of an Acute Hepatitis E Subgenotype 3c Infection During Pregnancy in Germany." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 61, no. 1, 2014, pp. 170-2.
Tabatabai J, Wenzel JJ, Soboletzki M, et al. First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany. J Clin Virol. 2014;61(1):170-2.
Tabatabai, J., Wenzel, J. J., Soboletzki, M., Flux, C., Navid, M. H., & Schnitzler, P. (2014). First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 61(1), 170-2. https://doi.org/10.1016/j.jcv.2014.06.008
Tabatabai J, et al. First Case Report of an Acute Hepatitis E Subgenotype 3c Infection During Pregnancy in Germany. J Clin Virol. 2014;61(1):170-2. PubMed PMID: 24996764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany. AU - Tabatabai,J, AU - Wenzel,J J, AU - Soboletzki,M, AU - Flux,C, AU - Navid,M Heidary, AU - Schnitzler,P, Y1 - 2014/06/17/ PY - 2014/05/06/received PY - 2014/06/06/revised PY - 2014/06/09/accepted PY - 2014/7/6/entrez PY - 2014/7/6/pubmed PY - 2015/3/31/medline KW - Acute hepatitis KW - Autochthonous hepatitis E KW - Hepatitis E virus KW - Pregnancy SP - 170 EP - 2 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 61 IS - 1 N2 - Hepatitis E is usually a self-limiting disease and an important cause of acute hepatitis in endemic countries in Asia and Africa. However, the mortality rate for pregnant women infected with hepatitis E virus (HEV) in this area is about 25%. In Germany, sporadic cases of acute hepatitis E infections have been described and the number of autochthonous infections is increasing. Here we report an autochthonous HEV subgenotype 3c infection in a 27-year old pregnant woman. This is the first documented case of a hepatitis E infection during pregnancy in Germany. The patient presented in week 26 of gestation with acute hepatitis and elevated transaminases. During follow-up, she tested positive for anti-HEV antibodies. HEV viral load during the acute hepatitis was 2.3×10(6) copies/ml serum, however viremia declined and cleared rapidly. Sequence analysis revealed a HEV subgenotype 3c closely related to European isolates. The patient had not travelled outside Germany, had regular contact to animals, but the source of infection remains unclear. The newborn was delivered in week 40 of gestation in good health, HEV was not transmitted and liver enzymes were normal. In conclusion, hepatitis E should be considered in differential diagnosis in patients with acute hepatitis especially during pregnancy, even without travel history to countries with high endemicity. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/24996764/First_case_report_of_an_acute_hepatitis_E_subgenotype_3c_infection_during_pregnancy_in_Germany_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(14)00224-8 DB - PRIME DP - Unbound Medicine ER -