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Etiology and prognosis of non-convulsive status epilepticus.
J Clin Neurosci. 2014 Nov; 21(11):1915-9.JC

Abstract

Although non-convulsive status epilepticus (NCSE) is an important type of epilepsy, it is not often recognized. In order to analyze the clinical characteristics and outcome in patients with NCSE, we examined the medical records of patients with NCSE admitted to the Seoul National University Hospital between June 2005 and October 2008. The clinical details and electroencephalography records of 34 adult NCSE patients (aged over 16 years) were collected. Their mean age was 47 years (standard deviation 20 years, range, 16-87 years), and 20 were female. Twenty-seven patients (79.4%) showed decreased awareness with acute onset, and seven (20.6%) were obtunded or comatose. Ten patients (29.4%) had a history of epilepsy, and four (11.8%) had a history of stroke. NCSE was etiologically attributed to acute medical or neurological problems in 25 patients (73.5%), was cryptogenic in three (8.8%), and was secondary to underlying epilepsy in six (17.7%). Acute symptomatic etiology was associated with poor recovery (p=0.048), with all unresponsive patients in this acute symptomatic group. Eight (23.5%) of the 34 NCSE patients did not recover or died, whereas nine (26.5%) recovered. Our study shows that the presence of acute symptoms or central nervous system infection is associated with poor outcome, suggesting that a high level of vigilance is required to identify and prevent complications.

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Authors+Show Affiliations

Kang BS
Department of Neurology, Korea University Anam Hospital, Seoul, South Korea.
Jhang Y
Department of Neurology, Myongji Hospital, Goyang, South Korea.
Kim YS
Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.
Moon J
Department of Neurology, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Daehangno 101, Chongro-Gu, Seoul 110-744, South Korea.
Shin JW
Department of Neurology, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Daehangno 101, Chongro-Gu, Seoul 110-744, South Korea.
Moon HJ
Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, South Korea.
Lee ST
Department of Neurology, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Daehangno 101, Chongro-Gu, Seoul 110-744, South Korea.
Jung KH
Department of Neurology, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Daehangno 101, Chongro-Gu, Seoul 110-744, South Korea.
Chu K
Department of Neurology, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Daehangno 101, Chongro-Gu, Seoul 110-744, South Korea.
Park KI
Department of Neurology, Inje University, Seoul Paik Hospital, Seoul, South Korea.
Lee SK
Department of Neurology, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, College of Medicine, Seoul National University, Daehangno 101, Chongro-Gu, Seoul 110-744, South Korea. Electronic address: sangun2923@gmail.com.

MeSH

AdolescentAdultAgedAged, 80 and overAnticonvulsantsBrainBrain Diseases, MetabolicComaConsciousness DisordersElectroencephalographyEpilepsyFemaleHumansInfectionsMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingPersistent Vegetative StatePrognosisRepublic of KoreaRetrospective StudiesStatus EpilepticusStrokeYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24998856

Citation

Kang, Bong Su, et al. "Etiology and Prognosis of Non-convulsive Status Epilepticus." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 21, no. 11, 2014, pp. 1915-9.
Kang BS, Jhang Y, Kim YS, et al. Etiology and prognosis of non-convulsive status epilepticus. J Clin Neurosci. 2014;21(11):1915-9.
Kang, B. S., Jhang, Y., Kim, Y. S., Moon, J., Shin, J. W., Moon, H. J., Lee, S. T., Jung, K. H., Chu, K., Park, K. I., & Lee, S. K. (2014). Etiology and prognosis of non-convulsive status epilepticus. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 21(11), 1915-9. https://doi.org/10.1016/j.jocn.2014.03.018
Kang BS, et al. Etiology and Prognosis of Non-convulsive Status Epilepticus. J Clin Neurosci. 2014;21(11):1915-9. PubMed PMID: 24998856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology and prognosis of non-convulsive status epilepticus. AU - Kang,Bong Su, AU - Jhang,Yunsook, AU - Kim,Young-Soo, AU - Moon,Jangsup, AU - Shin,Jung-Won, AU - Moon,Hye Jin, AU - Lee,Soon-Tae, AU - Jung,Keun-Hwa, AU - Chu,Kon, AU - Park,Kyung-Il, AU - Lee,Sang Kun, Y1 - 2014/07/03/ PY - 2013/11/14/received PY - 2014/03/03/revised PY - 2014/03/08/accepted PY - 2014/7/8/entrez PY - 2014/7/8/pubmed PY - 2015/7/29/medline KW - Etiology KW - Non-convulsive status epilepticus KW - Prognosis SP - 1915 EP - 9 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 21 IS - 11 N2 - Although non-convulsive status epilepticus (NCSE) is an important type of epilepsy, it is not often recognized. In order to analyze the clinical characteristics and outcome in patients with NCSE, we examined the medical records of patients with NCSE admitted to the Seoul National University Hospital between June 2005 and October 2008. The clinical details and electroencephalography records of 34 adult NCSE patients (aged over 16 years) were collected. Their mean age was 47 years (standard deviation 20 years, range, 16-87 years), and 20 were female. Twenty-seven patients (79.4%) showed decreased awareness with acute onset, and seven (20.6%) were obtunded or comatose. Ten patients (29.4%) had a history of epilepsy, and four (11.8%) had a history of stroke. NCSE was etiologically attributed to acute medical or neurological problems in 25 patients (73.5%), was cryptogenic in three (8.8%), and was secondary to underlying epilepsy in six (17.7%). Acute symptomatic etiology was associated with poor recovery (p=0.048), with all unresponsive patients in this acute symptomatic group. Eight (23.5%) of the 34 NCSE patients did not recover or died, whereas nine (26.5%) recovered. Our study shows that the presence of acute symptoms or central nervous system infection is associated with poor outcome, suggesting that a high level of vigilance is required to identify and prevent complications. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/24998856/Etiology_and_prognosis_of_non_convulsive_status_epilepticus_ DB - PRIME DP - Unbound Medicine ER -