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Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway.
Anticancer Drugs. 2014 Oct; 25(9):1035-43.AD

Abstract

Matrine has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effect and molecular mechanism(s) of matrine on osteosarcoma are still unclear. Therefore, the aim of this study was to assess the effects of matrine and related mechanism(s) on osteosarcoma cells. In the study, we found that matrine inhibited the proliferation of osteosarcoma cells in vivo and in vitro and inhibited tumor cell metastasis in vitro at cytotoxic doses. Matrine also decreased the expression of the matrix metalloproteinases-2 and 9, decreased p50 and p65 nuclear translocation, and decreased the phosphorylated level of I-κ-B (IκB)-β. In addition, matrine reduced the phosphorylated levels of extracellular signal-regulated kinase 1/2 proteins, which regulate the invasion of poorly differentiated cancer cells. Finally, when U2OS cells were grown as xenografts in nude mice, intragastric administration of matrine induced a significant dose-dependent decrease in tumor growth. These results show the anticancer properties of matrine, which include the inhibition of invasion and proliferation of human osteosarcoma cells.

Authors+Show Affiliations

aHospital Department of Foot and Ankle Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine bAnesthesia Department, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24999836

Citation

Li, Yi, et al. "Matrine Inhibits the Invasive Properties of Human Osteosarcoma Cells By Downregulating the ERK-NF-κB Pathway." Anti-cancer Drugs, vol. 25, no. 9, 2014, pp. 1035-43.
Li Y, Zhang ZN, Zhao HM, et al. Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway. Anticancer Drugs. 2014;25(9):1035-43.
Li, Y., Zhang, Z. N., Zhao, H. M., Tong, Z. C., Yang, J., Wang, H., & Liang, X. J. (2014). Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway. Anti-cancer Drugs, 25(9), 1035-43. https://doi.org/10.1097/CAD.0000000000000136
Li Y, et al. Matrine Inhibits the Invasive Properties of Human Osteosarcoma Cells By Downregulating the ERK-NF-κB Pathway. Anticancer Drugs. 2014;25(9):1035-43. PubMed PMID: 24999836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway. AU - Li,Yi, AU - Zhang,Zhen-Ni, AU - Zhao,Hong-Mou, AU - Tong,Zhi-Chao, AU - Yang,Jie, AU - Wang,Hu, AU - Liang,Xiao-Jun, PY - 2014/7/8/entrez PY - 2014/7/8/pubmed PY - 2015/4/8/medline SP - 1035 EP - 43 JF - Anti-cancer drugs JO - Anticancer Drugs VL - 25 IS - 9 N2 - Matrine has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effect and molecular mechanism(s) of matrine on osteosarcoma are still unclear. Therefore, the aim of this study was to assess the effects of matrine and related mechanism(s) on osteosarcoma cells. In the study, we found that matrine inhibited the proliferation of osteosarcoma cells in vivo and in vitro and inhibited tumor cell metastasis in vitro at cytotoxic doses. Matrine also decreased the expression of the matrix metalloproteinases-2 and 9, decreased p50 and p65 nuclear translocation, and decreased the phosphorylated level of I-κ-B (IκB)-β. In addition, matrine reduced the phosphorylated levels of extracellular signal-regulated kinase 1/2 proteins, which regulate the invasion of poorly differentiated cancer cells. Finally, when U2OS cells were grown as xenografts in nude mice, intragastric administration of matrine induced a significant dose-dependent decrease in tumor growth. These results show the anticancer properties of matrine, which include the inhibition of invasion and proliferation of human osteosarcoma cells. SN - 1473-5741 UR - https://www.unboundmedicine.com/medline/citation/24999836/Matrine_inhibits_the_invasive_properties_of_human_osteosarcoma_cells_by_downregulating_the_ERK_NF_κB_pathway_ L2 - https://doi.org/10.1097/CAD.0000000000000136 DB - PRIME DP - Unbound Medicine ER -