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Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling.
Am J Chin Med. 2014; 42(4):1021-34.AJ

Abstract

Hair loss is accompanied by keratinocyte apoptosis-regression during catagen and prolonged telogen. Angelica sinensis was reported to promote hair growth in vitro. Based on previous studies, we explored the hair growth effect and the mechanism of A. sinensis related to keratinocyte apoptosis-regression during catagen in mice. The 70% Ethanol extract of A. sinensis was applied topically at doses of 1 and 100 mg/mL to the dorsa of C57BL/6 mice for 2 weeks. The A. sinensis-treated group showed noticeable hair regrowth. Treatment with A. sinensis restored the lengths of hair shafts and size of hair follicles. In addition, mice treated with A. sinensis showed notably decreased apoptotic cells, along with a significant change in the expression of cleaved caspase-3 and the ratio of a pair of apoptosis-associated proteins: Bcl-2 and Bax. Also, A. sinensis inhibited the nuclear translocation of NF-κB, the phosphorylation of IκB-α, the phosphorylation of three mitogen-activated protein MAP kinases, and the activation of c-Jun with decreased TNF-α. These findings reveal a role of A. sinensis as an alternative treatment for hair loss that acts through hair cycle pathways associated with apoptosis regression during catagen.

Authors+Show Affiliations

College of Korean Medicine and Institute of Korean Medicine, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25004889

Citation

Kim, Mi Hye, et al. "Angelica Sinensis Induces Hair Regrowth Via the Inhibition of Apoptosis Signaling." The American Journal of Chinese Medicine, vol. 42, no. 4, 2014, pp. 1021-34.
Kim MH, Choi YY, Cho IH, et al. Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling. Am J Chin Med. 2014;42(4):1021-34.
Kim, M. H., Choi, Y. Y., Cho, I. H., Hong, J., Kim, S. H., & Yang, W. M. (2014). Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling. The American Journal of Chinese Medicine, 42(4), 1021-34. https://doi.org/10.1142/S0192415X14500645
Kim MH, et al. Angelica Sinensis Induces Hair Regrowth Via the Inhibition of Apoptosis Signaling. Am J Chin Med. 2014;42(4):1021-34. PubMed PMID: 25004889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling. AU - Kim,Mi Hye, AU - Choi,You Yeon, AU - Cho,Ik-Hyun, AU - Hong,Jongki, AU - Kim,Sung-Hoon, AU - Yang,Woong Mo, PY - 2014/7/10/entrez PY - 2014/7/10/pubmed PY - 2015/1/21/medline KW - Angelica sinensis (Oliv.) Diels KW - Apoptosis KW - Hair Follicle KW - Hair Loss SP - 1021 EP - 34 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 42 IS - 4 N2 - Hair loss is accompanied by keratinocyte apoptosis-regression during catagen and prolonged telogen. Angelica sinensis was reported to promote hair growth in vitro. Based on previous studies, we explored the hair growth effect and the mechanism of A. sinensis related to keratinocyte apoptosis-regression during catagen in mice. The 70% Ethanol extract of A. sinensis was applied topically at doses of 1 and 100 mg/mL to the dorsa of C57BL/6 mice for 2 weeks. The A. sinensis-treated group showed noticeable hair regrowth. Treatment with A. sinensis restored the lengths of hair shafts and size of hair follicles. In addition, mice treated with A. sinensis showed notably decreased apoptotic cells, along with a significant change in the expression of cleaved caspase-3 and the ratio of a pair of apoptosis-associated proteins: Bcl-2 and Bax. Also, A. sinensis inhibited the nuclear translocation of NF-κB, the phosphorylation of IκB-α, the phosphorylation of three mitogen-activated protein MAP kinases, and the activation of c-Jun with decreased TNF-α. These findings reveal a role of A. sinensis as an alternative treatment for hair loss that acts through hair cycle pathways associated with apoptosis regression during catagen. SN - 1793-6853 UR - https://www.unboundmedicine.com/medline/citation/25004889/Angelica_sinensis_induces_hair_regrowth_via_the_inhibition_of_apoptosis_signaling_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X14500645?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -