Tags

Type your tag names separated by a space and hit enter

Synthesis and surface immobilization of antibacterial hybrid silver-poly(l-lactide) nanoparticles.
Nanotechnology. 2014 Aug 01; 25(30):305102.N

Abstract

Infections associated with medical devices are a substantial healthcare problem. Consequently, there has been increasing research and technological efforts directed toward the development of coatings that are capable of preventing bacterial colonization of the device surface. Herein, we report on novel hybrid silver loaded poly(L-lactic acid) nanoparticles (PLLA-AgNPs) with narrowly distributed sizes (17 ± 3 nm) prepared using a combination of solvent evaporation and mini-emulsion technology. These particles were then immobilized onto solid surfaces premodified with a thin layer of allylamine plasma polymer (AApp). The antibacterial efficacy of the PLLA-AgNPs nanoparticles was studied in vitro against both gram-positive (Staphylococcus epidermidis) and gram-negative (Escherichia coli) bacteria. The minimal inhibitory concentration values against Staphylococcus epidermidis and Escherichia coli were 0.610 and 1.156 μg · mL(-1), respectively. The capacity of the prepared coatings to prevent bacterial surface colonization was assessed in the presence of Staphylococcus epidermidis, which is a strong biofilm former that causes substantial problems with medical device associated infections. The level of inhibition of bacterial growth was 98%. The substrate independent nature and the high antibacterial efficacy of coatings presented in this study may offer new alternatives for antibacterial coatings for medical devices.

Authors+Show Affiliations

School of Engineering, University of South Australia, Mawson Lakes, SA 5095 Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25007946

Citation

Taheri, Shima, et al. "Synthesis and Surface Immobilization of Antibacterial Hybrid Silver-poly(l-lactide) Nanoparticles." Nanotechnology, vol. 25, no. 30, 2014, p. 305102.
Taheri S, Baier G, Majewski P, et al. Synthesis and surface immobilization of antibacterial hybrid silver-poly(l-lactide) nanoparticles. Nanotechnology. 2014;25(30):305102.
Taheri, S., Baier, G., Majewski, P., Barton, M., Förch, R., Landfester, K., & Vasilev, K. (2014). Synthesis and surface immobilization of antibacterial hybrid silver-poly(l-lactide) nanoparticles. Nanotechnology, 25(30), 305102. https://doi.org/10.1088/0957-4484/25/30/305102
Taheri S, et al. Synthesis and Surface Immobilization of Antibacterial Hybrid Silver-poly(l-lactide) Nanoparticles. Nanotechnology. 2014 Aug 1;25(30):305102. PubMed PMID: 25007946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and surface immobilization of antibacterial hybrid silver-poly(l-lactide) nanoparticles. AU - Taheri,Shima, AU - Baier,Grit, AU - Majewski,Peter, AU - Barton,Mary, AU - Förch,Renate, AU - Landfester,Katharina, AU - Vasilev,Krasimir, Y1 - 2014/07/10/ PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2015/10/3/medline SP - 305102 EP - 305102 JF - Nanotechnology JO - Nanotechnology VL - 25 IS - 30 N2 - Infections associated with medical devices are a substantial healthcare problem. Consequently, there has been increasing research and technological efforts directed toward the development of coatings that are capable of preventing bacterial colonization of the device surface. Herein, we report on novel hybrid silver loaded poly(L-lactic acid) nanoparticles (PLLA-AgNPs) with narrowly distributed sizes (17 ± 3 nm) prepared using a combination of solvent evaporation and mini-emulsion technology. These particles were then immobilized onto solid surfaces premodified with a thin layer of allylamine plasma polymer (AApp). The antibacterial efficacy of the PLLA-AgNPs nanoparticles was studied in vitro against both gram-positive (Staphylococcus epidermidis) and gram-negative (Escherichia coli) bacteria. The minimal inhibitory concentration values against Staphylococcus epidermidis and Escherichia coli were 0.610 and 1.156 μg · mL(-1), respectively. The capacity of the prepared coatings to prevent bacterial surface colonization was assessed in the presence of Staphylococcus epidermidis, which is a strong biofilm former that causes substantial problems with medical device associated infections. The level of inhibition of bacterial growth was 98%. The substrate independent nature and the high antibacterial efficacy of coatings presented in this study may offer new alternatives for antibacterial coatings for medical devices. SN - 1361-6528 UR - https://www.unboundmedicine.com/medline/citation/25007946/Synthesis_and_surface_immobilization_of_antibacterial_hybrid_silver_poly_l_lactide__nanoparticles_ L2 - https://doi.org/10.1088/0957-4484/25/30/305102 DB - PRIME DP - Unbound Medicine ER -