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Prototyped grafting plate for reconstruction of mandibular defects.
J Craniomaxillofac Surg. 2014 Dec; 42(8):1723-9.JC

Abstract

To esthetically and functionally restore a 40-mm canine mandibular discontinuity defect using a custom-made titanium bone-grafting plate in combination with autologous iliac bone grafts. Individualized titanium bone-grafting plates were manufactured using a series of techniques, including reverse engineering, computer aided design, rapid prototyping and titanium casting. A 40-mm discontinuous defect in the right mandibular body was created in 9 hybrid dogs. The defect was restored immediately using the customized plate in combination with autologous cancellous iliac blocks. Sequential radionuclide bone imaging was performed to evaluate the bone metabolism and reconstitution of the grafts. The specimens were evaluated by biomechanical testing, 3-dimensional microcomputed tomographic scanning, and histological examination. The results revealed that the symmetry of the mandibles was reconstructed using the customized grafting plate, and the bony continuity of the mandibles was restored. By 12 weeks after the operation, the cancellous iliac grafts became a hard bone block, which was of comparable strength to native mandibles. A fibrous tissue intermediate was found between the remodelled bone graft and the titanium plate. The results indicate that the prototyped grafting plate can be used to restore mandibular discontinuous defects, and satisfactory aesthetical and functional reconstruction can be achieved.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China.

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China.

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China.

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China.

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China.

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China.

Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, 145 Western Changle Road, Xi'an 710032, Shaanxi, PR China.

Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, 145 Western Changle Road, Xi'an 710032, Shaanxi, PR China. Electronic address: liuyanpu@fmmu.edu.cn.

Department of Otolaryngology Head and Neck Surgery, The 306th Hospital of PLA, 9 Anxiangbeili Street, Chaoyang District, Beijing 100101, PR China. Electronic address: ent306ww@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25008032

Citation

Zhou, Libin, et al. "Prototyped Grafting Plate for Reconstruction of Mandibular Defects." Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery, vol. 42, no. 8, 2014, pp. 1723-9.

Zhou L, Wang P, Han H, et al. Prototyped grafting plate for reconstruction of mandibular defects. J Craniomaxillofac Surg. 2014;42(8):1723-9.

Zhou, L., Wang, P., Han, H., Li, B., Wang, H., Wang, G., Zhao, J., Liu, Y., & Wu, W. (2014). Prototyped grafting plate for reconstruction of mandibular defects. Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery, 42(8), 1723-9. https://doi.org/10.1016/j.jcms.2014.06.006

Zhou L, et al. Prototyped Grafting Plate for Reconstruction of Mandibular Defects. J Craniomaxillofac Surg. 2014;42(8):1723-9. PubMed PMID: 25008032.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Prototyped grafting plate for reconstruction of mandibular defects. AU - Zhou,Libin, AU - Wang,Peilin, AU - Han,Haolun, AU - Li,Baowei, AU - Wang,Hongnan, AU - Wang,Gang, AU - Zhao,Jinlong, AU - Liu,Yanpu, AU - Wu,Wei, Y1 - 2014/06/13/ PY - 2013/11/14/received PY - 2014/04/02/revised PY - 2014/06/04/accepted PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2016/3/10/medline KW - Autologous bone grafting KW - Computer aided design KW - Mandible reconstruction KW - Rapid prototyping SP - 1723 EP - 9 JF - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JO - J Craniomaxillofac Surg VL - 42 IS - 8 N2 - To esthetically and functionally restore a 40-mm canine mandibular discontinuity defect using a custom-made titanium bone-grafting plate in combination with autologous iliac bone grafts. Individualized titanium bone-grafting plates were manufactured using a series of techniques, including reverse engineering, computer aided design, rapid prototyping and titanium casting. A 40-mm discontinuous defect in the right mandibular body was created in 9 hybrid dogs. The defect was restored immediately using the customized plate in combination with autologous cancellous iliac blocks. Sequential radionuclide bone imaging was performed to evaluate the bone metabolism and reconstitution of the grafts. The specimens were evaluated by biomechanical testing, 3-dimensional microcomputed tomographic scanning, and histological examination. The results revealed that the symmetry of the mandibles was reconstructed using the customized grafting plate, and the bony continuity of the mandibles was restored. By 12 weeks after the operation, the cancellous iliac grafts became a hard bone block, which was of comparable strength to native mandibles. A fibrous tissue intermediate was found between the remodelled bone graft and the titanium plate. The results indicate that the prototyped grafting plate can be used to restore mandibular discontinuous defects, and satisfactory aesthetical and functional reconstruction can be achieved. SN - 1878-4119 UR - https://www.unboundmedicine.com/medline/citation/25008032/Prototyped_grafting_plate_for_reconstruction_of_mandibular_defects_ DB - PRIME DP - Unbound Medicine ER -