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Renoprotective effect of atorvastatin on STZ-diabetic rats through attenuating kidney-associated dysmetabolism.
Eur J Pharmacol. 2014 Oct 05; 740:9-14.EJ

Abstract

Atorvastatin (AT) has been alternatively used for managing diabetic complications in clinic. However, AT-related therapeutic potentiality remains relatively unexplored, especially in diabetic nephropathy. This study aimed to investigate the underlying potentiality that AT exerted on anti-diabetic nephropathy role against streptozotocin (STZ)-induced kidney injury in rats. STZ-diabetic rats were intragastrically administered with AT (10, 20 mg/kg/d) for consecutive 8 weeks. The effects of AT on body weight, levels of blood glucose, lipometabolism, redox state, cellular metabolism, regulator factor and kidney morphological changes were monitored by routine measurement, biochemistry assay, PT-PCR analysis, ultrastructural and pathological observations, respectively. Compared with the diabetic nephropathy rats, AT elevated the body weight of diabetic nephropathy rats (P<0.01), effectively reduced the blood glucose level (P<0.01), increased the levels of insulin and high-density lipoprotein cholesterol (HDL-C) in plasma (P<0.01), and decreased the 24 h urine protein content and serum concentrations of low-density lipoprotein cholesterol (LDL-C) (P<0.01). Meanwhile, increase in kidney tissue, the intrarenal activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were enhanced, while the malonaldehyde (MDA) content was reduced (P<0.01). In addition, the expression of transforming growth factor beta 1 (TGF-β1) mRNA in kidney tissue was notably down-regulated (P<0.01). Furthermore, AT contributed to alleviating STZ-induced nephritic damages in rats. These results demonstrate that atorvastatin exerts the effective protective role against kidney injuries of STZ-induced diabetic nephropathy rat, which the underlying mechanisms are associated with ameliorating glyco, lipometabolism, enhancing antioxidant ability, and mitigating renal damage.

Authors+Show Affiliations

Department of Endocrinology, Affiliated Hospital of Guilin Medical University, Guilin 541001, China.Department of Endocrinology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China.Department of Endocrinology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China.Department of Endocrinology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China.Department of Endocrinology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China.Department of Neurology, Affiliated Hospital of Guilin Medical University, Guilin 541001, China. Electronic address: lihao_hospital@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25008071

Citation

Zhou, Suxian, et al. "Renoprotective Effect of Atorvastatin On STZ-diabetic Rats Through Attenuating Kidney-associated Dysmetabolism." European Journal of Pharmacology, vol. 740, 2014, pp. 9-14.
Zhou S, Zhao P, Li Y, et al. Renoprotective effect of atorvastatin on STZ-diabetic rats through attenuating kidney-associated dysmetabolism. Eur J Pharmacol. 2014;740:9-14.
Zhou, S., Zhao, P., Li, Y., Deng, T., Tian, L., & Li, H. (2014). Renoprotective effect of atorvastatin on STZ-diabetic rats through attenuating kidney-associated dysmetabolism. European Journal of Pharmacology, 740, 9-14. https://doi.org/10.1016/j.ejphar.2014.06.055
Zhou S, et al. Renoprotective Effect of Atorvastatin On STZ-diabetic Rats Through Attenuating Kidney-associated Dysmetabolism. Eur J Pharmacol. 2014 Oct 5;740:9-14. PubMed PMID: 25008071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renoprotective effect of atorvastatin on STZ-diabetic rats through attenuating kidney-associated dysmetabolism. AU - Zhou,Suxian, AU - Zhao,Ping, AU - Li,Yingfang, AU - Deng,Tingting, AU - Tian,Lihua, AU - Li,Hao, Y1 - 2014/07/05/ PY - 2014/01/04/received PY - 2014/06/21/revised PY - 2014/06/23/accepted PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2015/10/28/medline KW - Atorvastatin KW - Diabetic nephropathy KW - Metabolism KW - Renoprotection SP - 9 EP - 14 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 740 N2 - Atorvastatin (AT) has been alternatively used for managing diabetic complications in clinic. However, AT-related therapeutic potentiality remains relatively unexplored, especially in diabetic nephropathy. This study aimed to investigate the underlying potentiality that AT exerted on anti-diabetic nephropathy role against streptozotocin (STZ)-induced kidney injury in rats. STZ-diabetic rats were intragastrically administered with AT (10, 20 mg/kg/d) for consecutive 8 weeks. The effects of AT on body weight, levels of blood glucose, lipometabolism, redox state, cellular metabolism, regulator factor and kidney morphological changes were monitored by routine measurement, biochemistry assay, PT-PCR analysis, ultrastructural and pathological observations, respectively. Compared with the diabetic nephropathy rats, AT elevated the body weight of diabetic nephropathy rats (P<0.01), effectively reduced the blood glucose level (P<0.01), increased the levels of insulin and high-density lipoprotein cholesterol (HDL-C) in plasma (P<0.01), and decreased the 24 h urine protein content and serum concentrations of low-density lipoprotein cholesterol (LDL-C) (P<0.01). Meanwhile, increase in kidney tissue, the intrarenal activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were enhanced, while the malonaldehyde (MDA) content was reduced (P<0.01). In addition, the expression of transforming growth factor beta 1 (TGF-β1) mRNA in kidney tissue was notably down-regulated (P<0.01). Furthermore, AT contributed to alleviating STZ-induced nephritic damages in rats. These results demonstrate that atorvastatin exerts the effective protective role against kidney injuries of STZ-induced diabetic nephropathy rat, which the underlying mechanisms are associated with ameliorating glyco, lipometabolism, enhancing antioxidant ability, and mitigating renal damage. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/25008071/Renoprotective_effect_of_atorvastatin_on_STZ_diabetic_rats_through_attenuating_kidney_associated_dysmetabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(14)00506-8 DB - PRIME DP - Unbound Medicine ER -