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Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis.
Clin Nutr 2015; 34(4):620-6CN

Abstract

BACKGROUND & AIMS

The association between dietary vitamin A, retinol intake and blood retinol level and gastric cancer risk has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue.

METHODS

PUBMED and EMBASE were searched, supplemented with manual-screening for relevant publications. Meta-analyses were performed to evaluate the association between vitamin A, retinol dietary intake or blood retinol level and gastric cancer risk.

RESULTS

Thirty-one studies were included in this meta-analysis. Comparing the highest with the lowest categories, vitamin A intake significantly reduced gastric cancer risk (pooled RR = 0.66, 95% CI: 0.52-0.84), whereas a marginally inverse association was found between retinol intake (pooled RR = 0.94, 95% CI: 0.87-1.03) or blood retinol level (pooled RR = 0.87, 95% CI: 0.73-1.05) and gastric cancer risk. Interestingly, the results of subgroup analysis indicated that high vitamin A intake and blood retinol level were associated with reduced gastric cancer risk in Western countries, while a marginally inverse association was found between retinol and gastric cancer risk in Western countries.

CONCLUSIONS

Vitamin A intake was inversely associated with gastric cancer risk, while no significant association was found with retinol intake or blood retinol level.

Authors+Show Affiliations

Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China.Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China.Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China.Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China.Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: xep@zju.edu.cn.Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China; Department of Medicine, Hangzhou Normal University, 16, Xuelin Str., Xiasha High Education Zone, Hangzhou, Zhejiang 310036, China. Electronic address: gastate@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25008141

Citation

Wu, Yihua, et al. "Association Between Vitamin A, Retinol Intake and Blood Retinol Level and Gastric Cancer Risk: a Meta-analysis." Clinical Nutrition (Edinburgh, Scotland), vol. 34, no. 4, 2015, pp. 620-6.
Wu Y, Ye Y, Shi Y, et al. Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. Clin Nutr. 2015;34(4):620-6.
Wu, Y., Ye, Y., Shi, Y., Li, P., Xu, J., Chen, K., ... Yang, J. (2015). Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. Clinical Nutrition (Edinburgh, Scotland), 34(4), pp. 620-6. doi:10.1016/j.clnu.2014.06.007.
Wu Y, et al. Association Between Vitamin A, Retinol Intake and Blood Retinol Level and Gastric Cancer Risk: a Meta-analysis. Clin Nutr. 2015;34(4):620-6. PubMed PMID: 25008141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. AU - Wu,Yihua, AU - Ye,Yao, AU - Shi,Yu, AU - Li,Peiwei, AU - Xu,Jinming, AU - Chen,Kun, AU - Xu,Enping, AU - Yang,Jun, Y1 - 2014/06/23/ PY - 2013/11/21/received PY - 2014/05/15/revised PY - 2014/06/17/accepted PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2016/3/26/medline KW - Gastric cancer KW - Incidence KW - Meta-analysis KW - Retinol KW - Vitamin A SP - 620 EP - 6 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 34 IS - 4 N2 - BACKGROUND & AIMS: The association between dietary vitamin A, retinol intake and blood retinol level and gastric cancer risk has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue. METHODS: PUBMED and EMBASE were searched, supplemented with manual-screening for relevant publications. Meta-analyses were performed to evaluate the association between vitamin A, retinol dietary intake or blood retinol level and gastric cancer risk. RESULTS: Thirty-one studies were included in this meta-analysis. Comparing the highest with the lowest categories, vitamin A intake significantly reduced gastric cancer risk (pooled RR = 0.66, 95% CI: 0.52-0.84), whereas a marginally inverse association was found between retinol intake (pooled RR = 0.94, 95% CI: 0.87-1.03) or blood retinol level (pooled RR = 0.87, 95% CI: 0.73-1.05) and gastric cancer risk. Interestingly, the results of subgroup analysis indicated that high vitamin A intake and blood retinol level were associated with reduced gastric cancer risk in Western countries, while a marginally inverse association was found between retinol and gastric cancer risk in Western countries. CONCLUSIONS: Vitamin A intake was inversely associated with gastric cancer risk, while no significant association was found with retinol intake or blood retinol level. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/25008141/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(14)00171-X DB - PRIME DP - Unbound Medicine ER -