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Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.
J Nutr. 2014 Sep; 144(9):1356-63.JN

Abstract

The unclear link between intake of polyunsaturated fatty acids (PUFAs) and risk of cardiovascular disease (CVD) could depend on genetic differences between individuals. Minor alleles of single-nucleotide polymorphisms (SNPs) in the ∆5 fatty acid desaturase (FADS) 1 gene were associated with lower blood concentrations of long-chain ω-3 (n-3) and ω-6 (n-6) PUFAs, indicating an associated loss of function effect. We examined whether the SNP rs174546 in FADS1 modifies the association between PUFA intakes and CVD risk. We included 24,032 participants (62% women, aged 44-74 y) from the Malmö Diet and Cancer cohort without prevalent CVD and diabetes. During a mean follow-up of 14 y, 2648 CVD cases were identified. Diet was assessed by a modified diet history method. A borderline interaction was observed between the α-linolenic acid (ALA) (18:3n-3)-to-linoleic acid (LA) (18:2n-6) intake ratio and FADS1 genotype on CVD incidence (P = 0.06). The ALA-to-LA intake ratio was inversely associated with CVD risk only among participants homozygous for the minor T-allele (HR for quintile 5 vs. quintile 1 = 0.72; 95% CI: 0.50, 1.04; P-trend = 0.049). When excluding participants reporting unstable food habits in the past (35%), the interaction between the ALA-to-LA intake ratio and FADS1 genotype on CVD incidence was strengthened and statistically significant (P = 0.04). Additionally, we observed a significant interaction between ALA and FADS1 genotype on ischemic stroke incidence (P = 0.03). ALA was inversely associated with ischemic stroke only among TT genotype carriers (HR for quintile 5 vs. quintile 1 = 0.50; 95% CI: 0.27, 0.94; P-trend = 0.02). In this large cohort, we found some weak, but not convincing, evidence of effect modification by genetic variation in FADS1 on the associations between PUFA intakes and CVD risk. For the 11% of the population homozygous for the minor T-allele of rs174546 that associates with lower ∆5 FADS activity, high ALA intake and ALA-to-LA intake ratio may be preferable in the prevention of CVD and ischemic stroke.

Authors+Show Affiliations

Diabetes and Cardiovascular Disease-Genetic Epidemiology sophie.hellstrand@med.lu.se.Diabetes and Cardiovascular Disease-Genetic Epidemiology.Nutrition Epidemiology, and.Cardiovascular Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.Diabetes and Cardiovascular Disease-Genetic Epidemiology.Diabetes and Cardiovascular Disease-Genetic Epidemiology.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25008580

Citation

Hellstrand, Sophie, et al. "Genetic Variation in FADS1 Has Little Effect On the Association Between Dietary PUFA Intake and Cardiovascular Disease." The Journal of Nutrition, vol. 144, no. 9, 2014, pp. 1356-63.
Hellstrand S, Ericson U, Gullberg B, et al. Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. J Nutr. 2014;144(9):1356-63.
Hellstrand, S., Ericson, U., Gullberg, B., Hedblad, B., Orho-Melander, M., & Sonestedt, E. (2014). Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. The Journal of Nutrition, 144(9), 1356-63. https://doi.org/10.3945/jn.114.192708
Hellstrand S, et al. Genetic Variation in FADS1 Has Little Effect On the Association Between Dietary PUFA Intake and Cardiovascular Disease. J Nutr. 2014;144(9):1356-63. PubMed PMID: 25008580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. AU - Hellstrand,Sophie, AU - Ericson,Ulrika, AU - Gullberg,Bo, AU - Hedblad,Bo, AU - Orho-Melander,Marju, AU - Sonestedt,Emily, Y1 - 2014/07/09/ PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2014/12/17/medline SP - 1356 EP - 63 JF - The Journal of nutrition JO - J. Nutr. VL - 144 IS - 9 N2 - The unclear link between intake of polyunsaturated fatty acids (PUFAs) and risk of cardiovascular disease (CVD) could depend on genetic differences between individuals. Minor alleles of single-nucleotide polymorphisms (SNPs) in the ∆5 fatty acid desaturase (FADS) 1 gene were associated with lower blood concentrations of long-chain ω-3 (n-3) and ω-6 (n-6) PUFAs, indicating an associated loss of function effect. We examined whether the SNP rs174546 in FADS1 modifies the association between PUFA intakes and CVD risk. We included 24,032 participants (62% women, aged 44-74 y) from the Malmö Diet and Cancer cohort without prevalent CVD and diabetes. During a mean follow-up of 14 y, 2648 CVD cases were identified. Diet was assessed by a modified diet history method. A borderline interaction was observed between the α-linolenic acid (ALA) (18:3n-3)-to-linoleic acid (LA) (18:2n-6) intake ratio and FADS1 genotype on CVD incidence (P = 0.06). The ALA-to-LA intake ratio was inversely associated with CVD risk only among participants homozygous for the minor T-allele (HR for quintile 5 vs. quintile 1 = 0.72; 95% CI: 0.50, 1.04; P-trend = 0.049). When excluding participants reporting unstable food habits in the past (35%), the interaction between the ALA-to-LA intake ratio and FADS1 genotype on CVD incidence was strengthened and statistically significant (P = 0.04). Additionally, we observed a significant interaction between ALA and FADS1 genotype on ischemic stroke incidence (P = 0.03). ALA was inversely associated with ischemic stroke only among TT genotype carriers (HR for quintile 5 vs. quintile 1 = 0.50; 95% CI: 0.27, 0.94; P-trend = 0.02). In this large cohort, we found some weak, but not convincing, evidence of effect modification by genetic variation in FADS1 on the associations between PUFA intakes and CVD risk. For the 11% of the population homozygous for the minor T-allele of rs174546 that associates with lower ∆5 FADS activity, high ALA intake and ALA-to-LA intake ratio may be preferable in the prevention of CVD and ischemic stroke. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/25008580/Genetic_variation_in_FADS1_has_little_effect_on_the_association_between_dietary_PUFA_intake_and_cardiovascular_disease_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.114.192708 DB - PRIME DP - Unbound Medicine ER -