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Recent outbreak of scrub typhus in North Western part of India.
Indian J Med Microbiol 2014 Jul-Sep; 32(3):247-50IJ

Abstract

BACKGROUND

Scrub typhus usually affects previously healthy active persons and if undiagnosed or diagnosed late, may prove to be life-threatening. Diagnosis of scrub typhus should be largely based on a high index of suspicion and careful clinical, laboratory and epidemiological evaluation.

OBJECTIVE

To describe the diverse clinical and laboratory manifestations of scrub typhus diagnosed in Mahatma Gandhi Medical College and Hospital, Jaipur.

MATERIALS AND METHODS

All cases of febrile illness diagnosed as scrub typhus over a period of 3 months were analysed. Diagnosis was based on ELISA test for antibody detection against 56 kDa antigen.

RESULTS

Forty-two cases of scrub typhus were seen over a period of 3 months (October, 2012-December, 2012). Common symptoms were high grade fever of 4-30 days duration, cough, haemoptysis and breathlessness. Eschar was not seen even in a single patient. Liver enzymes were elevated in nearly all cases (95.9%). Multiple organ dysfunction syndrome (MODS) was present in 16.66% of our patients (7 out of 42). Hypotension (6 patients, 14.2%), renal impairment (9 out of 15 patients, 60%), acute respiratory distress syndrome (4 patients, 9.52%) and meningitis (4 patients, 9.52%) were some of the important complications. There was a dramatic response to doxycycline in nearly all the patients, but initially when the disease was not diagnosed, seven patients had died.

CONCLUSION

Scrub typhus has emerged as an important cause of febrile illness in Jaipur. Empirical treatment with doxycycline is justified in endemic areas.

Authors+Show Affiliations

No affiliation info availableDepartment of Microbiology, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25008815

Citation

Sinha, Parul, et al. "Recent Outbreak of Scrub Typhus in North Western Part of India." Indian Journal of Medical Microbiology, vol. 32, no. 3, 2014, pp. 247-50.
Sinha P, Gupta S, Dawra R, et al. Recent outbreak of scrub typhus in North Western part of India. Indian J Med Microbiol. 2014;32(3):247-50.
Sinha, P., Gupta, S., Dawra, R., & Rijhawan, P. (2014). Recent outbreak of scrub typhus in North Western part of India. Indian Journal of Medical Microbiology, 32(3), pp. 247-50. doi:10.4103/0255-0857.136552.
Sinha P, et al. Recent Outbreak of Scrub Typhus in North Western Part of India. Indian J Med Microbiol. 2014;32(3):247-50. PubMed PMID: 25008815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent outbreak of scrub typhus in North Western part of India. AU - Sinha,Parul, AU - Gupta,Sweta, AU - Dawra,Romika, AU - Rijhawan,Puneet, PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2015/3/3/medline SP - 247 EP - 50 JF - Indian journal of medical microbiology JO - Indian J Med Microbiol VL - 32 IS - 3 N2 - BACKGROUND: Scrub typhus usually affects previously healthy active persons and if undiagnosed or diagnosed late, may prove to be life-threatening. Diagnosis of scrub typhus should be largely based on a high index of suspicion and careful clinical, laboratory and epidemiological evaluation. OBJECTIVE: To describe the diverse clinical and laboratory manifestations of scrub typhus diagnosed in Mahatma Gandhi Medical College and Hospital, Jaipur. MATERIALS AND METHODS: All cases of febrile illness diagnosed as scrub typhus over a period of 3 months were analysed. Diagnosis was based on ELISA test for antibody detection against 56 kDa antigen. RESULTS: Forty-two cases of scrub typhus were seen over a period of 3 months (October, 2012-December, 2012). Common symptoms were high grade fever of 4-30 days duration, cough, haemoptysis and breathlessness. Eschar was not seen even in a single patient. Liver enzymes were elevated in nearly all cases (95.9%). Multiple organ dysfunction syndrome (MODS) was present in 16.66% of our patients (7 out of 42). Hypotension (6 patients, 14.2%), renal impairment (9 out of 15 patients, 60%), acute respiratory distress syndrome (4 patients, 9.52%) and meningitis (4 patients, 9.52%) were some of the important complications. There was a dramatic response to doxycycline in nearly all the patients, but initially when the disease was not diagnosed, seven patients had died. CONCLUSION: Scrub typhus has emerged as an important cause of febrile illness in Jaipur. Empirical treatment with doxycycline is justified in endemic areas. SN - 1998-3646 UR - https://www.unboundmedicine.com/medline/citation/25008815/Recent_outbreak_of_scrub_typhus_in_North_Western_part_of_India_ L2 - http://www.ijmm.org/article.asp?issn=0255-0857;year=2014;volume=32;issue=3;spage=247;epage=250;aulast=Sinha DB - PRIME DP - Unbound Medicine ER -