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Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy.
Clin Vaccine Immunol. 2014 Sep; 21(9):1364-8.CV

Abstract

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

Links

Publisher Full Text
ncbi.nlm.nih.gov
cvi.asm.org
PMC Free PDF

Authors+Show Affiliations

Caceres DH
Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia.
Scheel CM
Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, Georgia, USA.
Tobón AM
Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia Hospital La María, Medellín, Colombia.
Ahlquist Cleveland A
Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, Georgia, USA.
Restrepo A
Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia.
Brandt ME
Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, Georgia, USA.
Chiller T
Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, Georgia, USA.
Gómez BL
Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia Universidad del Rosario, School of Medicine and Health Sciences, BogotÁ, Colombia beatrizlgomez@hotmail.com.

MeSH

AIDS-Related Opportunistic InfectionsAntigens, FungalClinical Laboratory TechniquesCohort StudiesColombiaDrug MonitoringEnzyme-Linked Immunosorbent AssayHistoplasmaHistoplasmosisHumansProspective StudiesSensitivity and Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Validation Study

Language

eng

PubMed ID

25008902

Citation

Caceres, Diego H., et al. "Validation of an Enzyme-linked Immunosorbent Assay That Detects Histoplasma Capsulatum Antigenuria in Colombian Patients With AIDS for Diagnosis and Follow-up During Therapy." Clinical and Vaccine Immunology : CVI, vol. 21, no. 9, 2014, pp. 1364-8.
Caceres DH, Scheel CM, Tobón AM, et al. Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy. Clin Vaccine Immunol. 2014;21(9):1364-8.
Caceres, D. H., Scheel, C. M., Tobón, A. M., Ahlquist Cleveland, A., Restrepo, A., Brandt, M. E., Chiller, T., & Gómez, B. L. (2014). Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy. Clinical and Vaccine Immunology : CVI, 21(9), 1364-8. https://doi.org/10.1128/CVI.00101-14
Caceres DH, et al. Validation of an Enzyme-linked Immunosorbent Assay That Detects Histoplasma Capsulatum Antigenuria in Colombian Patients With AIDS for Diagnosis and Follow-up During Therapy. Clin Vaccine Immunol. 2014;21(9):1364-8. PubMed PMID: 25008902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy. AU - Caceres,Diego H, AU - Scheel,Christina M, AU - Tobón,Angela M, AU - Ahlquist Cleveland,Angela, AU - Restrepo,Angela, AU - Brandt,Mary E, AU - Chiller,Tom, AU - Gómez,Beatriz L, Y1 - 2014/07/09/ PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2015/9/1/medline SP - 1364 EP - 8 JF - Clinical and vaccine immunology : CVI JO - Clin Vaccine Immunol VL - 21 IS - 9 N2 - We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy. SN - 1556-679X UR - https://www.unboundmedicine.com/medline/citation/25008902/Validation_of_an_enzyme_linked_immunosorbent_assay_that_detects_Histoplasma_capsulatum_antigenuria_in_Colombian_patients_with_AIDS_for_diagnosis_and_follow_up_during_therapy_ L2 - http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=25008902 DB - PRIME DP - Unbound Medicine ER -