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Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice.
Neurosci Lett. 2014 Aug 22; 578:187-91.NL

Abstract

The nonapeptide hemopressin and its N-terminal extension VD-hemopressin(α) were reported as an antagonist/inverse agonist and an agonist of CB1 receptor, respectively. These novel cannabinoid peptides have been demonstrated to modulate the acute pain. In the present study, hemopressin (11, 22 and 45 nmol, i.c.v.) dose-dependently produced antinociception after supraspinal administration in the radiant heat tail-flick test. Furthermore, the development of antinociceptive tolerance to hemopressin, VD-hemopressin(α) and WIN55,212-2, and cross-tolerance among these cannabinoids were investigated in mice. The tolerance developed on day 4 after supraspinal injection of hemopressin (45 nmol), VD-hemopressin(α) (20 nmol) and WIN55,212-2 (7.5 nmol). Our results indicated symmetrical cross-tolerance between hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice. These results demonstrate that both hemopressin and VD-hemopressin(α) have a time-course and extent of tolerance similar to the synthetic cannabinoid WIN55,212-2. In addition, our data imply that a common mechanism is involved in the antinociception of the three cannabinoid ligands.

Authors+Show Affiliations

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China. Electronic address: fangq@lzu.edu.cn.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China. Electronic address: wangrui@lzu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25010019

Citation

Pan, Jia-Xin, et al. "Analgesic Tolerance and Cross-tolerance to the Cannabinoid Receptors Ligands Hemopressin, VD-hemopressin(α) and WIN55,212-2 at the Supraspinal Level in Mice." Neuroscience Letters, vol. 578, 2014, pp. 187-91.
Pan JX, Wang ZL, Li N, et al. Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice. Neurosci Lett. 2014;578:187-91.
Pan, J. X., Wang, Z. L., Li, N., Han, Z. L., Li, X. H., Tang, H. H., Wang, P., Zheng, T., Fang, Q., & Wang, R. (2014). Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice. Neuroscience Letters, 578, 187-91. https://doi.org/10.1016/j.neulet.2014.06.058
Pan JX, et al. Analgesic Tolerance and Cross-tolerance to the Cannabinoid Receptors Ligands Hemopressin, VD-hemopressin(α) and WIN55,212-2 at the Supraspinal Level in Mice. Neurosci Lett. 2014 Aug 22;578:187-91. PubMed PMID: 25010019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice. AU - Pan,Jia-Xin, AU - Wang,Zi-Long, AU - Li,Ning, AU - Han,Zheng-Lan, AU - Li,Xu-Hui, AU - Tang,Hong-Hai, AU - Wang,Pei, AU - Zheng,Ting, AU - Fang,Quan, AU - Wang,Rui, Y1 - 2014/07/07/ PY - 2014/05/26/received PY - 2014/06/25/revised PY - 2014/06/27/accepted PY - 2014/7/11/entrez PY - 2014/7/11/pubmed PY - 2015/4/14/medline KW - Antinociception KW - Cross-tolerance KW - Hemopressin KW - Mice KW - Tolerance KW - VD-hemopressin(α) SP - 187 EP - 91 JF - Neuroscience letters JO - Neurosci Lett VL - 578 N2 - The nonapeptide hemopressin and its N-terminal extension VD-hemopressin(α) were reported as an antagonist/inverse agonist and an agonist of CB1 receptor, respectively. These novel cannabinoid peptides have been demonstrated to modulate the acute pain. In the present study, hemopressin (11, 22 and 45 nmol, i.c.v.) dose-dependently produced antinociception after supraspinal administration in the radiant heat tail-flick test. Furthermore, the development of antinociceptive tolerance to hemopressin, VD-hemopressin(α) and WIN55,212-2, and cross-tolerance among these cannabinoids were investigated in mice. The tolerance developed on day 4 after supraspinal injection of hemopressin (45 nmol), VD-hemopressin(α) (20 nmol) and WIN55,212-2 (7.5 nmol). Our results indicated symmetrical cross-tolerance between hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice. These results demonstrate that both hemopressin and VD-hemopressin(α) have a time-course and extent of tolerance similar to the synthetic cannabinoid WIN55,212-2. In addition, our data imply that a common mechanism is involved in the antinociception of the three cannabinoid ligands. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/25010019/Analgesic_tolerance_and_cross_tolerance_to_the_cannabinoid_receptors_ligands_hemopressin_VD_hemopressin_α__and_WIN55212_2_at_the_supraspinal_level_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(14)00539-4 DB - PRIME DP - Unbound Medicine ER -