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Time course of changes in aniseikonia and foveal microstructure after vitrectomy for epiretinal membrane.
Ophthalmology. 2014 Nov; 121(11):2255-60.O

Abstract

PURPOSE

To quantify aniseikonia in patients undergoing vitrectomy for epiretinal membrane (ERM) and to investigate the relationship between the aniseikonia and the foveal microstructure by spectral-domain (SD) optical coherence tomography (OCT).

DESIGN

Prospective, consecutive, interventional case series.

SUBJECTS

This study included 44 eyes of 44 patients undergoing vitrectomy for idiopathic ERM.

METHODS

We examined visual acuity and aniseikonia using the New Aniseikonia Test and SD-OCT before and 3 and 6 months after surgery. On the basis of the obtained OCT image, we divided the 1.0 × 1.0-mm area centered on the fovea into 9 sections at 0.25-mm intervals and quantified the following parameters using an image-processing program: central foveal thickness and mean thickness of the ganglion cell layer, inner nuclear layer (INL), and outer retinal layer (outer nuclear layer + outer plexiform layer). The status of the photoreceptor inner segment/outer segment junction, external limiting membrane, and cone outer segment tips also was evaluated.

MAIN OUTCOME MEASURES

Amount of aniseikonia 6 months after surgery.

RESULTS

Of 44 patients, 39 (89%) had macropsia, 1 (2%) had micropsia, and 4 (9%) had no aniseikonia preoperatively. Mean preoperative aniseikonia was 6.2% ± 4.5%. Vitrectomy significantly improved visual acuity in patients with ERM but did not change the amount of aniseikonia. Multiple regression analysis revealed that preoperative aniseikonia at 6 months was significantly related to preoperative INL thickness, whereas postoperative aniseikonia at 6 months was associated with postoperative INL thickness at 6 months. Preoperative INL thickness was found to be of significant prognostic value for postoperative aniseikonia at 6 months.

CONCLUSIONS

Most of the patients with ERM had macropsia. Aniseikonia was not reduced after surgery. The amount of aniseikonia was associated with INL thickness.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. Electronic address: Fumiki-o@md.tsukuba.ac.jp.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25012933

Citation

Okamoto, Fumiki, et al. "Time Course of Changes in Aniseikonia and Foveal Microstructure After Vitrectomy for Epiretinal Membrane." Ophthalmology, vol. 121, no. 11, 2014, pp. 2255-60.
Okamoto F, Sugiura Y, Okamoto Y, et al. Time course of changes in aniseikonia and foveal microstructure after vitrectomy for epiretinal membrane. Ophthalmology. 2014;121(11):2255-60.
Okamoto, F., Sugiura, Y., Okamoto, Y., Hiraoka, T., & Oshika, T. (2014). Time course of changes in aniseikonia and foveal microstructure after vitrectomy for epiretinal membrane. Ophthalmology, 121(11), 2255-60. https://doi.org/10.1016/j.ophtha.2014.05.016
Okamoto F, et al. Time Course of Changes in Aniseikonia and Foveal Microstructure After Vitrectomy for Epiretinal Membrane. Ophthalmology. 2014;121(11):2255-60. PubMed PMID: 25012933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time course of changes in aniseikonia and foveal microstructure after vitrectomy for epiretinal membrane. AU - Okamoto,Fumiki, AU - Sugiura,Yoshimi, AU - Okamoto,Yoshifumi, AU - Hiraoka,Takahiro, AU - Oshika,Tetsuro, Y1 - 2014/07/08/ PY - 2014/03/15/received PY - 2014/04/22/revised PY - 2014/05/19/accepted PY - 2014/7/12/entrez PY - 2014/7/12/pubmed PY - 2015/3/27/medline SP - 2255 EP - 60 JF - Ophthalmology JO - Ophthalmology VL - 121 IS - 11 N2 - PURPOSE: To quantify aniseikonia in patients undergoing vitrectomy for epiretinal membrane (ERM) and to investigate the relationship between the aniseikonia and the foveal microstructure by spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Prospective, consecutive, interventional case series. SUBJECTS: This study included 44 eyes of 44 patients undergoing vitrectomy for idiopathic ERM. METHODS: We examined visual acuity and aniseikonia using the New Aniseikonia Test and SD-OCT before and 3 and 6 months after surgery. On the basis of the obtained OCT image, we divided the 1.0 × 1.0-mm area centered on the fovea into 9 sections at 0.25-mm intervals and quantified the following parameters using an image-processing program: central foveal thickness and mean thickness of the ganglion cell layer, inner nuclear layer (INL), and outer retinal layer (outer nuclear layer + outer plexiform layer). The status of the photoreceptor inner segment/outer segment junction, external limiting membrane, and cone outer segment tips also was evaluated. MAIN OUTCOME MEASURES: Amount of aniseikonia 6 months after surgery. RESULTS: Of 44 patients, 39 (89%) had macropsia, 1 (2%) had micropsia, and 4 (9%) had no aniseikonia preoperatively. Mean preoperative aniseikonia was 6.2% ± 4.5%. Vitrectomy significantly improved visual acuity in patients with ERM but did not change the amount of aniseikonia. Multiple regression analysis revealed that preoperative aniseikonia at 6 months was significantly related to preoperative INL thickness, whereas postoperative aniseikonia at 6 months was associated with postoperative INL thickness at 6 months. Preoperative INL thickness was found to be of significant prognostic value for postoperative aniseikonia at 6 months. CONCLUSIONS: Most of the patients with ERM had macropsia. Aniseikonia was not reduced after surgery. The amount of aniseikonia was associated with INL thickness. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/25012933/Time_course_of_changes_in_aniseikonia_and_foveal_microstructure_after_vitrectomy_for_epiretinal_membrane_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(14)00452-7 DB - PRIME DP - Unbound Medicine ER -