Tags

Type your tag names separated by a space and hit enter

Association of body mass index with all-cause and cardiovascular disease mortality in the elderly.
PLoS One. 2014; 9(7):e102589.Plos

Abstract

OBJECTIVES

To evaluate the associations of body mass index (BMI) with all-cause, cardiovascular disease (CVD), and expanded CVD mortality in the elderly.

DESIGN

Observational cohort study.

SETTING

Annual physical examination program for the elderly from 2006 to 2010.

PARTICIPANTS

We included 77,541 Taipei residents aged ≥ 65 years (39,365 men and 38,176 women).

MEASUREMENTS

BMI was categorized as underweight (BMI<18.5), normal weight (18.5 ≤ BMI<25), overweight (25 ≤ BMI<30), grade 1 obesity (30 ≤ BMI<35), or grade 2-3 obesity (BMI ≥ 35). Mortality was ascertained by national death files.

RESULTS

Underweight (hazard ratios [HRs] of all-cause, CVD, and expanded CVD mortality: 1.92, 1.74, and 1.77, respectively), grade 2-3 obesity (HRs: 1.59, 2.36, and 2.22, respectively), older age, male sex, smoking, and high fasting blood sugar were significant predictors of mortality. Meanwhile, being married/cohabitating, higher education, alcohol consumption, more regular exercise, and high total cholesterol were inversely associated with mortality. Multivariate stratified subgroup analyses verified smokers (HRs of all-cause, CVD, and expanded CVD mortality: 3.25, 10.71, and 7.86, respectively, for grade 2-3 obesity), the high triglyceride group (HRs: 5.82, 10.99, and 14.22, respectively for underweight), and patients with 3-4 factors related to metabolic syndrome (HRs: 4.86, 12.72, and 11.42, respectively, for underweight) were associated with mortality.

CONCLUSION

The associations of BMI with all-cause, CVD, expanded CVD mortality in the elderly are represented by U-shaped curves, suggesting unilateral promotions or interventions in weight reduction in the elderly may be inappropriate. Heterogeneous effects of grades 1 and 2-3 obesity on mortality were observed and should be treated as different levels of obesity.

Authors+Show Affiliations

Institute of Public Health, National Yang Ming University, Taipei, Taiwan; Department of Dermatology, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.Institute of Public Health, National Yang Ming University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.Department of Education and Research, Taipei City Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.Institute of Public Health, National Yang Ming University, Taipei, Taiwan.Institute of Public Health, National Yang Ming University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University School of Medicine, Taipei, Taiwan.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25014070

Citation

Wu, Chen-Yi, et al. "Association of Body Mass Index With All-cause and Cardiovascular Disease Mortality in the Elderly." PloS One, vol. 9, no. 7, 2014, pp. e102589.
Wu CY, Chou YC, Huang N, et al. Association of body mass index with all-cause and cardiovascular disease mortality in the elderly. PLoS One. 2014;9(7):e102589.
Wu, C. Y., Chou, Y. C., Huang, N., Chou, Y. J., Hu, H. Y., & Li, C. P. (2014). Association of body mass index with all-cause and cardiovascular disease mortality in the elderly. PloS One, 9(7), e102589. https://doi.org/10.1371/journal.pone.0102589
Wu CY, et al. Association of Body Mass Index With All-cause and Cardiovascular Disease Mortality in the Elderly. PLoS One. 2014;9(7):e102589. PubMed PMID: 25014070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of body mass index with all-cause and cardiovascular disease mortality in the elderly. AU - Wu,Chen-Yi, AU - Chou,Yi-Chang, AU - Huang,Nicole, AU - Chou,Yiing-Jenq, AU - Hu,Hsiao-Yun, AU - Li,Chung-Pin, Y1 - 2014/07/11/ PY - 2013/12/16/received PY - 2014/06/20/accepted PY - 2014/7/12/entrez PY - 2014/7/12/pubmed PY - 2015/3/5/medline SP - e102589 EP - e102589 JF - PloS one JO - PLoS One VL - 9 IS - 7 N2 - OBJECTIVES: To evaluate the associations of body mass index (BMI) with all-cause, cardiovascular disease (CVD), and expanded CVD mortality in the elderly. DESIGN: Observational cohort study. SETTING: Annual physical examination program for the elderly from 2006 to 2010. PARTICIPANTS: We included 77,541 Taipei residents aged ≥ 65 years (39,365 men and 38,176 women). MEASUREMENTS: BMI was categorized as underweight (BMI<18.5), normal weight (18.5 ≤ BMI<25), overweight (25 ≤ BMI<30), grade 1 obesity (30 ≤ BMI<35), or grade 2-3 obesity (BMI ≥ 35). Mortality was ascertained by national death files. RESULTS: Underweight (hazard ratios [HRs] of all-cause, CVD, and expanded CVD mortality: 1.92, 1.74, and 1.77, respectively), grade 2-3 obesity (HRs: 1.59, 2.36, and 2.22, respectively), older age, male sex, smoking, and high fasting blood sugar were significant predictors of mortality. Meanwhile, being married/cohabitating, higher education, alcohol consumption, more regular exercise, and high total cholesterol were inversely associated with mortality. Multivariate stratified subgroup analyses verified smokers (HRs of all-cause, CVD, and expanded CVD mortality: 3.25, 10.71, and 7.86, respectively, for grade 2-3 obesity), the high triglyceride group (HRs: 5.82, 10.99, and 14.22, respectively for underweight), and patients with 3-4 factors related to metabolic syndrome (HRs: 4.86, 12.72, and 11.42, respectively, for underweight) were associated with mortality. CONCLUSION: The associations of BMI with all-cause, CVD, expanded CVD mortality in the elderly are represented by U-shaped curves, suggesting unilateral promotions or interventions in weight reduction in the elderly may be inappropriate. Heterogeneous effects of grades 1 and 2-3 obesity on mortality were observed and should be treated as different levels of obesity. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25014070/Association_of_body_mass_index_with_all_cause_and_cardiovascular_disease_mortality_in_the_elderly_ L2 - https://dx.plos.org/10.1371/journal.pone.0102589 DB - PRIME DP - Unbound Medicine ER -