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Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.

Abstract

BACKGROUND

Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absorption and bioactivity, and bioconversion diminishes the toxicity of red ginseng's metabolite. This study was conducted to investigate the effects of daily supplementation with fermented red ginseng (FRG) on glycemic status in subjects with impaired fasting glucose or type 2 diabetes.

METHODS

This study was a four-week long, randomized, double-blind, placebo-controlled trial. Forty-two subjects with impaired fasting glucose or type 2 diabetes were randomly allocated to two groups assigned to consume either the placebo or fermented red ginseng (FRG) three times per day for four weeks. Fasting and postprandial glucose profiles during meal tolerance tests were assessed before and after the intervention.

RESULTS

FRG supplementation led to a significant reduction in postprandial glucose levels and led to an increase in postprandial insulin levels compared to the placebo group. There was a consistently significant improvement in the glucose area under the curve (AUC) in the FRG group. However, fasting glucose, insulin, and lipid profiles were not different from the placebo group.

CONCLUSION

Daily supplementation with FRG lowered postprandial glucose levels in subjects with impaired fasting glucose or type 2 diabetes.

TRIAL REGISTRATION

ClinicalTrials.gov: NCT01826409.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableClinical Trial Center for Functional Food, Chonbuk National University Hospital, 20 Geonji-ro, Jeonju, Jeonbuk 561-712, Republic of Korea. pts@jbnu.ac.kr.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25015735

Citation

Oh, Mi-Ra, et al. "Postprandial Glucose-lowering Effects of Fermented Red Ginseng in Subjects With Impaired Fasting Glucose or Type 2 Diabetes: a Randomized, Double-blind, Placebo-controlled Clinical Trial." BMC Complementary and Alternative Medicine, vol. 14, 2014, p. 237.
Oh MR, Park SH, Kim SY, et al. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med. 2014;14:237.
Oh, M. R., Park, S. H., Kim, S. Y., Back, H. I., Kim, M. G., Jeon, J. Y., ... Chae, S. W. (2014). Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. BMC Complementary and Alternative Medicine, 14, p. 237. doi:10.1186/1472-6882-14-237.
Oh MR, et al. Postprandial Glucose-lowering Effects of Fermented Red Ginseng in Subjects With Impaired Fasting Glucose or Type 2 Diabetes: a Randomized, Double-blind, Placebo-controlled Clinical Trial. BMC Complement Altern Med. 2014 Jul 11;14:237. PubMed PMID: 25015735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. AU - Oh,Mi-Ra, AU - Park,Soo-Hyun, AU - Kim,Sun-Young, AU - Back,Hyang-Im, AU - Kim,Min-Gul, AU - Jeon,Ji-Young, AU - Ha,Ki-Chan, AU - Na,Won-Taek, AU - Cha,Youn-Soo, AU - Park,Byung-Hyun, AU - Park,Tae-sun, AU - Chae,Soo-Wan, Y1 - 2014/07/11/ PY - 2013/09/23/received PY - 2014/07/03/accepted PY - 2014/7/13/entrez PY - 2014/7/13/pubmed PY - 2014/11/15/medline SP - 237 EP - 237 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 14 N2 - BACKGROUND: Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absorption and bioactivity, and bioconversion diminishes the toxicity of red ginseng's metabolite. This study was conducted to investigate the effects of daily supplementation with fermented red ginseng (FRG) on glycemic status in subjects with impaired fasting glucose or type 2 diabetes. METHODS: This study was a four-week long, randomized, double-blind, placebo-controlled trial. Forty-two subjects with impaired fasting glucose or type 2 diabetes were randomly allocated to two groups assigned to consume either the placebo or fermented red ginseng (FRG) three times per day for four weeks. Fasting and postprandial glucose profiles during meal tolerance tests were assessed before and after the intervention. RESULTS: FRG supplementation led to a significant reduction in postprandial glucose levels and led to an increase in postprandial insulin levels compared to the placebo group. There was a consistently significant improvement in the glucose area under the curve (AUC) in the FRG group. However, fasting glucose, insulin, and lipid profiles were not different from the placebo group. CONCLUSION: Daily supplementation with FRG lowered postprandial glucose levels in subjects with impaired fasting glucose or type 2 diabetes. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01826409. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/25015735/Postprandial_glucose_lowering_effects_of_fermented_red_ginseng_in_subjects_with_impaired_fasting_glucose_or_type_2_diabetes:_a_randomized_double_blind_placebo_controlled_clinical_trial_ L2 - https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-237 DB - PRIME DP - Unbound Medicine ER -