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A multi-biomarker risk assessment of the impact of brominated flame retardant-decabromodiphenyl ether (BDE209) on the antioxidant system of earthworm Eisenia fetida.
Environ Toxicol Pharmacol. 2014 Jul; 38(1):297-304.ET

Abstract

Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor incubation tests were performed systematically on control and contaminated soil samples to determine the effects of BDE209 on the antioxidant system of earthworm Eisenia fetida. The results showed that compared to the controls, superoxide dismutase (SOD) activities in all treated groups were elevated significantly after 21 and 28 days exposure; catalase (CAT) activities were much higher in all tests during the entire exposure period; peroxidase (POD) and glutathione-s-transferase (GST) activities generally decreased and indicated contrary response trend; the total antioxidant capacity (T-AOC) after exposure to low level of BDE209 (1 mg kg(-1)) was induced, whereas at 10 and 100 mg kg(-1) concentrations it showed suppression status; electron paramagnetic resonance (EPR) spectra suggested that hydroxyl radicals (OH) in earthworms were significantly induced by BDE209; the changes in malondialdehyde (MDA) contents suggested that reactive oxygen species (ROS) might lead to cellular lipid peroxidation in earthworms. The results of these observations suggested that severe oxidative stress occurred in E. fetida, and it may play an important role in inducing the BDE209 toxicity to earthworms.

Authors+Show Affiliations

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, Shanghai 200237, China; School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: wzhang@ecust.edu.cn.State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, Shanghai 200237, China; School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China.Shanghai Fisheries Research Institute, Shanghai 200433, China.State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, Shanghai 200237, China; School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China.State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, Shanghai 200237, China; School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China.Shanghai Academy of Environmental Sciences, Shanghai 200233, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25016100

Citation

Zhang, Wei, et al. "A Multi-biomarker Risk Assessment of the Impact of Brominated Flame Retardant-decabromodiphenyl Ether (BDE209) On the Antioxidant System of Earthworm Eisenia Fetida." Environmental Toxicology and Pharmacology, vol. 38, no. 1, 2014, pp. 297-304.
Zhang W, Liu K, Chen L, et al. A multi-biomarker risk assessment of the impact of brominated flame retardant-decabromodiphenyl ether (BDE209) on the antioxidant system of earthworm Eisenia fetida. Environ Toxicol Pharmacol. 2014;38(1):297-304.
Zhang, W., Liu, K., Chen, L., Chen, L., Lin, K., & Fu, R. (2014). A multi-biomarker risk assessment of the impact of brominated flame retardant-decabromodiphenyl ether (BDE209) on the antioxidant system of earthworm Eisenia fetida. Environmental Toxicology and Pharmacology, 38(1), 297-304. https://doi.org/10.1016/j.etap.2014.06.007
Zhang W, et al. A Multi-biomarker Risk Assessment of the Impact of Brominated Flame Retardant-decabromodiphenyl Ether (BDE209) On the Antioxidant System of Earthworm Eisenia Fetida. Environ Toxicol Pharmacol. 2014;38(1):297-304. PubMed PMID: 25016100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A multi-biomarker risk assessment of the impact of brominated flame retardant-decabromodiphenyl ether (BDE209) on the antioxidant system of earthworm Eisenia fetida. AU - Zhang,Wei, AU - Liu,Kou, AU - Chen,Lin, AU - Chen,Lei, AU - Lin,Kuangfei, AU - Fu,Rongbing, Y1 - 2014/06/26/ PY - 2014/05/09/received PY - 2014/06/17/revised PY - 2014/06/19/accepted PY - 2014/7/13/entrez PY - 2014/7/13/pubmed PY - 2015/4/14/medline KW - Antioxidant enzymes KW - BDE209 KW - Eisenia fetida KW - Hydroxyl radical KW - Lipid peroxidation SP - 297 EP - 304 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 38 IS - 1 N2 - Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor incubation tests were performed systematically on control and contaminated soil samples to determine the effects of BDE209 on the antioxidant system of earthworm Eisenia fetida. The results showed that compared to the controls, superoxide dismutase (SOD) activities in all treated groups were elevated significantly after 21 and 28 days exposure; catalase (CAT) activities were much higher in all tests during the entire exposure period; peroxidase (POD) and glutathione-s-transferase (GST) activities generally decreased and indicated contrary response trend; the total antioxidant capacity (T-AOC) after exposure to low level of BDE209 (1 mg kg(-1)) was induced, whereas at 10 and 100 mg kg(-1) concentrations it showed suppression status; electron paramagnetic resonance (EPR) spectra suggested that hydroxyl radicals (OH) in earthworms were significantly induced by BDE209; the changes in malondialdehyde (MDA) contents suggested that reactive oxygen species (ROS) might lead to cellular lipid peroxidation in earthworms. The results of these observations suggested that severe oxidative stress occurred in E. fetida, and it may play an important role in inducing the BDE209 toxicity to earthworms. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/25016100/A_multi_biomarker_risk_assessment_of_the_impact_of_brominated_flame_retardant_decabromodiphenyl_ether__BDE209__on_the_antioxidant_system_of_earthworm_Eisenia_fetida_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(14)00150-1 DB - PRIME DP - Unbound Medicine ER -