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Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury.
Exp Clin Transplant. 2015 Feb; 13(1):100-5.EC

Abstract

OBJECTIVES

In dogs with deep analgesia caused by acute spinal cord injury from thoracolumbar disk herniation, autologous bone marrow mononuclear cell transplant may improve recovery. The purpose of the present study was to evaluate autologous bone marrow mononuclear cell transplant in a dog that had paraplegia and deep analgesia caused by chronic spinal cord injury.

MATERIALS AND METHODS

Autologous bone marrow mononuclear cell transplant was performed in a dog having paraplegia and analgesia for 3 years that was caused by a chronic spinal cord injury secondary to Hansen type I thoracolumbar disk herniation. Functional recovery was evaluated with electrophysiologic studies and the Texas Spinal Cord Injury Scale.

RESULTS

Somatosensory evoked potentials were absent before transplant but were detected after transplant. Functional improvement was noted (Texas Spinal Cord Injury Scale: before transplant, 0; after transplant, 6). No adverse events were observed.

CONCLUSIONS

Autologous bone marrow mononuclear cell transplant into the subarachnoid space may be a safe and beneficial treatment for chronic spinal cord injury in dogs.

Authors+Show Affiliations

From the Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto; and the Aikouishida Animal Hospital, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25019162

Citation

Tamura, Katsutoshi, et al. "Autologous Bone Marrow Mononuclear Cell Transplant and Surgical Decompression in a Dog With Chronic Spinal Cord Injury." Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation, vol. 13, no. 1, 2015, pp. 100-5.
Tamura K, Harada Y, Kunimi M, et al. Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury. Exp Clin Transplant. 2015;13(1):100-5.
Tamura, K., Harada, Y., Kunimi, M., Takemitsu, H., Hara, Y., Nakamura, T., & Tagawa, M. (2015). Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury. Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation, 13(1), 100-5. https://doi.org/10.6002/ect.2013.0237
Tamura K, et al. Autologous Bone Marrow Mononuclear Cell Transplant and Surgical Decompression in a Dog With Chronic Spinal Cord Injury. Exp Clin Transplant. 2015;13(1):100-5. PubMed PMID: 25019162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury. AU - Tamura,Katsutoshi, AU - Harada,Yasuji, AU - Kunimi,Maki, AU - Takemitsu,Hiroshi, AU - Hara,Yasushi, AU - Nakamura,Tatsuo, AU - Tagawa,Masahiro, Y1 - 2014/06/25/ PY - 2014/7/15/entrez PY - 2014/7/16/pubmed PY - 2015/10/31/medline SP - 100 EP - 5 JF - Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation JO - Exp Clin Transplant VL - 13 IS - 1 N2 - OBJECTIVES: In dogs with deep analgesia caused by acute spinal cord injury from thoracolumbar disk herniation, autologous bone marrow mononuclear cell transplant may improve recovery. The purpose of the present study was to evaluate autologous bone marrow mononuclear cell transplant in a dog that had paraplegia and deep analgesia caused by chronic spinal cord injury. MATERIALS AND METHODS: Autologous bone marrow mononuclear cell transplant was performed in a dog having paraplegia and analgesia for 3 years that was caused by a chronic spinal cord injury secondary to Hansen type I thoracolumbar disk herniation. Functional recovery was evaluated with electrophysiologic studies and the Texas Spinal Cord Injury Scale. RESULTS: Somatosensory evoked potentials were absent before transplant but were detected after transplant. Functional improvement was noted (Texas Spinal Cord Injury Scale: before transplant, 0; after transplant, 6). No adverse events were observed. CONCLUSIONS: Autologous bone marrow mononuclear cell transplant into the subarachnoid space may be a safe and beneficial treatment for chronic spinal cord injury in dogs. SN - 2146-8427 UR - https://www.unboundmedicine.com/medline/citation/25019162/Autologous_bone_marrow_mononuclear_cell_transplant_and_surgical_decompression_in_a_dog_with_chronic_spinal_cord_injury_ L2 - http://www.ectrx.org/forms/ectrxcontentshow.php?year=2015&volume=13&issue=1&supplement=0&makale_no=0&spage_number=100&content_type=FULL TEXT DB - PRIME DP - Unbound Medicine ER -