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Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.
Chem Commun (Camb). 2014 Oct 14; 50(80):11788-805.CC

Abstract

Hydrogen sulfide (H2S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H2S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H2S in the future. Hydrogen sulfide releasing agents (also known as H2S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H2S and to be aware of the limitations associated with the choice of donors used to generate H2S in vitro and in vivo. In this review we summarized the developments and limitations of currently available donors including H2S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.

Authors+Show Affiliations

Department of Chemistry, Washington State University, Pullman, WA 99164, USA. mxian@wsu.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25019301

Citation

Zhao, Yu, et al. "Hydrogen Sulfide (H2S) Releasing Agents: Chemistry and Biological Applications." Chemical Communications (Cambridge, England), vol. 50, no. 80, 2014, pp. 11788-805.
Zhao Y, Biggs TD, Xian M. Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications. Chem Commun (Camb). 2014;50(80):11788-805.
Zhao, Y., Biggs, T. D., & Xian, M. (2014). Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications. Chemical Communications (Cambridge, England), 50(80), 11788-805. https://doi.org/10.1039/c4cc00968a
Zhao Y, Biggs TD, Xian M. Hydrogen Sulfide (H2S) Releasing Agents: Chemistry and Biological Applications. Chem Commun (Camb). 2014 Oct 14;50(80):11788-805. PubMed PMID: 25019301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications. AU - Zhao,Yu, AU - Biggs,Tyler D, AU - Xian,Ming, PY - 2014/7/15/entrez PY - 2014/7/16/pubmed PY - 2015/5/21/medline SP - 11788 EP - 805 JF - Chemical communications (Cambridge, England) JO - Chem. Commun. (Camb.) VL - 50 IS - 80 N2 - Hydrogen sulfide (H2S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H2S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H2S in the future. Hydrogen sulfide releasing agents (also known as H2S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H2S and to be aware of the limitations associated with the choice of donors used to generate H2S in vitro and in vivo. In this review we summarized the developments and limitations of currently available donors including H2S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/25019301/Hydrogen_sulfide__H2S__releasing_agents:_chemistry_and_biological_applications_ L2 - https://doi.org/10.1039/c4cc00968a DB - PRIME DP - Unbound Medicine ER -