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Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression.
J Med Food. 2014 Sep; 17(9):985-95.JM

Abstract

Ultraviolet (UV) radiation causes photodamage to the skin, which, in turn, leads to depletion of the dermal extracellular matrix and chronic alterations in skin structure. Skin wrinkles are associated with collagen synthesis and matrix metalloproteinase-1 (MMP-1) activity. Coriandrum sativum L. (coriander leaf, cilantro; CS) has been used as a herbal medicine for the treatment of diabetes, hyperlipidemia, liver disease, and cancer. In this study, we examined whether CS ethanol extract (CSE) has protective effects against UVB-induced skin photoaging in normal human dermal fibroblasts (NHDF) in vitro and in the skin of hairless mice in vivo. The main component of CSE, linolenic acid, was determined by gas chromatography-mass spectroscopy. We measured the cellular levels of procollagen type I and MMP-1 using ELISA in NHDF cells after UVB irradiation. NHDF cells that were treated with CSE after UVB irradiation exhibited higher procollagen type I production and lower levels of MMP-1 than untreated cells. We found that the activity of transcription factor activator protein-1 (AP-1) was also inhibited by CSE treatment. We measured the epidermal thickness, dermal collagen fiber density, and procollagen type I and MMP-1 levels in photo-aged mouse skin in vivo using histological staining and western blot analysis. Our results showed that CSE-treated mice had thinner epidermal layers and denser dermal collagen fibers than untreated mice. On a molecular level, it was further confirmed that CSE-treated mice had lower MMP-1 levels and higher procollagen type I levels than untreated mice. Our results support the potential of C. sativum L. to prevent skin photoaging.

Authors+Show Affiliations

1 Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University , Yongin-Si, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25019675

Citation

Hwang, Eunson, et al. "Coriander Leaf Extract Exerts Antioxidant Activity and Protects Against UVB-induced Photoaging of Skin By Regulation of Procollagen Type I and MMP-1 Expression." Journal of Medicinal Food, vol. 17, no. 9, 2014, pp. 985-95.
Hwang E, Lee DG, Park SH, et al. Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. J Med Food. 2014;17(9):985-95.
Hwang, E., Lee, D. G., Park, S. H., Oh, M. S., & Kim, S. Y. (2014). Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. Journal of Medicinal Food, 17(9), 985-95. https://doi.org/10.1089/jmf.2013.2999
Hwang E, et al. Coriander Leaf Extract Exerts Antioxidant Activity and Protects Against UVB-induced Photoaging of Skin By Regulation of Procollagen Type I and MMP-1 Expression. J Med Food. 2014;17(9):985-95. PubMed PMID: 25019675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. AU - Hwang,Eunson, AU - Lee,Do-Gyeong, AU - Park,Sin Hee, AU - Oh,Myung Sook, AU - Kim,Sun Yeou, Y1 - 2014/07/14/ PY - 2014/7/15/entrez PY - 2014/7/16/pubmed PY - 2015/5/13/medline KW - Coriandrum sativum KW - MMP-1 KW - UVB KW - hairless mice KW - procollagen type I SP - 985 EP - 95 JF - Journal of medicinal food JO - J Med Food VL - 17 IS - 9 N2 - Ultraviolet (UV) radiation causes photodamage to the skin, which, in turn, leads to depletion of the dermal extracellular matrix and chronic alterations in skin structure. Skin wrinkles are associated with collagen synthesis and matrix metalloproteinase-1 (MMP-1) activity. Coriandrum sativum L. (coriander leaf, cilantro; CS) has been used as a herbal medicine for the treatment of diabetes, hyperlipidemia, liver disease, and cancer. In this study, we examined whether CS ethanol extract (CSE) has protective effects against UVB-induced skin photoaging in normal human dermal fibroblasts (NHDF) in vitro and in the skin of hairless mice in vivo. The main component of CSE, linolenic acid, was determined by gas chromatography-mass spectroscopy. We measured the cellular levels of procollagen type I and MMP-1 using ELISA in NHDF cells after UVB irradiation. NHDF cells that were treated with CSE after UVB irradiation exhibited higher procollagen type I production and lower levels of MMP-1 than untreated cells. We found that the activity of transcription factor activator protein-1 (AP-1) was also inhibited by CSE treatment. We measured the epidermal thickness, dermal collagen fiber density, and procollagen type I and MMP-1 levels in photo-aged mouse skin in vivo using histological staining and western blot analysis. Our results showed that CSE-treated mice had thinner epidermal layers and denser dermal collagen fibers than untreated mice. On a molecular level, it was further confirmed that CSE-treated mice had lower MMP-1 levels and higher procollagen type I levels than untreated mice. Our results support the potential of C. sativum L. to prevent skin photoaging. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/25019675/Coriander_leaf_extract_exerts_antioxidant_activity_and_protects_against_UVB_induced_photoaging_of_skin_by_regulation_of_procollagen_type_I_and_MMP_1_expression_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2013.2999?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -