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Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome.
Eur J Obstet Gynecol Reprod Biol. 2014 Sep; 180:56-60.EJ

Abstract

OBJECTIVE

The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).

STUDY DESIGN

The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI≥25 kg/m(2)) and normal weight. (BMI<25 kg/m(2)) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured.

RESULTS

Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p<0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p<0.05). When overweight or obese (BMI≥25 kg/m(2)) and normal weight (BMI<25 kg/m(2)) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p<0.05, respectively).

CONCLUSIONS

These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Yilmaz SA
Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey. Electronic address: setenayarzu@hotmail.com.
Kerimoglu OS
Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
Pekin AT
Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
Incesu F
Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
Dogan NU
Department of Obstetrics and Gynecology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
Celik C
Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
Unlu A
Department of Biochemistry, Selcuk University, Faculty of Medicine, Konya, Turkey.

MeSH

AdolescentAdultBlood GlucoseCase-Control StudiesDehydroepiandrosterone SulfateFemaleFollicle Stimulating HormoneHirsutismHumansInsulin ResistanceKisspeptinsLipidsLuteinizing HormoneObesityOverweightPolycystic Ovary SyndromeProlactinSex Hormone-Binding GlobulinTestosteroneThyrotropinYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25020276

Citation

Yilmaz, S A., et al. "Metastin Levels in Relation With Hormonal and Metabolic Profile in Patients With Polycystic Ovary Syndrome." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 180, 2014, pp. 56-60.
Yilmaz SA, Kerimoglu OS, Pekin AT, et al. Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2014;180:56-60.
Yilmaz, S. A., Kerimoglu, O. S., Pekin, A. T., Incesu, F., Dogan, N. U., Celik, C., & Unlu, A. (2014). Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 180, 56-60. https://doi.org/10.1016/j.ejogrb.2014.06.004
Yilmaz SA, et al. Metastin Levels in Relation With Hormonal and Metabolic Profile in Patients With Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2014;180:56-60. PubMed PMID: 25020276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome. AU - Yilmaz,S A, AU - Kerimoglu,O S, AU - Pekin,A T, AU - Incesu,F, AU - Dogan,N U, AU - Celik,C, AU - Unlu,A, Y1 - 2014/06/13/ PY - 2014/02/13/received PY - 2014/04/29/revised PY - 2014/06/04/accepted PY - 2014/7/15/entrez PY - 2014/7/16/pubmed PY - 2016/3/30/medline KW - Insulin resistance KW - Kisspeptin KW - Metastin KW - PCOS SP - 56 EP - 60 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 180 N2 - OBJECTIVE: The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS). STUDY DESIGN: The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI≥25 kg/m(2)) and normal weight. (BMI<25 kg/m(2)) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured. RESULTS: Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p<0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p<0.05). When overweight or obese (BMI≥25 kg/m(2)) and normal weight (BMI<25 kg/m(2)) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p<0.05, respectively). CONCLUSIONS: These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/25020276/Metastin_levels_in_relation_with_hormonal_and_metabolic_profile_in_patients_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -