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Imaging of functional and structural alterations of large arteries after acute ischaemic atherothrombotic stroke or acute coronary syndromes.
Arch Cardiovasc Dis. 2014 Aug-Sep; 107(8-9):443-51.AC

Abstract

BACKGROUND

Non-invasive methods allow the evaluation of structural and functional arterial abnormalities. So far, no study has focused on the comparison of vascular parameters by type of cardiovascular event.

METHODS

In this pilot study, cardiovascular risk factors, carotid parameters, carotid-to-femoral pulse wave velocity (PWV), brachial flow-mediated dilation and ambulatory blood pressure were assessed in patients who presented with acute coronary syndromes (ACS) or ischaemic atherothrombotic stroke (IAS). Groups were matched for age and gender.

RESULTS

Prevalences of hypertension, diabetes and dyslipidaemia and heredity, smoking and body mass index were similar in the ACS (n=50) and IAS (n=50) groups. Carotid intima-media thickness (IMT) and PWV were significantly higher in the IAS vs. ACS group (769±180 vs. 701±136 μm; P=0.039 and 12.5±3.5 vs. 10.7±2.4 m/s; P=0.006). Carotid distensibility was significantly lower in the IAS vs. ACS group (16.2±3.2 vs. 18.9±7.6 10(-3)/kPa; P=0.02). These differences persisted after adjustment for blood pressure for carotid distensibility but not for PWV. The prevalences of endothelial dysfunction and carotid plaques were not significantly different in the ACS and IAS groups (86% and 74%; 80% and 78%). In a multivariable model, carotid distensibility remained associated with ACS (odds ratio 1.19; 95% confidence interval 1.03-1.38; P=0.016).

CONCLUSIONS

Stiffness and carotid wall thickness were higher in IAS than in ACS patients. These differences may support the interest in new therapeutic targets for cardiovascular secondary prevention.

NCT NO

NCT00926874.

Authors+Show Affiliations

Department of Cardiology, University Hospital, Grenoble, France; INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble, France. Electronic address: GBarone@chu-grenoble.fr.Department of Cardiology, University Hospital, Grenoble, France; INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble, France.Department of Neurology (Stroke Unit), University Hospital, Grenoble, France.Clinical Research Center INSERM CIC03, University Hospital, Grenoble, France.Department of Neurology (Stroke Unit), University Hospital, Grenoble, France.Department of Cardiology, University Hospital, Grenoble, France.Department of Cardiology, University Hospital, Grenoble, France; INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble, France.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25023004

Citation

Barone-Rochette, Gilles, et al. "Imaging of Functional and Structural Alterations of Large Arteries After Acute Ischaemic Atherothrombotic Stroke or Acute Coronary Syndromes." Archives of Cardiovascular Diseases, vol. 107, no. 8-9, 2014, pp. 443-51.
Barone-Rochette G, Vanzetto G, Detante O, et al. Imaging of functional and structural alterations of large arteries after acute ischaemic atherothrombotic stroke or acute coronary syndromes. Arch Cardiovasc Dis. 2014;107(8-9):443-51.
Barone-Rochette, G., Vanzetto, G., Detante, O., Quesada, J. L., Hommel, M., Mallion, J. M., & Baguet, J. P. (2014). Imaging of functional and structural alterations of large arteries after acute ischaemic atherothrombotic stroke or acute coronary syndromes. Archives of Cardiovascular Diseases, 107(8-9), 443-51. https://doi.org/10.1016/j.acvd.2014.05.007
Barone-Rochette G, et al. Imaging of Functional and Structural Alterations of Large Arteries After Acute Ischaemic Atherothrombotic Stroke or Acute Coronary Syndromes. Arch Cardiovasc Dis. 2014 Aug-Sep;107(8-9):443-51. PubMed PMID: 25023004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imaging of functional and structural alterations of large arteries after acute ischaemic atherothrombotic stroke or acute coronary syndromes. AU - Barone-Rochette,Gilles, AU - Vanzetto,Gerald, AU - Detante,Olivier, AU - Quesada,Jean-Louis, AU - Hommel,Marc, AU - Mallion,Jean-Michel, AU - Baguet,Jean-Philippe, Y1 - 2014/07/10/ PY - 2013/06/28/received PY - 2014/03/23/revised PY - 2014/05/12/accepted PY - 2014/7/16/entrez PY - 2014/7/16/pubmed PY - 2015/5/15/medline KW - Accident vasculaire cérébral KW - Acute coronary syndromes KW - Brachial flow-mediated dilatation KW - Carotid-to-femoral pulse wave velocity KW - Dilatation de l’artère humérale médiée par le flux KW - Intima-media thickness KW - L’épaisseur intima-média KW - Stroke KW - Syndrome coronarien aigu KW - Vitesse de l’onde pouls SP - 443 EP - 51 JF - Archives of cardiovascular diseases JO - Arch Cardiovasc Dis VL - 107 IS - 8-9 N2 - BACKGROUND: Non-invasive methods allow the evaluation of structural and functional arterial abnormalities. So far, no study has focused on the comparison of vascular parameters by type of cardiovascular event. METHODS: In this pilot study, cardiovascular risk factors, carotid parameters, carotid-to-femoral pulse wave velocity (PWV), brachial flow-mediated dilation and ambulatory blood pressure were assessed in patients who presented with acute coronary syndromes (ACS) or ischaemic atherothrombotic stroke (IAS). Groups were matched for age and gender. RESULTS: Prevalences of hypertension, diabetes and dyslipidaemia and heredity, smoking and body mass index were similar in the ACS (n=50) and IAS (n=50) groups. Carotid intima-media thickness (IMT) and PWV were significantly higher in the IAS vs. ACS group (769±180 vs. 701±136 μm; P=0.039 and 12.5±3.5 vs. 10.7±2.4 m/s; P=0.006). Carotid distensibility was significantly lower in the IAS vs. ACS group (16.2±3.2 vs. 18.9±7.6 10(-3)/kPa; P=0.02). These differences persisted after adjustment for blood pressure for carotid distensibility but not for PWV. The prevalences of endothelial dysfunction and carotid plaques were not significantly different in the ACS and IAS groups (86% and 74%; 80% and 78%). In a multivariable model, carotid distensibility remained associated with ACS (odds ratio 1.19; 95% confidence interval 1.03-1.38; P=0.016). CONCLUSIONS: Stiffness and carotid wall thickness were higher in IAS than in ACS patients. These differences may support the interest in new therapeutic targets for cardiovascular secondary prevention. NCT NO: NCT00926874. SN - 1875-2128 UR - https://www.unboundmedicine.com/medline/citation/25023004/Imaging_of_functional_and_structural_alterations_of_large_arteries_after_acute_ischaemic_atherothrombotic_stroke_or_acute_coronary_syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-2136(14)00128-4 DB - PRIME DP - Unbound Medicine ER -