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Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis.

Abstract

BACKGROUND/OBJECTIVE

We examine whether midlife vascular risk factors (VRFs) are associated with increased risk of incident Alzheimer's disease (AD) in a systematic review and meta-analysis of published cohort studies.

METHODS

Original cohort studies were included if they reported adjusted combined odds ratio (COR) and corresponding 95% confidence intervals (CIs) or enough information to quantify the association between risk for AD in late-life and baseline VRFs of midlife.

RESULTS

There were positive and significant associations between high blood pressure (COR 1.31; 95% CI: 1.01-1.70), hypercholesterolemia (COR 1.72; 95% CI: 1.32-2.24), obesity (COR 1.88; 95% CI: 1.32-2.69), and diabetes mellitus in midlife (COR 1.4; 95% CI: 1.25-1.57). Smoking and hyperhomocysteinemia (although only one high-quality paper) were also associated with an increased risk of AD generally.

CONCLUSIONS

These results strengthen the epidemiological evidence that VRFs of midlife significantly increase risk for AD.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.

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    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.

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    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China.

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    Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.

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    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.

    ,

    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.

    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.

    Source

    MeSH

    Alzheimer Disease
    Cerebrovascular Disorders
    Humans
    Middle Aged
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    25024338

    Citation

    TY - JOUR T1 - Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis. AU - Meng,Xiang-Fei, AU - Yu,Jin-Tai, AU - Wang,Hui-Fu, AU - Tan,Meng-Shan, AU - Wang,Chong, AU - Tan,Chen-Chen, AU - Tan,Lan, PY - 2014/7/16/entrez PY - 2014/7/16/pubmed PY - 2015/7/24/medline KW - Alzheimer's disease KW - diabetes mellitus KW - high blood pressure KW - hypercholesterolemia KW - hyperhomocysteinemia KW - meta-analysis KW - midlife vascular risk factors KW - obesity KW - smoking KW - systematic review SP - 1295 EP - 310 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 42 IS - 4 N2 - BACKGROUND/OBJECTIVE: We examine whether midlife vascular risk factors (VRFs) are associated with increased risk of incident Alzheimer's disease (AD) in a systematic review and meta-analysis of published cohort studies. METHODS: Original cohort studies were included if they reported adjusted combined odds ratio (COR) and corresponding 95% confidence intervals (CIs) or enough information to quantify the association between risk for AD in late-life and baseline VRFs of midlife. RESULTS: There were positive and significant associations between high blood pressure (COR 1.31; 95% CI: 1.01-1.70), hypercholesterolemia (COR 1.72; 95% CI: 1.32-2.24), obesity (COR 1.88; 95% CI: 1.32-2.69), and diabetes mellitus in midlife (COR 1.4; 95% CI: 1.25-1.57). Smoking and hyperhomocysteinemia (although only one high-quality paper) were also associated with an increased risk of AD generally. CONCLUSIONS: These results strengthen the epidemiological evidence that VRFs of midlife significantly increase risk for AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25024338/full_citation L2 - http://iospress.metapress.com/openurl.asp?genre=article&issn=1387-2877&volume=42&issue=4&spage=1295 ER -