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Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis.
J Alzheimers Dis 2014; 42(4):1295-310JA

Abstract

BACKGROUND/OBJECTIVE

We examine whether midlife vascular risk factors (VRFs) are associated with increased risk of incident Alzheimer's disease (AD) in a systematic review and meta-analysis of published cohort studies.

METHODS

Original cohort studies were included if they reported adjusted combined odds ratio (COR) and corresponding 95% confidence intervals (CIs) or enough information to quantify the association between risk for AD in late-life and baseline VRFs of midlife.

RESULTS

There were positive and significant associations between high blood pressure (COR 1.31; 95% CI: 1.01-1.70), hypercholesterolemia (COR 1.72; 95% CI: 1.32-2.24), obesity (COR 1.88; 95% CI: 1.32-2.69), and diabetes mellitus in midlife (COR 1.4; 95% CI: 1.25-1.57). Smoking and hyperhomocysteinemia (although only one high-quality paper) were also associated with an increased risk of AD generally.

CONCLUSIONS

These results strengthen the epidemiological evidence that VRFs of midlife significantly increase risk for AD.

Authors+Show Affiliations

Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China.Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25024338

Citation

Meng, Xiang-Fei, et al. "Midlife Vascular Risk Factors and the Risk of Alzheimer's Disease: a Systematic Review and Meta-analysis." Journal of Alzheimer's Disease : JAD, vol. 42, no. 4, 2014, pp. 1295-310.
Meng XF, Yu JT, Wang HF, et al. Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;42(4):1295-310.
Meng, X. F., Yu, J. T., Wang, H. F., Tan, M. S., Wang, C., Tan, C. C., & Tan, L. (2014). Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis. Journal of Alzheimer's Disease : JAD, 42(4), pp. 1295-310. doi:10.3233/JAD-140954.
Meng XF, et al. Midlife Vascular Risk Factors and the Risk of Alzheimer's Disease: a Systematic Review and Meta-analysis. J Alzheimers Dis. 2014;42(4):1295-310. PubMed PMID: 25024338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis. AU - Meng,Xiang-Fei, AU - Yu,Jin-Tai, AU - Wang,Hui-Fu, AU - Tan,Meng-Shan, AU - Wang,Chong, AU - Tan,Chen-Chen, AU - Tan,Lan, PY - 2014/7/16/entrez PY - 2014/7/16/pubmed PY - 2015/7/24/medline KW - Alzheimer's disease KW - diabetes mellitus KW - high blood pressure KW - hypercholesterolemia KW - hyperhomocysteinemia KW - meta-analysis KW - midlife vascular risk factors KW - obesity KW - smoking KW - systematic review SP - 1295 EP - 310 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 42 IS - 4 N2 - BACKGROUND/OBJECTIVE: We examine whether midlife vascular risk factors (VRFs) are associated with increased risk of incident Alzheimer's disease (AD) in a systematic review and meta-analysis of published cohort studies. METHODS: Original cohort studies were included if they reported adjusted combined odds ratio (COR) and corresponding 95% confidence intervals (CIs) or enough information to quantify the association between risk for AD in late-life and baseline VRFs of midlife. RESULTS: There were positive and significant associations between high blood pressure (COR 1.31; 95% CI: 1.01-1.70), hypercholesterolemia (COR 1.72; 95% CI: 1.32-2.24), obesity (COR 1.88; 95% CI: 1.32-2.69), and diabetes mellitus in midlife (COR 1.4; 95% CI: 1.25-1.57). Smoking and hyperhomocysteinemia (although only one high-quality paper) were also associated with an increased risk of AD generally. CONCLUSIONS: These results strengthen the epidemiological evidence that VRFs of midlife significantly increase risk for AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25024338/full_citation L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-140954 DB - PRIME DP - Unbound Medicine ER -