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Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease.
J Alzheimers Dis. 2014; 42(4):1397-405.JA

Abstract

Previous in vitro studies have shown that walnut extract can inhibit amyloid-β (Aβ) fibrillization, can solubilize its fibrils, and has a protective effect against Aβ-induced oxidative stress and cellular death. In this study, we analyzed the effect of dietary supplementation with walnuts on learning skills, memory, anxiety, locomotor activity, and motor coordination in the Tg2576 transgenic (tg) mouse model of Alzheimer's disease (AD-tg). From the age of 4 months, the experimental groups of AD-tg mice were fed custom-mixed diets containing 6% walnuts (T6) or 9% walnuts (T9), i.e., equivalent to 1 or 1.5 oz, respectively, of walnuts per day in humans. The control groups, i.e., AD-tg and wild-type mice, were fed a diet without walnuts (T0, Wt). These experimental and control mice were examined at the ages of 13-14 months by Morris water maze (for spatial memory and learning ability), T maze (for position discrimination learning ability), rotarod (for psychomotor coordination), and elevated plus maze (for anxiety-related behavior). AD-tg mice on the control diet (T0) showed memory deficit, anxiety-related behavior, and severe impairment in spatial learning ability, position discrimination learning ability, and motor coordination compared to the Wt mice on the same diet. The AD-tg mice receiving the diets with 6% or 9% walnuts (T6 and T9) showed a significant improvement in memory, learning ability, anxiety, and motor development compared to the AD-tg mice on the control diet (T0). There was no statistically significant difference in behavioral performance between the T6/T9 mice on walnuts-enriched diets and the Wt group on the control diet. These findings suggest that dietary supplementation with walnuts may have a beneficial effect in reducing the risk, delaying the onset, or slowing the progression of, or preventing AD.

Authors+Show Affiliations

NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25024344

Citation

Muthaiyah, Balu, et al. "Dietary Supplementation of Walnuts Improves Memory Deficits and Learning Skills in Transgenic Mouse Model of Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 42, no. 4, 2014, pp. 1397-405.
Muthaiyah B, Essa MM, Lee M, et al. Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2014;42(4):1397-405.
Muthaiyah, B., Essa, M. M., Lee, M., Chauhan, V., Kaur, K., & Chauhan, A. (2014). Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 42(4), 1397-405. https://doi.org/10.3233/JAD-140675
Muthaiyah B, et al. Dietary Supplementation of Walnuts Improves Memory Deficits and Learning Skills in Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2014;42(4):1397-405. PubMed PMID: 25024344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease. AU - Muthaiyah,Balu, AU - Essa,Musthafa M, AU - Lee,Moon, AU - Chauhan,Ved, AU - Kaur,Kulbir, AU - Chauhan,Abha, PY - 2014/7/16/entrez PY - 2014/7/16/pubmed PY - 2015/7/24/medline KW - Alzheimer's disease KW - antioxidants KW - dementia KW - inflammation KW - oxidative stress KW - transgenic mice KW - walnuts SP - 1397 EP - 405 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 42 IS - 4 N2 - Previous in vitro studies have shown that walnut extract can inhibit amyloid-β (Aβ) fibrillization, can solubilize its fibrils, and has a protective effect against Aβ-induced oxidative stress and cellular death. In this study, we analyzed the effect of dietary supplementation with walnuts on learning skills, memory, anxiety, locomotor activity, and motor coordination in the Tg2576 transgenic (tg) mouse model of Alzheimer's disease (AD-tg). From the age of 4 months, the experimental groups of AD-tg mice were fed custom-mixed diets containing 6% walnuts (T6) or 9% walnuts (T9), i.e., equivalent to 1 or 1.5 oz, respectively, of walnuts per day in humans. The control groups, i.e., AD-tg and wild-type mice, were fed a diet without walnuts (T0, Wt). These experimental and control mice were examined at the ages of 13-14 months by Morris water maze (for spatial memory and learning ability), T maze (for position discrimination learning ability), rotarod (for psychomotor coordination), and elevated plus maze (for anxiety-related behavior). AD-tg mice on the control diet (T0) showed memory deficit, anxiety-related behavior, and severe impairment in spatial learning ability, position discrimination learning ability, and motor coordination compared to the Wt mice on the same diet. The AD-tg mice receiving the diets with 6% or 9% walnuts (T6 and T9) showed a significant improvement in memory, learning ability, anxiety, and motor development compared to the AD-tg mice on the control diet (T0). There was no statistically significant difference in behavioral performance between the T6/T9 mice on walnuts-enriched diets and the Wt group on the control diet. These findings suggest that dietary supplementation with walnuts may have a beneficial effect in reducing the risk, delaying the onset, or slowing the progression of, or preventing AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25024344/Dietary_supplementation_of_walnuts_improves_memory_deficits_and_learning_skills_in_transgenic_mouse_model_of_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-140675 DB - PRIME DP - Unbound Medicine ER -