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Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering.
Indian J Anaesth. 2014 May; 58(3):257-62.IJ

Abstract

BACKGROUND AND AIMS

Dexmedetomidine (α2 adrenergic agonist) has been used for prevention of post anaesthesia shivering. Its use for the treatment of post-spinal anaesthesia shivering has not been evaluated. The aim of this study was to evaluate and compare the efficacy, haemodynamic and adverse effects of dexmedetomidine with those of tramadol, when used for control of post-spinal anaesthesia shivering.

METHODS

A prospective, randomised, and double-blind study was conducted in 50 American Society of Anaesthesiologists Grade I and II patients of either gender, aged between 18 and 65 years, scheduled for various surgical procedures under spinal anaesthesia. The patients were randomised in two groups of 25 patients each to receive either dexmedetomidine 0.5 μg/kg or tramadol 0.5 mg/kg as a slow intravenous bolus. Grade of shivering, onset of shivering, time for cessation of shivering, recurrence, response rate, and adverse effects were observed at scheduled intervals. Unpaired t-test was used for analysing the data.

RESULTS

Time taken for cessation of shivering was significantly less with dexmedetomidine when compared to tramadol. Nausea and vomiting was observed only in tramadol group (28% and; 20% respectively). There was not much difference in the sedation profile of both the drugs.

CONCLUSION

We conclude that although both drugs are effective, the time taken for cessation of shivering is less with dexmedetomidine when compared to tramadol. Moreover, dexmedetomidine has negligible adverse effects, whereas tramadol is associated with significant nausea and vomiting.

Authors+Show Affiliations

Department of Anaesthesia, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Department of Anaesthesia, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25024466

Citation

Mittal, Geeta, et al. "Randomised Double-blind Comparative Study of Dexmedetomidine and Tramadol for Post-spinal Anaesthesia Shivering." Indian Journal of Anaesthesia, vol. 58, no. 3, 2014, pp. 257-62.
Mittal G, Gupta K, Katyal S, et al. Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering. Indian journal of anaesthesia. 2014;58(3):257-62.
Mittal, G., Gupta, K., Katyal, S., & Kaushal, S. (2014). Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering. Indian Journal of Anaesthesia, 58(3), 257-62. https://doi.org/10.4103/0019-5049.135031
Mittal G, et al. Randomised Double-blind Comparative Study of Dexmedetomidine and Tramadol for Post-spinal Anaesthesia Shivering. Indian journal of anaesthesia. 2014;58(3):257-62. PubMed PMID: 25024466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering. AU - Mittal,Geeta, AU - Gupta,Kanchan, AU - Katyal,Sunil, AU - Kaushal,Sandeep, PY - 2014/7/16/entrez PY - 2014/7/16/pubmed PY - 2014/7/16/medline KW - Dexmedetomidine KW - post-spinal anaesthesia shivering KW - tramadol SP - 257 EP - 62 JF - Indian journal of anaesthesia VL - 58 IS - 3 N2 - BACKGROUND AND AIMS: Dexmedetomidine (α2 adrenergic agonist) has been used for prevention of post anaesthesia shivering. Its use for the treatment of post-spinal anaesthesia shivering has not been evaluated. The aim of this study was to evaluate and compare the efficacy, haemodynamic and adverse effects of dexmedetomidine with those of tramadol, when used for control of post-spinal anaesthesia shivering. METHODS: A prospective, randomised, and double-blind study was conducted in 50 American Society of Anaesthesiologists Grade I and II patients of either gender, aged between 18 and 65 years, scheduled for various surgical procedures under spinal anaesthesia. The patients were randomised in two groups of 25 patients each to receive either dexmedetomidine 0.5 μg/kg or tramadol 0.5 mg/kg as a slow intravenous bolus. Grade of shivering, onset of shivering, time for cessation of shivering, recurrence, response rate, and adverse effects were observed at scheduled intervals. Unpaired t-test was used for analysing the data. RESULTS: Time taken for cessation of shivering was significantly less with dexmedetomidine when compared to tramadol. Nausea and vomiting was observed only in tramadol group (28% and; 20% respectively). There was not much difference in the sedation profile of both the drugs. CONCLUSION: We conclude that although both drugs are effective, the time taken for cessation of shivering is less with dexmedetomidine when compared to tramadol. Moreover, dexmedetomidine has negligible adverse effects, whereas tramadol is associated with significant nausea and vomiting. SN - 0019-5049 UR - https://www.unboundmedicine.com/medline/citation/25024466/Randomised_double_blind_comparative_study_of_dexmedetomidine_and_tramadol_for_post_spinal_anaesthesia_shivering_ L2 - http://www.ijaweb.org/article.asp?issn=0019-5049;year=2014;volume=58;issue=3;spage=257;epage=262;aulast=Mittal DB - PRIME DP - Unbound Medicine ER -
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