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Selection of appropriate endoscopic therapies for duodenal tumors: an open-label study, single-center experience.
World J Gastroenterol 2014; 20(26):8624-30WJ

Abstract

AIM

To determine an appropriate compartmentalization of endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) for duodenal tumors.

METHODS

Forty-six duodenal lesions (excluding papillary lesions) from 44 patients with duodenal tumors treated endoscopically between 2005 and 2013 were divided into the ESD and EMR groups for retrospective comparison and analysis.

RESULTS

The mean age was 65 ± 9 years (35-79 years). There were 24 lesions from men and 22 from women. The lesions consisted of 6 early cancers, 31 adenomas and 9 neuroendocrine tumors. Lesion location was the duodenal bulb in 15 cases and the descending part of the duodenum in 31 cases. The most common macroscopic morphology was elevated type in 21 cases (45.6%). Mean tumor diameter was 11.9 ± 9.7 mm (3-60 mm). Treatment procedure was ESD (15 cases) vs EMR (31 cases). The examined parameters in the ESD vs EMR groups were as follows: mean tumor diameter, 12.9 ± 14.3 mm (3-60 mm) vs 11.4 ± 6.7 mm (4-25 mm); en bloc resection rate, 86.7% vs 83.9%; complete resection rate, 86.7% vs 74.2%; procedure time, 86.5 ± 63.1 min (15-217 min) vs 13.2 ± 17.0 min (2-89 min) (P < 0.0001); intraprocedural perforation, 3 cases vs none (P = 0.0300); delayed perforation, none in either group; postprocedural bleeding, 1 case vs none; mean postoperative length of hospitalization, 8.2 ± 2.9 d (5-16 d) vs 6.1 ± 2.0 d (2-12 d) (P = 0.0067); recurrence, none vs 1 case (occurring at 7 mo postoperatively).

CONCLUSION

ESD was associated with a longer procedure time and a higher incidence of intraprocedural perforation; EMR was associated with a lower rate of complete resection.

Authors+Show Affiliations

Satohiro Matsumoto, Yukio Yoshida, Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.Satohiro Matsumoto, Yukio Yoshida, Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25024618

Citation

Matsumoto, Satohiro, and Yukio Yoshida. "Selection of Appropriate Endoscopic Therapies for Duodenal Tumors: an Open-label Study, Single-center Experience." World Journal of Gastroenterology, vol. 20, no. 26, 2014, pp. 8624-30.
Matsumoto S, Yoshida Y. Selection of appropriate endoscopic therapies for duodenal tumors: an open-label study, single-center experience. World J Gastroenterol. 2014;20(26):8624-30.
Matsumoto, S., & Yoshida, Y. (2014). Selection of appropriate endoscopic therapies for duodenal tumors: an open-label study, single-center experience. World Journal of Gastroenterology, 20(26), pp. 8624-30. doi:10.3748/wjg.v20.i26.8624.
Matsumoto S, Yoshida Y. Selection of Appropriate Endoscopic Therapies for Duodenal Tumors: an Open-label Study, Single-center Experience. World J Gastroenterol. 2014 Jul 14;20(26):8624-30. PubMed PMID: 25024618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selection of appropriate endoscopic therapies for duodenal tumors: an open-label study, single-center experience. AU - Matsumoto,Satohiro, AU - Yoshida,Yukio, PY - 2014/01/23/received PY - 2014/03/11/revised PY - 2014/04/15/accepted PY - 2014/7/16/entrez PY - 2014/7/16/pubmed PY - 2015/4/14/medline KW - Adenoma KW - Cancer KW - Duodenal tumor KW - Endoscopic mucosal resection KW - Endoscopic submucosal dissection KW - Neuroendocrine tumor SP - 8624 EP - 30 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 26 N2 - AIM: To determine an appropriate compartmentalization of endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) for duodenal tumors. METHODS: Forty-six duodenal lesions (excluding papillary lesions) from 44 patients with duodenal tumors treated endoscopically between 2005 and 2013 were divided into the ESD and EMR groups for retrospective comparison and analysis. RESULTS: The mean age was 65 ± 9 years (35-79 years). There were 24 lesions from men and 22 from women. The lesions consisted of 6 early cancers, 31 adenomas and 9 neuroendocrine tumors. Lesion location was the duodenal bulb in 15 cases and the descending part of the duodenum in 31 cases. The most common macroscopic morphology was elevated type in 21 cases (45.6%). Mean tumor diameter was 11.9 ± 9.7 mm (3-60 mm). Treatment procedure was ESD (15 cases) vs EMR (31 cases). The examined parameters in the ESD vs EMR groups were as follows: mean tumor diameter, 12.9 ± 14.3 mm (3-60 mm) vs 11.4 ± 6.7 mm (4-25 mm); en bloc resection rate, 86.7% vs 83.9%; complete resection rate, 86.7% vs 74.2%; procedure time, 86.5 ± 63.1 min (15-217 min) vs 13.2 ± 17.0 min (2-89 min) (P < 0.0001); intraprocedural perforation, 3 cases vs none (P = 0.0300); delayed perforation, none in either group; postprocedural bleeding, 1 case vs none; mean postoperative length of hospitalization, 8.2 ± 2.9 d (5-16 d) vs 6.1 ± 2.0 d (2-12 d) (P = 0.0067); recurrence, none vs 1 case (occurring at 7 mo postoperatively). CONCLUSION: ESD was associated with a longer procedure time and a higher incidence of intraprocedural perforation; EMR was associated with a lower rate of complete resection. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/25024618/Selection_of_appropriate_endoscopic_therapies_for_duodenal_tumors:_an_open_label_study_single_center_experience_ L2 - http://www.wjgnet.com/1007-9327/full/v20/i26/8624.htm DB - PRIME DP - Unbound Medicine ER -