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In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.
J Agric Food Chem. 2014 Aug 06; 62(31):7771-8.JA

Abstract

This study aimed to explore the potential of polished adlay, brown adlay, adlay bran, and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats. Free and bound phenolic extracts from these materials contained significant amounts of phenolics, with free phenolics dominated by chlorogenic acid and p-coumaric acid while bound phenolics dominated by p-coumaric acid and ferulic acid. Free and bound phenolics of adlay bran exhibited significant xanthine oxidase inhibition activities, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, oxygen radical absorbance capacities, and superoxide radical scavenging activities. Adlay bran phenolics could be effective xanthine oxidase inhibitors and radical scavengers. p-Coumaric acid is a xanthine oxidase inhibitor with strong superoxide radical scavenging activity. However, ferulic acid is a xanthine oxidase inhibitor with weak superoxide radical scavenging activity. Chlorogenic acid is a superoxide radical scavenger with weak xanthine oxidase inhibitory activity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhao M
College of Light Industry and Food Sciences, South China University of Technology , Guangzhou 510640, China.
Zhu D
No affiliation info available
Sun-Waterhouse D
No affiliation info available
Su G
No affiliation info available
Lin L
No affiliation info available
Wang X
No affiliation info available
Dong Y
No affiliation info available

MeSH

AnimalsAntioxidantsChlorogenic AcidCoixCoumaric AcidsEnzyme InhibitorsFree Radical ScavengersHyperuricemiaMaleOxonic AcidPhenolsPlant ExtractsPropionatesRatsRats, Sprague-DawleySeedsUric AcidXanthine Oxidase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25029106

Citation

Zhao, Mouming, et al. "In Vitro and in Vivo Studies On Adlay-derived Seed Extracts: Phenolic Profiles, Antioxidant Activities, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Effects." Journal of Agricultural and Food Chemistry, vol. 62, no. 31, 2014, pp. 7771-8.
Zhao M, Zhu D, Sun-Waterhouse D, et al. In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects. J Agric Food Chem. 2014;62(31):7771-8.
Zhao, M., Zhu, D., Sun-Waterhouse, D., Su, G., Lin, L., Wang, X., & Dong, Y. (2014). In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects. Journal of Agricultural and Food Chemistry, 62(31), 7771-8. https://doi.org/10.1021/jf501952e
Zhao M, et al. In Vitro and in Vivo Studies On Adlay-derived Seed Extracts: Phenolic Profiles, Antioxidant Activities, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Effects. J Agric Food Chem. 2014 Aug 6;62(31):7771-8. PubMed PMID: 25029106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects. AU - Zhao,Mouming, AU - Zhu,Dashuai, AU - Sun-Waterhouse,Dongxiao, AU - Su,Guowan, AU - Lin,Lianzhu, AU - Wang,Xiao, AU - Dong,Yi, Y1 - 2014/07/24/ PY - 2014/7/17/entrez PY - 2014/7/17/pubmed PY - 2015/4/14/medline SP - 7771 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 62 IS - 31 N2 - This study aimed to explore the potential of polished adlay, brown adlay, adlay bran, and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats. Free and bound phenolic extracts from these materials contained significant amounts of phenolics, with free phenolics dominated by chlorogenic acid and p-coumaric acid while bound phenolics dominated by p-coumaric acid and ferulic acid. Free and bound phenolics of adlay bran exhibited significant xanthine oxidase inhibition activities, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, oxygen radical absorbance capacities, and superoxide radical scavenging activities. Adlay bran phenolics could be effective xanthine oxidase inhibitors and radical scavengers. p-Coumaric acid is a xanthine oxidase inhibitor with strong superoxide radical scavenging activity. However, ferulic acid is a xanthine oxidase inhibitor with weak superoxide radical scavenging activity. Chlorogenic acid is a superoxide radical scavenger with weak xanthine oxidase inhibitory activity. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/25029106/In_vitro_and_in_vivo_studies_on_adlay_derived_seed_extracts:_phenolic_profiles_antioxidant_activities_serum_uric_acid_suppression_and_xanthine_oxidase_inhibitory_effects_ DB - PRIME DP - Unbound Medicine ER -