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Stereoisomeric profiling of drugs of abuse and pharmaceuticals in wastewaters of Valencia (Spain).
Sci Total Environ. 2014 Oct 01; 494-495:49-57.ST

Abstract

The enantiomeric and diastereomeric profiling of chiral pharmaceuticals (ephedrine, norephedrine, atenolol and venlafaxine) and illicit drugs (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA) and 3,4-methylenedioxy-N-ethylamphetamine (MDEA)) was undertaken over a period of fourteen consecutive days in three wastewater treatment plants (WWTPs) in the city of Valencia, Spain. Degradation efficiency of WWTPs was found to be compound and enantiomer dependent. Selective enantiomer enrichment was observed for several target analytes. Amphetamine and MDMA were enriched with R(-)-enantiomers. 1S,2S(+)-pseudoephedrine was found to be more readily degradable during activated sludge treatment than its diastereomer 1R,2S(-)-ephedrine. Atenolol underwent enrichment with either S(-)- or R(+)-enantiomer in different WWTPs. This unexpected enantiomeric variation in the stereoselective degradation of atenolol could be attributed to different processes utilized during activated sludge treatment. The application of (enantiomeric) profiling of wastewater revealed usage patterns of chiral drugs in the Valencia region.

Authors+Show Affiliations

Laboratory of Nutrition and Bromatology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés s/n, 46100 Burjassot, Valencia, Spain.University of Bath, Department of Chemistry, Faculty of Science, Bath BA2 7AY, UK. Electronic address: B.Kasprzyk-Hordern@bath.ac.uk.Laboratory of Nutrition and Bromatology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés s/n, 46100 Burjassot, Valencia, Spain.Laboratory of Nutrition and Bromatology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés s/n, 46100 Burjassot, Valencia, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25029504

Citation

Vazquez-Roig, Pablo, et al. "Stereoisomeric Profiling of Drugs of Abuse and Pharmaceuticals in Wastewaters of Valencia (Spain)." The Science of the Total Environment, vol. 494-495, 2014, pp. 49-57.
Vazquez-Roig P, Kasprzyk-Hordern B, Blasco C, et al. Stereoisomeric profiling of drugs of abuse and pharmaceuticals in wastewaters of Valencia (Spain). Sci Total Environ. 2014;494-495:49-57.
Vazquez-Roig, P., Kasprzyk-Hordern, B., Blasco, C., & Picó, Y. (2014). Stereoisomeric profiling of drugs of abuse and pharmaceuticals in wastewaters of Valencia (Spain). The Science of the Total Environment, 494-495, 49-57. https://doi.org/10.1016/j.scitotenv.2014.06.098
Vazquez-Roig P, et al. Stereoisomeric Profiling of Drugs of Abuse and Pharmaceuticals in Wastewaters of Valencia (Spain). Sci Total Environ. 2014 Oct 1;494-495:49-57. PubMed PMID: 25029504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stereoisomeric profiling of drugs of abuse and pharmaceuticals in wastewaters of Valencia (Spain). AU - Vazquez-Roig,Pablo, AU - Kasprzyk-Hordern,Barbara, AU - Blasco,Cristina, AU - Picó,Yolanda, Y1 - 2014/07/12/ PY - 2014/05/31/received PY - 2014/06/21/revised PY - 2014/06/21/accepted PY - 2014/7/17/entrez PY - 2014/7/17/pubmed PY - 2015/5/13/medline KW - Chiral drugs KW - Drugs of abuse KW - Enantiomers KW - Pharmaceuticals KW - Stereoisomers KW - Wastewater SP - 49 EP - 57 JF - The Science of the total environment JO - Sci Total Environ VL - 494-495 N2 - The enantiomeric and diastereomeric profiling of chiral pharmaceuticals (ephedrine, norephedrine, atenolol and venlafaxine) and illicit drugs (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA) and 3,4-methylenedioxy-N-ethylamphetamine (MDEA)) was undertaken over a period of fourteen consecutive days in three wastewater treatment plants (WWTPs) in the city of Valencia, Spain. Degradation efficiency of WWTPs was found to be compound and enantiomer dependent. Selective enantiomer enrichment was observed for several target analytes. Amphetamine and MDMA were enriched with R(-)-enantiomers. 1S,2S(+)-pseudoephedrine was found to be more readily degradable during activated sludge treatment than its diastereomer 1R,2S(-)-ephedrine. Atenolol underwent enrichment with either S(-)- or R(+)-enantiomer in different WWTPs. This unexpected enantiomeric variation in the stereoselective degradation of atenolol could be attributed to different processes utilized during activated sludge treatment. The application of (enantiomeric) profiling of wastewater revealed usage patterns of chiral drugs in the Valencia region. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/25029504/Stereoisomeric_profiling_of_drugs_of_abuse_and_pharmaceuticals_in_wastewaters_of_Valencia__Spain__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(14)00971-1 DB - PRIME DP - Unbound Medicine ER -