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Inhaled dry powder formulations for treating tuberculosis.
Curr Drug Deliv. 2015; 12(1):26-39.CD

Abstract

Tuberculosis is the second leading cause of death from infectious diseases. Although antitubercular drugs have been traditionally administered orally, there is a growing interest in delivering drugs via the pulmonary route using nebulisers or dry powder inhalers. Drugs in dry powder inhalers (DPI) are stable and DPI are user-friendly compared to nebulisation which is time consuming, inconvenient and inefficient and requires special equipment. For tuberculosis treatment, drugs should target alveolar macrophages that harbour microorganisms and/or maintain high drug concentration at the infection site in the lung. Drug particles include micro-particles or nanoparticles. Powders can be engineered by micronisation, crystallisation, spray drying, freeze drying and particle coating approaches. The formulation may contain single or combination drugs. This paper will provide an update on current status of TB, its pathogenesis, current treatment strategies, shortcomings of current oral or parenteral delivery strategies, pulmonary delivery devices, advantages of pulmonary delivery of powder formulations, formulation approaches and pharmacokinetic studies of pulmonary delivery of powders for inhalation.

Authors+Show Affiliations

New Zealand's National School of Pharmacy, University of Otago, Adams Building, 18 Frederick Street, P.O. Box 56, Dunedin 9054, New Zealand. Shyamal.das@otago.ac.nz.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25030114

Citation

Das, Shyamal, et al. "Inhaled Dry Powder Formulations for Treating Tuberculosis." Current Drug Delivery, vol. 12, no. 1, 2015, pp. 26-39.
Das S, Tucker I, Stewart P. Inhaled dry powder formulations for treating tuberculosis. Curr Drug Deliv. 2015;12(1):26-39.
Das, S., Tucker, I., & Stewart, P. (2015). Inhaled dry powder formulations for treating tuberculosis. Current Drug Delivery, 12(1), 26-39.
Das S, Tucker I, Stewart P. Inhaled Dry Powder Formulations for Treating Tuberculosis. Curr Drug Deliv. 2015;12(1):26-39. PubMed PMID: 25030114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhaled dry powder formulations for treating tuberculosis. AU - Das,Shyamal, AU - Tucker,Ian, AU - Stewart,Peter, PY - 2014/05/11/received PY - 2014/06/23/revised PY - 2014/07/11/accepted PY - 2014/7/18/entrez PY - 2014/7/18/pubmed PY - 2016/1/7/medline SP - 26 EP - 39 JF - Current drug delivery JO - Curr Drug Deliv VL - 12 IS - 1 N2 - Tuberculosis is the second leading cause of death from infectious diseases. Although antitubercular drugs have been traditionally administered orally, there is a growing interest in delivering drugs via the pulmonary route using nebulisers or dry powder inhalers. Drugs in dry powder inhalers (DPI) are stable and DPI are user-friendly compared to nebulisation which is time consuming, inconvenient and inefficient and requires special equipment. For tuberculosis treatment, drugs should target alveolar macrophages that harbour microorganisms and/or maintain high drug concentration at the infection site in the lung. Drug particles include micro-particles or nanoparticles. Powders can be engineered by micronisation, crystallisation, spray drying, freeze drying and particle coating approaches. The formulation may contain single or combination drugs. This paper will provide an update on current status of TB, its pathogenesis, current treatment strategies, shortcomings of current oral or parenteral delivery strategies, pulmonary delivery devices, advantages of pulmonary delivery of powder formulations, formulation approaches and pharmacokinetic studies of pulmonary delivery of powders for inhalation. SN - 1875-5704 UR - https://www.unboundmedicine.com/medline/citation/25030114/Inhaled_dry_powder_formulations_for_treating_tuberculosis_ L2 - http://www.eurekaselect.com/123433/article DB - PRIME DP - Unbound Medicine ER -